, Test Bank ixix
to accompany
ix ix
Psychopharmacology, Third Edition ixix ix ix
Meyer ix ix • Quenzer
ix ix
Chapter 1: Principles of Pharmacology ixix ixix ixix ixix
Multiple Choice ixix
1. refer(s) to specific molecular changes that occur when a drug binds to ixix ixix ixix ixix ixix ixix ixix ixix ixix ixix ixix
a particular target site or receptor, while are the resulting widespread alterations
ixix ixix ixix ixix ixix ixix ixix ixix ixix ixix ixix
in function.
ixix ixix
a. Drug action; therapeutic effects
ixix ixix ix ix
b. Side effects; drug effects
ixix ixix ix ix
c. Therapeutic effects; side effects ix ix ix ix ix ix
d. Drug action; drug effects ixix ix ix ix ix
Answer: d ixix
Textbook Reference: Pharmacology: The Science of Drug Action
ixix ixix ixix ixix ix ix ixix ix ix
2. After drug administration has occurred, the amount of drug in the blood
ixix ixix i x i x ix ix ix ix ix ix ixix ixix ixix ix ix ixix
that is free to bind at specific target sites is referred to as
ixix ixix ix ix ixix ixix ixix ixix ixix ixix ixix ixix ixix ixix
a. the therapeutic dose.
ixix ix ix
b. first-pass effects. ix ix
c. bioavailability.
d. ED50.
Answer: c ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ix ix ix ix ixix ix ix
3. The specific molecular changes that occur when a drug binds to a particular
ixix ixix ixix ixix ixix ixix ixix ixix ixix ixix ixix ixix
target site or receptor are referred to as
ixix ixix ixix ixix ixix ixix ixix ixix
a. drug effects. ixix
b. drug action. ixix
c. side effects. ixix
d. placebo effects. ixix
Answer: b ixix
Textbook Reference: Pharmacology: The Science of Drug Action
ixix ixix ixix ixix ixix ixix ix ix
4. Which of the following is not a possible explanation for placebo effects?
ixix ix ix ixix ix ix ixix ixix ix ix ix ix ix ix ix ix ixix
a. Pavlovian conditioning ix ix
b. Genetic variation ixix
c. Drug competition ix ix
d. Expectation of outcome ixix ix ix
Answer: c ixix
Textbook Reference: Pharmacology: The Science of Drug Action
ixix ixix ixix ixix ixix ixix ix ix
Page 1 ofi xi x i xi x
247
i xi x
,5. The administration of oxytocin has been proposed as a treatment for ix ix ix ix ix ix ix ix ix ix ix ix ix ix ixix ix ix
autism.
ix ix
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ix ix ix ix ixix ix ix
6. Which factor does not affect the pharmacokinetics of a drug?
ixix ix ix ixix ixi x ix ix ix ix ixix ix ix ix ix
a. Route of administration
ixix ix ix
b. Lipid solubility ix ix
c. Depot binding ix ix
d. Drug action ixix
Answer: d ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ixix ix ix ixix ix ix
7. First-pass metabolism occurs when drugs are taken
ix ix ixix ixix ix ix ix ix ixix
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ix ix ix ix ix ix ix ix
8. The area postrema is one area in the brain where the
ixix ix ix is not complete. ixix ix ix ix ix ix ix ix ix ix ix ixix ix ix ix ix i xi x
a. cerebrospinal fluid ixix
b. blood–brain barrier ix ix
c. choroid plexus ix ix
d. phospholipid membrane ix ix
Answer: b ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ix ix ix ix ixix ixix
9. First-pass metabolism occurs with orally administered drugs because
ixix ixix ix ix ix ix ixix ix ix ix ix
a. their absorption is slowed by food.
ix ix ixix ix ix ix ix ix ix
b. drugs absorbed into the bloodstream from the stomach go to the
ix ix ixix ix ix ixix ix ix ixix ixix i x ix ixix ix ix
liver on the way to general circulation.
ixix ixix ix ix ixix ixix ixix ixix
c. drugs must first survive the acidic environment of the stomach.
ix ix ixix ixix ix ix ix ix ixix ixix ix ix ix ix
d. salivary enzymes in the mouth begin the process of metabolism.
ixix ix ix ixix ix ix ix ix ix ix ix ix ixix ix ix
Answer: b ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ix ix ix ix ixix ix ix
10. Toxic substances in the blood trigger a vomiting response by activating the
ix ix ixix ix ix ix ix ixix ixix ix ix ix ix ix ix ixix ix i x
a. blood–brain barrier. ixix
b. choroid plexus. ix ix
c. area postrema.
ixix
d. median eminence. ix ix
Page 2 ofi xi x i xi x
247
i xi x
, Answer: c ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ix ix ix ix ixix ix ix
11. Drugs administered _ have the most rapid onset of action.
ix ix ix ix ixix ix ix ix ix ix ix ix ix ix ix
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ix ix ix ix ixix ix ix
12. Ionization of a drug depends on the of the solution and the
ixix ixix ixix ixix ixix ixix ixix ixix ixix ixix of the
ixix
drug.
ixix
a. pH; pKa
ixix
b. pKa; pH ix ix
c. concentration; lipid solubility ixix ixix
d. pH; concentration
ix ix
Answer: a ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ix ix ixix ixix ix ix
13. The absorption of a drug depends on all of the following except
ixix ixix ixix ix ix ix ix ix ix ixix ixix ix ix ixix ix ix
a. lipid solubility.
ix ix
b. ionization.
c. body temperature.
ixix
d. the concentration of the drug.
ix ix ix ix ix ix ix ix
Answer: c ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ix ix ix ix ix ix ix ix
14. Drugs that are should be avoided by women of childbearing age.
ix ix ix ix ixix ix ix ix ix ix ix ixix ix ix ix ix
a. teratogenic
b. able to cross the placental barrier
ix ix ixix ix ix ix ix ix ix
c. psychoactive
d. highly lipid-soluble ixix
Answer: a ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ix ix ix ix ixix ix ix
15. Agents that induce developmental abnormalities in a fetus are known as
ix ix ix ix ix ix ixix ix ix ix ix ix ix ixix ixix ixix
a. psychoactive drugs. ixix
b. illicit drugs. ix ix
c. teratogens.
d. placental drugs. ixix
Answer: c ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ix ix ix ix ixix ix ix
16. Depot binding is said to occur when drugs
ix ix ix ix ix ix ix ix ix ix ix ix ixix
a. bind to their target sites.
ix ix ix ix ix ix ixix
Page 3 ofi xi x i xi x
247
i xi x
to accompany
ix ix
Psychopharmacology, Third Edition ixix ix ix
Meyer ix ix • Quenzer
ix ix
Chapter 1: Principles of Pharmacology ixix ixix ixix ixix
Multiple Choice ixix
1. refer(s) to specific molecular changes that occur when a drug binds to ixix ixix ixix ixix ixix ixix ixix ixix ixix ixix ixix
a particular target site or receptor, while are the resulting widespread alterations
ixix ixix ixix ixix ixix ixix ixix ixix ixix ixix ixix
in function.
ixix ixix
a. Drug action; therapeutic effects
ixix ixix ix ix
b. Side effects; drug effects
ixix ixix ix ix
c. Therapeutic effects; side effects ix ix ix ix ix ix
d. Drug action; drug effects ixix ix ix ix ix
Answer: d ixix
Textbook Reference: Pharmacology: The Science of Drug Action
ixix ixix ixix ixix ix ix ixix ix ix
2. After drug administration has occurred, the amount of drug in the blood
ixix ixix i x i x ix ix ix ix ix ix ixix ixix ixix ix ix ixix
that is free to bind at specific target sites is referred to as
ixix ixix ix ix ixix ixix ixix ixix ixix ixix ixix ixix ixix ixix
a. the therapeutic dose.
ixix ix ix
b. first-pass effects. ix ix
c. bioavailability.
d. ED50.
Answer: c ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ix ix ix ix ixix ix ix
3. The specific molecular changes that occur when a drug binds to a particular
ixix ixix ixix ixix ixix ixix ixix ixix ixix ixix ixix ixix
target site or receptor are referred to as
ixix ixix ixix ixix ixix ixix ixix ixix
a. drug effects. ixix
b. drug action. ixix
c. side effects. ixix
d. placebo effects. ixix
Answer: b ixix
Textbook Reference: Pharmacology: The Science of Drug Action
ixix ixix ixix ixix ixix ixix ix ix
4. Which of the following is not a possible explanation for placebo effects?
ixix ix ix ixix ix ix ixix ixix ix ix ix ix ix ix ix ix ixix
a. Pavlovian conditioning ix ix
b. Genetic variation ixix
c. Drug competition ix ix
d. Expectation of outcome ixix ix ix
Answer: c ixix
Textbook Reference: Pharmacology: The Science of Drug Action
ixix ixix ixix ixix ixix ixix ix ix
Page 1 ofi xi x i xi x
247
i xi x
,5. The administration of oxytocin has been proposed as a treatment for ix ix ix ix ix ix ix ix ix ix ix ix ix ix ixix ix ix
autism.
ix ix
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ix ix ix ix ixix ix ix
6. Which factor does not affect the pharmacokinetics of a drug?
ixix ix ix ixix ixi x ix ix ix ix ixix ix ix ix ix
a. Route of administration
ixix ix ix
b. Lipid solubility ix ix
c. Depot binding ix ix
d. Drug action ixix
Answer: d ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ixix ix ix ixix ix ix
7. First-pass metabolism occurs when drugs are taken
ix ix ixix ixix ix ix ix ix ixix
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ix ix ix ix ix ix ix ix
8. The area postrema is one area in the brain where the
ixix ix ix is not complete. ixix ix ix ix ix ix ix ix ix ix ix ixix ix ix ix ix i xi x
a. cerebrospinal fluid ixix
b. blood–brain barrier ix ix
c. choroid plexus ix ix
d. phospholipid membrane ix ix
Answer: b ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ix ix ix ix ixix ixix
9. First-pass metabolism occurs with orally administered drugs because
ixix ixix ix ix ix ix ixix ix ix ix ix
a. their absorption is slowed by food.
ix ix ixix ix ix ix ix ix ix
b. drugs absorbed into the bloodstream from the stomach go to the
ix ix ixix ix ix ixix ix ix ixix ixix i x ix ixix ix ix
liver on the way to general circulation.
ixix ixix ix ix ixix ixix ixix ixix
c. drugs must first survive the acidic environment of the stomach.
ix ix ixix ixix ix ix ix ix ixix ixix ix ix ix ix
d. salivary enzymes in the mouth begin the process of metabolism.
ixix ix ix ixix ix ix ix ix ix ix ix ix ixix ix ix
Answer: b ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ix ix ix ix ixix ix ix
10. Toxic substances in the blood trigger a vomiting response by activating the
ix ix ixix ix ix ix ix ixix ixix ix ix ix ix ix ix ixix ix i x
a. blood–brain barrier. ixix
b. choroid plexus. ix ix
c. area postrema.
ixix
d. median eminence. ix ix
Page 2 ofi xi x i xi x
247
i xi x
, Answer: c ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ix ix ix ix ixix ix ix
11. Drugs administered _ have the most rapid onset of action.
ix ix ix ix ixix ix ix ix ix ix ix ix ix ix ix
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ix ix ix ix ixix ix ix
12. Ionization of a drug depends on the of the solution and the
ixix ixix ixix ixix ixix ixix ixix ixix ixix ixix of the
ixix
drug.
ixix
a. pH; pKa
ixix
b. pKa; pH ix ix
c. concentration; lipid solubility ixix ixix
d. pH; concentration
ix ix
Answer: a ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ix ix ixix ixix ix ix
13. The absorption of a drug depends on all of the following except
ixix ixix ixix ix ix ix ix ix ix ixix ixix ix ix ixix ix ix
a. lipid solubility.
ix ix
b. ionization.
c. body temperature.
ixix
d. the concentration of the drug.
ix ix ix ix ix ix ix ix
Answer: c ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ix ix ix ix ix ix ix ix
14. Drugs that are should be avoided by women of childbearing age.
ix ix ix ix ixix ix ix ix ix ix ix ixix ix ix ix ix
a. teratogenic
b. able to cross the placental barrier
ix ix ixix ix ix ix ix ix ix
c. psychoactive
d. highly lipid-soluble ixix
Answer: a ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ix ix ix ix ixix ix ix
15. Agents that induce developmental abnormalities in a fetus are known as
ix ix ix ix ix ix ixix ix ix ix ix ix ix ixix ixix ixix
a. psychoactive drugs. ixix
b. illicit drugs. ix ix
c. teratogens.
d. placental drugs. ixix
Answer: c ixix
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
ixix ixix ix ix ix ix ixix ix ix
16. Depot binding is said to occur when drugs
ix ix ix ix ix ix ix ix ix ix ix ix ixix
a. bind to their target sites.
ix ix ix ix ix ix ixix
Page 3 ofi xi x i xi x
247
i xi x
