Test Bank for Cellular and Molecular Immunology 10th Edition by Abbas / All Chapters 1 - 21 / Full Complete 2024

TEST BANKX




Cellular and Molecular Immunology
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Abul Abbas, Andrew Lichtman, and Shiv Pillai
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10th Edition
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,Table of Contents
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Chapter 01 Properties and Overview of Immune Responses
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Chapter 02 Cells and Tissues of the Immune System
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Chapter 03 Leukocyte Circulation and Migration Into Tissues
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Chapter 04 Innate Immunity
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Chapter 05 Antibodies and Antigens
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Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
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Histocompatibility Complex Molecules
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Chapter 07 Immune Receptors and Signal Transduction
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Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
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Chapter 09 Activation of T Lymphocytes
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Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
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Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
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Chapter 12 B Cell Activation and Antibody Production
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Chapter 13 Effector Mechanisms of Humoral Immunity
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Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
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Chapter 15 Immunologic Tolerance and Autoimmunity
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Chapter 16 Immunity to Microbes
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Chapter 17 Transplantation Immunology
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Chapter 18 Tumor Immunology
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Chapter 19 Hypersensitivity Disorders
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Chapter 20 Allergy
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Chapter 21 Primary and Acquired Immunodeficiencies
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,Chapter 01: Properties and Overview of Immune Responses
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Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
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MULTIPLE CHOICE X




1. The principal function of the immune system is:
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a. Defense against cancer X X


b. Repair of injured tissues X X X


c. Defense against microbial infections X X X


d. Prevention of inflammatory diseases X X X


e. Protection against environmental toxins X X X




ANS: C X


The immune system has evolved in the setting of selective pressures imposed by microbial i
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nfections. Although immune responses to cancer may occur, the concept that ―immunosurv
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eillance‖ against cancer is a principal function of the immune system is controversial. Repa
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ir of injured tissues may be a secondary consequence of the immune responses and inflamm
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ation. Although the immune system has regulatory features that are needed to prevent exces
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sive inflammation, prevention of inflammatory diseases is not a primary function. The imm
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une system can protect against microbial toxins, but it generally does not offer protection ag
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ainst toxins of nonbiologic origin.
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2. Which of the following infectious diseases was prevented by the first successful
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vaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C X


In 1798, Edward Jenner reported the first intentional successful vaccination, which was aga
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inst smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980, sm
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allpox was reported to be eradicated worldwide by a vaccination program. Effective vaccin
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es against tetanus toxin, rubella virus, and poliovirus were developed in the 20th century an
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d are widely used. There is no effective vaccine against Mycobacterium tuberculosis.
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3. Which of the following is a unique property of the adaptive immune system?
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a. Highly diverse repertoire of specificities for antigens
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b. Self-nonself discrimination X


c. Recognition of microbial structures by both cell-associated and soluble receptors
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d. Protection against viral infections X X X


e. Responses that have the same kinetics and magnitude on repeated exposure to the
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same microbe X




ANS: A X

, Highly diverse repertoires of specificities for antigens are found only in T and B lymphocyt
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es, which are the central cellular components of the adaptive immune system. Both the inna
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te and the adaptive immune systems use cell-
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associated and soluble receptors to recognize microbes, display some degree of self-
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nonself discrimination, and protect against viruses. On repeated exposure to the same micro
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be, the adaptive immune response becomes more rapid and of greater magnitude; this is the
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manifestation of memory. X X




4. Antibodies and T lymphocytes are the respective mediators of which two types of
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immunity?
a. Innate and adaptive X X


b. Passive and active X X


c. Specific and nonspecific X X


d. Humoral and cell-mediated X X


e. Adult and neonatal X X




ANS: D X


Both B and T lymphocytes are principal components of adaptive immunity. B lymphocytes p
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roduce antibodies, which are the recognition and effector molecules of humoral immune resp
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onses to extracellular pathogens. T cells recognize and promote eradication of intracellular p
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athogens in cell- X X


mediated immunity. Passive and active immunity both can be mediated by either B or T lymp
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hocytes. Specific immunity is another term for adaptive immunity. Both B and T lymphocyte
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s participate in adult adaptive immunity but are still developing in the neonatal period.
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5. The two major functional classes of effector T lymphocytes are:
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a. Helper T lymphocytes and cytotoxic T lymphocytes
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b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
XcyStes X X X


c. Memory T cells and effector T cells X X X X X X


d. Helper cells and antigen-presenting cells X X X X


e. Cytotoxic T lymphocytes and target cells X X X X X




ANS: A X


T cells can be classified into effector subsets that perform different effector functions. Most
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effector T cells are either helper T lymphocytes, which enhance the responses of other imm
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une cells, including phagocytes and B cells, to infections, or cytotoxic T lymphocytes, whic
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h directly kill infected cells. Natural killer cells are not T lymphocytes.
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Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. X X X X X X X X X X X X X X




6. Which of the following cell types is required for all adaptive humoral immune responses?
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a. Natural killer cells X X


b. Dendritic cells X


c. Cytolytic T lymphocytes X X


d. B lymphocytes X


e. Helper T lymphocytes X X




ANS: D X


Humoral immune responses are antibody-
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mediated immune responses, and all antibodies are made by B lymphocytes and no other
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cell type. X