HESI Pathophysiology (Latest Syllabus 2025-2026) Real Exam Questions | Verified Model Answers | Question Bank
HESI
PATHOPHYSIOLOGY
(Latest Syllabus 2025-2026) 1200+ Real
Exam Questions | Verified Model
Answers | Question Bank
100% Guarantee Pass
This Exam contains: HESI
✓ Pathophysiology
✓ 100% Accurate Questions and Answers
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✓ Each Question Includes Correct Answer
Updated for 2025-2026 Exam
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, HESI Pathophysiology (Latest Syllabus 2025-2026) Real Exam Questions | Verified Model Answers | Question Bank
Question 1
Which of the following best describes the pathophysiology of asthma?
a) Excessive mucus production in the airways leading to obstruction
b) Chronic inflammation and bronchoconstriction of the airways
c) Destruction of alveoli and decreased lung elasticity
d) Thickening and scarring of lung tissue leading to reduced compliance
Correct Answer
b) chronic inflammation and bronchoconstriction of the airways
Question 2
A patient with diabetes mellitus is experiencing polyuria, polydipsia, and polyphagia. Which of the
following pathophysiological mechanisms is primarily responsible for these symptoms?
a) Hyperglycemia-induced osmotic diuresis
b) Decreased insulin production by the pancreas
c) Insulin resistance at the cellular level
d) Glycosylation of proteins leading to tissue damage
Correct Answer
a) hyperglycemia-induced osmotic diuresis
Question 3
In a patient with congestive heart failure, which of the following pathophysiological changes is most
likely to occur initially as a compensatory mechanism?
a) Activation of the renin-angiotensin-aldosterone system (RAAS)
b) Sympathetic nervous system stimulation
c) Ventricular hypertrophy
d) Pulmonary vasoconstriction
Correct Answer
b) sympathetic nervous system stimulation
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, HESI Pathophysiology (Latest Syllabus 2025-2026) Real Exam Questions | Verified Model Answers | Question Bank
Question 4
What is the primary pathophysiological mechanism underlying rheumatoid arthritis?
a) Autoimmune destruction of joint cartilage and synovial membrane
b) Degeneration of articular cartilage due to mechanical stress
c) Accumulation of uric acid crystals in the joints
d) Excessive production of synovial fluid leading to joint effusion
Correct Answer
a) autoimmune destruction of joint cartilage and synovial membrane
Question 5
Which of the following pathophysiological changes is characteristic of chronic obstructive
pulmonary disease (COPD)?
a) Destruction of alveoli and loss of lung elasticity
b) Inflammation and scarring of the pleura
c) Increased production of surfactant in the lungs
d) Constriction of bronchioles due to smooth muscle hypertrophy
Correct Answer
a) destruction of alveoli and loss of lung elasticity
Question 6
What is the primary pathophysiological mechanism underlying ischemic stroke?
a) Blockage of cerebral blood vessels by a thrombus or embolus
b) Rupture of cerebral blood vessels leading to hemorrhage
c) Impaired cerebral perfusion due to systemic hypotension
d) Compression of cerebral tissue by a tumor or hematoma
Correct Answer
a) blockage of cerebral blood vessels by a thrombus or embolus
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, HESI Pathophysiology (Latest Syllabus 2025-2026) Real Exam Questions | Verified Model Answers | Question Bank
Question 7
Which of the following pathophysiological mechanisms is responsible for the development of
chronic kidney disease (CKD)?
a) Glomerular hyperfiltration and hypertrophy
b) Immune-mediated destruction of renal tubules
c) Obstruction of urinary flow due to kidney stones
d) Progressive loss of nephrons and renal function over time
Correct Answer
d) progressive loss of nephrons and renal function over time
Question 8
In a patient with type 2 diabetes mellitus, which of the following pathophysiological changes is
primarily responsible for insulin resistance?
a) Decreased secretion of insulin by pancreatic beta cells
b) Impaired glucose uptake by peripheral tissues
c) Hyperglycemia-induced inhibition of insulin receptor signaling
d) Dysregulation of hepatic glucose production
Correct Answer
b) impaired glucose uptake by peripheral tissues
Question 9
Which of the following pathophysiological mechanisms is associated with the development of
peptic ulcer disease?
a) Excessive production of gastric acid by parietal cells
b) Impaired mucosal blood flow leading to ischemia
c) Chronic inflammation and infection with Helicobacter pylori
d) Dysfunction of the lower esophageal sphincter allowing reflux of gastric contents
Correct Answer
c) chronic inflammation and infection with H. pylori
Trusted by thousands of students and professionals worldwide Page 4 of 386
HESI
PATHOPHYSIOLOGY
(Latest Syllabus 2025-2026) 1200+ Real
Exam Questions | Verified Model
Answers | Question Bank
100% Guarantee Pass
This Exam contains: HESI
✓ Pathophysiology
✓ 100% Accurate Questions and Answers
100% Guarantee Pass - Verified by
✓ Experts
✓ Each Question Includes Correct Answer
Updated for 2025-2026 Exam
✓ Requirements
Trusted by thousands of students and professionals worldwide
Trusted by thousands of students and professionals worldwide Page 1 of 386
, HESI Pathophysiology (Latest Syllabus 2025-2026) Real Exam Questions | Verified Model Answers | Question Bank
Question 1
Which of the following best describes the pathophysiology of asthma?
a) Excessive mucus production in the airways leading to obstruction
b) Chronic inflammation and bronchoconstriction of the airways
c) Destruction of alveoli and decreased lung elasticity
d) Thickening and scarring of lung tissue leading to reduced compliance
Correct Answer
b) chronic inflammation and bronchoconstriction of the airways
Question 2
A patient with diabetes mellitus is experiencing polyuria, polydipsia, and polyphagia. Which of the
following pathophysiological mechanisms is primarily responsible for these symptoms?
a) Hyperglycemia-induced osmotic diuresis
b) Decreased insulin production by the pancreas
c) Insulin resistance at the cellular level
d) Glycosylation of proteins leading to tissue damage
Correct Answer
a) hyperglycemia-induced osmotic diuresis
Question 3
In a patient with congestive heart failure, which of the following pathophysiological changes is most
likely to occur initially as a compensatory mechanism?
a) Activation of the renin-angiotensin-aldosterone system (RAAS)
b) Sympathetic nervous system stimulation
c) Ventricular hypertrophy
d) Pulmonary vasoconstriction
Correct Answer
b) sympathetic nervous system stimulation
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, HESI Pathophysiology (Latest Syllabus 2025-2026) Real Exam Questions | Verified Model Answers | Question Bank
Question 4
What is the primary pathophysiological mechanism underlying rheumatoid arthritis?
a) Autoimmune destruction of joint cartilage and synovial membrane
b) Degeneration of articular cartilage due to mechanical stress
c) Accumulation of uric acid crystals in the joints
d) Excessive production of synovial fluid leading to joint effusion
Correct Answer
a) autoimmune destruction of joint cartilage and synovial membrane
Question 5
Which of the following pathophysiological changes is characteristic of chronic obstructive
pulmonary disease (COPD)?
a) Destruction of alveoli and loss of lung elasticity
b) Inflammation and scarring of the pleura
c) Increased production of surfactant in the lungs
d) Constriction of bronchioles due to smooth muscle hypertrophy
Correct Answer
a) destruction of alveoli and loss of lung elasticity
Question 6
What is the primary pathophysiological mechanism underlying ischemic stroke?
a) Blockage of cerebral blood vessels by a thrombus or embolus
b) Rupture of cerebral blood vessels leading to hemorrhage
c) Impaired cerebral perfusion due to systemic hypotension
d) Compression of cerebral tissue by a tumor or hematoma
Correct Answer
a) blockage of cerebral blood vessels by a thrombus or embolus
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, HESI Pathophysiology (Latest Syllabus 2025-2026) Real Exam Questions | Verified Model Answers | Question Bank
Question 7
Which of the following pathophysiological mechanisms is responsible for the development of
chronic kidney disease (CKD)?
a) Glomerular hyperfiltration and hypertrophy
b) Immune-mediated destruction of renal tubules
c) Obstruction of urinary flow due to kidney stones
d) Progressive loss of nephrons and renal function over time
Correct Answer
d) progressive loss of nephrons and renal function over time
Question 8
In a patient with type 2 diabetes mellitus, which of the following pathophysiological changes is
primarily responsible for insulin resistance?
a) Decreased secretion of insulin by pancreatic beta cells
b) Impaired glucose uptake by peripheral tissues
c) Hyperglycemia-induced inhibition of insulin receptor signaling
d) Dysregulation of hepatic glucose production
Correct Answer
b) impaired glucose uptake by peripheral tissues
Question 9
Which of the following pathophysiological mechanisms is associated with the development of
peptic ulcer disease?
a) Excessive production of gastric acid by parietal cells
b) Impaired mucosal blood flow leading to ischemia
c) Chronic inflammation and infection with Helicobacter pylori
d) Dysfunction of the lower esophageal sphincter allowing reflux of gastric contents
Correct Answer
c) chronic inflammation and infection with H. pylori
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