Nephritic Syndromes Exam Solved Correctly To Score A+!!
1. Name 6 Clinical Manifestations
*Hematuria
associated with Nephritic Syndrome
*RBC casts
*Azotemia/oliguria
*Mild to moderate
hyper- tension
*Proteinuria < 3.5g/24
hrs (not as severe as
nephrotic syndrome)
*Edema (not as
severe as nephrotic
syndrome)
2. Glomerular damage in nephritic syndrome is primarily Neutrophil
due to infiltration by what inflammatory cell?
3. Salt retention in nephritic syndrome classically Periorbital Edema
mani- fests with what physical exam finding?
4. What is the cutoff for the amount of Proteinuria of < 3.5
proteinuria seen in nephritic syndrome? g/day (usually < 1
g/day).
5. What is the difference in the relative amount
of pro- teinuria seen in nephritic syndrome vs. Nephritic: Usually mild:
nephrotic syn- drome? <
3.5 g/day
Nephrotic: More severe:
3.5g/day or a
protein/cre- atinine ratio
6. How is the presentation of edema in nephrotic > 3.5 (4+ pro- tein on
syn- drome different from the presentation urine dipstick).
of edema in nephritic syndrome?
Nephritic: Usually
, Nephritic Syndromes Exam Solved Correctly To Score A+!!
mild (e.g. periorbital edema) and is due to salt reten- tion.
Nephrotic: More severe and generalized: (anasar-
, Nephritic Syndromes Exam Solved Correctly To Score A+!!
ca) due to
hypoalbumine- mia
and renal sodium re-
tention.
7. What is the difference in the pathogenesis of nephritic Nephritic:
Neutrophil-me-
syndrome vs. nephrotic syndrome? diated glomerular injury.
Nephrotic: T-cells and
cytokines damage
podocytes and cause
podocytes to lose
their negative
charge
8. Nephritic Syndrome vs Nephrotic
Syndrome
9. Post-Streptococcal Glomerulo-Nephritis (PSGN) *Occurs 2 - 3 weeks af-
ter infection with Group
A Beta Hemolytic
Infection (Strep.
Pyogenes)
*Primary infection may in-
volve the pharynx or
skin
*Diagnosis: Antistrep-
tolysin O (ASO) or
Anti-DNase B titers to
doc- ument recent
infection
*Virulence factor: M Pro-
tein
*Common in Children
, Nephritic Syndromes Exam Solved Correctly To Score A+!!
(self limited, good
prognosis)
*In adults, it often pro-
gresses to RPGN
*Presentation: periorbital
and mild peripheral
ede-
1. Name 6 Clinical Manifestations
*Hematuria
associated with Nephritic Syndrome
*RBC casts
*Azotemia/oliguria
*Mild to moderate
hyper- tension
*Proteinuria < 3.5g/24
hrs (not as severe as
nephrotic syndrome)
*Edema (not as
severe as nephrotic
syndrome)
2. Glomerular damage in nephritic syndrome is primarily Neutrophil
due to infiltration by what inflammatory cell?
3. Salt retention in nephritic syndrome classically Periorbital Edema
mani- fests with what physical exam finding?
4. What is the cutoff for the amount of Proteinuria of < 3.5
proteinuria seen in nephritic syndrome? g/day (usually < 1
g/day).
5. What is the difference in the relative amount
of pro- teinuria seen in nephritic syndrome vs. Nephritic: Usually mild:
nephrotic syn- drome? <
3.5 g/day
Nephrotic: More severe:
3.5g/day or a
protein/cre- atinine ratio
6. How is the presentation of edema in nephrotic > 3.5 (4+ pro- tein on
syn- drome different from the presentation urine dipstick).
of edema in nephritic syndrome?
Nephritic: Usually
, Nephritic Syndromes Exam Solved Correctly To Score A+!!
mild (e.g. periorbital edema) and is due to salt reten- tion.
Nephrotic: More severe and generalized: (anasar-
, Nephritic Syndromes Exam Solved Correctly To Score A+!!
ca) due to
hypoalbumine- mia
and renal sodium re-
tention.
7. What is the difference in the pathogenesis of nephritic Nephritic:
Neutrophil-me-
syndrome vs. nephrotic syndrome? diated glomerular injury.
Nephrotic: T-cells and
cytokines damage
podocytes and cause
podocytes to lose
their negative
charge
8. Nephritic Syndrome vs Nephrotic
Syndrome
9. Post-Streptococcal Glomerulo-Nephritis (PSGN) *Occurs 2 - 3 weeks af-
ter infection with Group
A Beta Hemolytic
Infection (Strep.
Pyogenes)
*Primary infection may in-
volve the pharynx or
skin
*Diagnosis: Antistrep-
tolysin O (ASO) or
Anti-DNase B titers to
doc- ument recent
infection
*Virulence factor: M Pro-
tein
*Common in Children
, Nephritic Syndromes Exam Solved Correctly To Score A+!!
(self limited, good
prognosis)
*In adults, it often pro-
gresses to RPGN
*Presentation: periorbital
and mild peripheral
ede-
