2025-2026
hydrocortisone (Solu-Cortef), prednisone, dexamethasone - Answers Protype(s) of
Glucocorticoids
Makes cortisol available for cellular functioning. Cortisol is needed to make glucose available
for use and promote breakdown proteins and lipids for synthesis of glucose. Need increases
with stress. - Answers MOA for hydrocortisone (Solu-Cortef), prednisone, dexamethasone
Replacement therapy for acute and chronic adrenocortical insufficiency (Addison's disease) -
Answers Appropriate therapeutic use for hydrocortisone (Solu-Cortef), prednisone,
dexamethasone
Given PO- total dose at HS or divided (2/3 in am and 1/3 early afternoon). Taper dose gradually,
use lowest dose. - Answers Route for prednisone
Give IV for emergencies - Answers Route for hydrocortisone (Solu-Cortef), dexamethasone
SE/AE: No contraindications/precautions or drug interactions in low therapeutic doses. If higher
doses for pain/inflammation, more side effects. - Answers Nursing implication of
hydrocortisone (Solu-Cortef), prednisone, dexamethasone
Monitor signs of inappropriate dosing: Hypercortisolism-hyperglycemia, fat redistribution,
osteoporosis - Answers Nursing implication of hydrocortisone (Solu-Cortef), prednisone,
dexamethasone
Monitor signs of inappropriate dosing: Hypocortisolism-fatigue, weakness, wt loss,
hypoglycemia - Answers Nursing implication of hydrocortisone (Solu-Cortef), prednisone,
dexamethasone
Monitor CBC, electrolyte, glucose and glucocorticoid level at baseline and periodically - Answers
Nursing implication of hydrocortisone (Solu-Cortef), prednisone, dexamethasone
Educate to wear medic alert bracelet and carry emergency supply of glucocorticoids - Answers
Nursing implication of hydrocortisone (Solu-Cortef), prednisone, dexamethasone
Give supplemental doses when higher stress-physical/mental. Usually 3x regular dose for 3
days. - Answers Nursing implication of hydrocortisone (Solu-Cortef), prednisone,
dexamethasone
Educate on lifelong therapy - Answers Nursing implication of glucocorticoids (i.e.
hydrocortisone) & Mineralocorticoids (i.e. fludrocortisone)
Wear medic alert band - Answers Nursing implication of glucocorticoids (i.e. hydrocortisone) &
Mineralocorticoids (i.e. fludrocortisone)