HESI PHARMACOLOGY EVOLVE NEWEST 2025/2026 EXAM
COMPLETE 300 QUESTIONS AND CORRECT DETAILED ANSWERS
(GUARANTEED PASS) |ALREADY GRADED A+||BRAND NEW
VERSION!!
HESI PHARMACOLOGY 2025.
A client who has been taking phenazopyridine (Pyridium) for symptoms of urethritis and
cystitis comes to the clinic because her urine is reddish-orange. Which question should
the practical nurse ask to determine if the medication has been effective?
A) How much water have you been drinking each day?
B) Does the urine color stain your toilet bowl or undergarments?
C) Have you had any relief from urinary pain, burning, or urgency?
D) Did your urine appear cloudy or have a foul odor on voiding? - - ANS - -C) Have you
had any relief from urinary pain, burning, or urgency?
Feedback:
Phenazopyridine, an over-the-counter urinary analgesic, acts on the mucosa of the
urinary tract to relieve urinary pain, burning, itching, or urgency (C) associated with
urethritis and cystitis. Although determining if the client is forcing fluids (A),
experiencing staining from Pyridium's side effect (B), or having signs of a urinary
infection (D) are worthwhile assessments, the therapeutic response of Pyridium is
related to urinary discomforts only.
A male client who has been receiving an antineoplastic drug has developed
thrombocytopenia. What instructions should the practical nurse (PN) reinforce?
A) Use suppository form of drugs.
B) Avoid large public gatherings.
C) Rise slowly when standing up.
D) Shave with an electric razor. - - ANS - -D) Shave with an electric razor.
Feedback:
Thrombocytopenia is a common side effect of bone marrow depression caused by
several antineoplastic agents. The client is experiencing a low platelet count and should
use an electric razor (D) to reduce his risk of bleeding. (A, B, and C) are not indicated for
a client who needs to implement thrombocytopenia precautions.
The practical nurse (PN) is caring for a client who has been taking prednisone
(Deltasone) daily for a year. Which adverse effect should the PN document in the client's
record?
A) Photosensitvity.
,B) Weight gain.
C) Loss of hair.
D) Pale skin color. - - ANS - -B) Weight gain.
Feedback:
Long term use of prednisone causes fluid retention and redistribution of fat deposition.
Weight gain (B) and moon face reflect adverse effects of long-term prednisone use and
should be documented. (A, C, and D) do not occur with treatment using prednisone.
A female client with recurring headaches tells the practical nurse (PN) that she has been
taking at least 4 grams of acetaminophen a day. Which laboratory studies should the PN
review for this client?
A) Creatinine clearance.
B) Hepatic enzymes.
C) Coagulation values.
D) Arterial blood gases. - - ANS - -B) Hepatic enzymes.
Feedback:
Liver toxicity can occur when doses of acetaminophen exceed 4 grams a day, resulting in
an elevation in hepatic enzyme values (B). (A, C, and D) do not reveal findings related to
acetaminophen toxicity.
A client receives a prescription for an oral opioid analgesic for post-operative pain.
Which adverse effect should the practical nurse (PN) monitor for with the client?
A) Constipation.
B) Photosensitivity.
C) Decreased heart rate.
D) Frequent urination. - - ANS - -A) Constipation.
Feedback:
Opioid analgesics slow peristalsis, which leads to constipation (A), a common side effect
of opiates. (B, C, and D) are not associated with opioid analgesics.
Which action should the practical nurse implement when administering a buccal
medication?
A) Encourage the client to swallow.
B) Administer water with medication.
C) Ensure the medication is positioned under the tongue.
D) Place the medication between the upper molar teeth and cheek. - - ANS - -D) Place
the medication between the upper molar teeth and cheek.
Feedback:
Buccal medications are placed between the upper molar teeth and the cheek (D) for
absorption by the capillaries of the oral mucosa. The client should be cautioned against
swallowing, not (A). Buccal medications are not administered with water (B). (C)
describes sublingual administration.
,What assessment is most important for the practical nurse (PN) to obtain prior to
initiating medication therapy with phenelzine (Nardil) for a client with depression?
A) Activity level.
B) Mood and affect.
C) Understanding of diet modification.
D) The client's support system. - - ANS - -C) Understanding of diet modification.
Feedback:
To prevent a potentially lethal hypertensive crisis, a tyramine-free diet should be
maintained during antidepressant therapy with Nardil, a monoamine oxidase inhibitor
(MAOI). It is most important to determine if the client understands diet modification (C)
before Nardil is initiated to prevent consumption of foods that interact with Nardil.
Although a client's activity level (A) and mood and affect (B) should be monitored during
antidepressant therapy, it is most important that the client understand diet
modifications. The client's support system (D) and network of family and friends is
important, but the client should understand the responsibility of dietary compliance with
the medication regimen.
The practical nurse (PN) is unable to arouse a client who is receiving meperidine
(Demerol) for postoperative pain. The client is stuporous, has constricted pupils, and a
respiratory rate of 8 breaths/minute. Which PRN prescription should the PN give the
client?
A) Naloxone (Narcan).
B) Promethazine (Phenergan).
C) Metoclopramide (Reglan).
D) Bethanechol (Urecholine). - - ANS - -A) Naloxone (Narcan).
Feedback:
Narcan (A) is an opioid antagonist and should be administered to reverse the effects of a
Demerol, an opioid, overdose. (B, C, and D) are common postoperative PRN prescriptions
but are not indicated for narcotic overdose.
On which therapeutic action should the practical nurse (PN) base an explanation to a
client who is receiving a cardiac glycoside?
A) Decreased cardiac output.
B) Increased renal perfusion.
C) Decreased rate of contraction.
D) Increased blood volume. - - ANS - -C) Decreased rate of contraction.
Feedback:
Cardiac glycosides increase the force of cardiac contraction (inotropy) and decrease the
heart rate (chronotropy) (C) by decreasing the speed of conduction through the heart
(dromotropy). (A, B, and D) are incorrect.
, A client with type 1 diabetes mellitus received an early AM dose of regular insulin per
sliding scale. At 10:00 AM, the practical nurse (PN) should report which signs indicative
of hypoglycemia?
A) Urticaria and rash.
B) Nausea and diarrhea.
C) Irritability and confusion.
D) Fruity, acetone odor to the breath. - - ANS - -C) Irritability and confusion.
Feedback:
Irritability and confusion (C) are early signs of hypoglycemia. (A, B, and D) are not signs
of hypoglycemia.
Which prescription should the practical nurse (PN) administer for a client who is
experiencing an anaphylactic reaction to an antibiotic?
A) Ephedra (ma-huang).
B) Epinephrine (Adrenalin).
C) Phenylephrin (Neo-Synephrine).
D) Fexofenadine with pseudoephedrine (Allegra D). - - ANS - -B) Epinephrine (Adrenalin).
Feedback:
Epinephrine (Adrenalin), a potent sympathomimetic, is the drug of choice for the
treatment of anaphylaxis (B). (A, C, and D) are not used for an acute immunololgical
dysfunction that causes cardiovascular effects.
An older adult client receives a prescription for hydrochlorothiazide (HydroDIURIL), a
thiazide diuretic for the treatment of heart failure. Which side effect(s) should the
practical nurse reinforce with the client? (Select all that apply.)
A) Constipation.
B) Fatigue.
C) Edema.
D) Nausea.
E) Dehydration.
F) Blurred vision. - - ANS - -B) Fatigue.
E) Dehydration.
Feedback:
Hydrochlorothiazide (HydroDIURIL), a thiazide diuretic, reduces blood pressure by
reducing blood volume and reducing arterial resistance. Adverse effects of thiazides
include hypokalemia, fatigue (B), dehydration (E), hyperglycemia, and hyperuricemia.
Although (A, C, D and F) may be associated with aging or other pathology, they are not
side effects commonly associated with HydroDIURIL.
A client who returns from surgery for bowel resection complains of severe pain around
the incision. Which assessment is most important for the practical nurse (PN) to obtain
prior to the administration of morphine sulfate?
COMPLETE 300 QUESTIONS AND CORRECT DETAILED ANSWERS
(GUARANTEED PASS) |ALREADY GRADED A+||BRAND NEW
VERSION!!
HESI PHARMACOLOGY 2025.
A client who has been taking phenazopyridine (Pyridium) for symptoms of urethritis and
cystitis comes to the clinic because her urine is reddish-orange. Which question should
the practical nurse ask to determine if the medication has been effective?
A) How much water have you been drinking each day?
B) Does the urine color stain your toilet bowl or undergarments?
C) Have you had any relief from urinary pain, burning, or urgency?
D) Did your urine appear cloudy or have a foul odor on voiding? - - ANS - -C) Have you
had any relief from urinary pain, burning, or urgency?
Feedback:
Phenazopyridine, an over-the-counter urinary analgesic, acts on the mucosa of the
urinary tract to relieve urinary pain, burning, itching, or urgency (C) associated with
urethritis and cystitis. Although determining if the client is forcing fluids (A),
experiencing staining from Pyridium's side effect (B), or having signs of a urinary
infection (D) are worthwhile assessments, the therapeutic response of Pyridium is
related to urinary discomforts only.
A male client who has been receiving an antineoplastic drug has developed
thrombocytopenia. What instructions should the practical nurse (PN) reinforce?
A) Use suppository form of drugs.
B) Avoid large public gatherings.
C) Rise slowly when standing up.
D) Shave with an electric razor. - - ANS - -D) Shave with an electric razor.
Feedback:
Thrombocytopenia is a common side effect of bone marrow depression caused by
several antineoplastic agents. The client is experiencing a low platelet count and should
use an electric razor (D) to reduce his risk of bleeding. (A, B, and C) are not indicated for
a client who needs to implement thrombocytopenia precautions.
The practical nurse (PN) is caring for a client who has been taking prednisone
(Deltasone) daily for a year. Which adverse effect should the PN document in the client's
record?
A) Photosensitvity.
,B) Weight gain.
C) Loss of hair.
D) Pale skin color. - - ANS - -B) Weight gain.
Feedback:
Long term use of prednisone causes fluid retention and redistribution of fat deposition.
Weight gain (B) and moon face reflect adverse effects of long-term prednisone use and
should be documented. (A, C, and D) do not occur with treatment using prednisone.
A female client with recurring headaches tells the practical nurse (PN) that she has been
taking at least 4 grams of acetaminophen a day. Which laboratory studies should the PN
review for this client?
A) Creatinine clearance.
B) Hepatic enzymes.
C) Coagulation values.
D) Arterial blood gases. - - ANS - -B) Hepatic enzymes.
Feedback:
Liver toxicity can occur when doses of acetaminophen exceed 4 grams a day, resulting in
an elevation in hepatic enzyme values (B). (A, C, and D) do not reveal findings related to
acetaminophen toxicity.
A client receives a prescription for an oral opioid analgesic for post-operative pain.
Which adverse effect should the practical nurse (PN) monitor for with the client?
A) Constipation.
B) Photosensitivity.
C) Decreased heart rate.
D) Frequent urination. - - ANS - -A) Constipation.
Feedback:
Opioid analgesics slow peristalsis, which leads to constipation (A), a common side effect
of opiates. (B, C, and D) are not associated with opioid analgesics.
Which action should the practical nurse implement when administering a buccal
medication?
A) Encourage the client to swallow.
B) Administer water with medication.
C) Ensure the medication is positioned under the tongue.
D) Place the medication between the upper molar teeth and cheek. - - ANS - -D) Place
the medication between the upper molar teeth and cheek.
Feedback:
Buccal medications are placed between the upper molar teeth and the cheek (D) for
absorption by the capillaries of the oral mucosa. The client should be cautioned against
swallowing, not (A). Buccal medications are not administered with water (B). (C)
describes sublingual administration.
,What assessment is most important for the practical nurse (PN) to obtain prior to
initiating medication therapy with phenelzine (Nardil) for a client with depression?
A) Activity level.
B) Mood and affect.
C) Understanding of diet modification.
D) The client's support system. - - ANS - -C) Understanding of diet modification.
Feedback:
To prevent a potentially lethal hypertensive crisis, a tyramine-free diet should be
maintained during antidepressant therapy with Nardil, a monoamine oxidase inhibitor
(MAOI). It is most important to determine if the client understands diet modification (C)
before Nardil is initiated to prevent consumption of foods that interact with Nardil.
Although a client's activity level (A) and mood and affect (B) should be monitored during
antidepressant therapy, it is most important that the client understand diet
modifications. The client's support system (D) and network of family and friends is
important, but the client should understand the responsibility of dietary compliance with
the medication regimen.
The practical nurse (PN) is unable to arouse a client who is receiving meperidine
(Demerol) for postoperative pain. The client is stuporous, has constricted pupils, and a
respiratory rate of 8 breaths/minute. Which PRN prescription should the PN give the
client?
A) Naloxone (Narcan).
B) Promethazine (Phenergan).
C) Metoclopramide (Reglan).
D) Bethanechol (Urecholine). - - ANS - -A) Naloxone (Narcan).
Feedback:
Narcan (A) is an opioid antagonist and should be administered to reverse the effects of a
Demerol, an opioid, overdose. (B, C, and D) are common postoperative PRN prescriptions
but are not indicated for narcotic overdose.
On which therapeutic action should the practical nurse (PN) base an explanation to a
client who is receiving a cardiac glycoside?
A) Decreased cardiac output.
B) Increased renal perfusion.
C) Decreased rate of contraction.
D) Increased blood volume. - - ANS - -C) Decreased rate of contraction.
Feedback:
Cardiac glycosides increase the force of cardiac contraction (inotropy) and decrease the
heart rate (chronotropy) (C) by decreasing the speed of conduction through the heart
(dromotropy). (A, B, and D) are incorrect.
, A client with type 1 diabetes mellitus received an early AM dose of regular insulin per
sliding scale. At 10:00 AM, the practical nurse (PN) should report which signs indicative
of hypoglycemia?
A) Urticaria and rash.
B) Nausea and diarrhea.
C) Irritability and confusion.
D) Fruity, acetone odor to the breath. - - ANS - -C) Irritability and confusion.
Feedback:
Irritability and confusion (C) are early signs of hypoglycemia. (A, B, and D) are not signs
of hypoglycemia.
Which prescription should the practical nurse (PN) administer for a client who is
experiencing an anaphylactic reaction to an antibiotic?
A) Ephedra (ma-huang).
B) Epinephrine (Adrenalin).
C) Phenylephrin (Neo-Synephrine).
D) Fexofenadine with pseudoephedrine (Allegra D). - - ANS - -B) Epinephrine (Adrenalin).
Feedback:
Epinephrine (Adrenalin), a potent sympathomimetic, is the drug of choice for the
treatment of anaphylaxis (B). (A, C, and D) are not used for an acute immunololgical
dysfunction that causes cardiovascular effects.
An older adult client receives a prescription for hydrochlorothiazide (HydroDIURIL), a
thiazide diuretic for the treatment of heart failure. Which side effect(s) should the
practical nurse reinforce with the client? (Select all that apply.)
A) Constipation.
B) Fatigue.
C) Edema.
D) Nausea.
E) Dehydration.
F) Blurred vision. - - ANS - -B) Fatigue.
E) Dehydration.
Feedback:
Hydrochlorothiazide (HydroDIURIL), a thiazide diuretic, reduces blood pressure by
reducing blood volume and reducing arterial resistance. Adverse effects of thiazides
include hypokalemia, fatigue (B), dehydration (E), hyperglycemia, and hyperuricemia.
Although (A, C, D and F) may be associated with aging or other pathology, they are not
side effects commonly associated with HydroDIURIL.
A client who returns from surgery for bowel resection complains of severe pain around
the incision. Which assessment is most important for the practical nurse (PN) to obtain
prior to the administration of morphine sulfate?
