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FUNDAMENTALS OF CHEMO AND IMMUNO 2025-2026
REVIEW QUESTIONS WITH VERIFIED ANSWERS
Terms in this set (17) Q & A
>> Alkylating agents
-answer- Cell cycle nonspecific (exert effects in all phases of the cell cycle); directly damage
DNA to prevent cancer cells from reproducing
>> Cytoxan
(cyclophosphamide)
-answer- Alkylating Agent
Vesicant info: may cause irritation
Admin: IV, PO, Intraperitoneal
Contraindications & precautions: hypersensitivity, severe marrow depression, impaired renal
and hepatic dysfuction
Toxicity & adverse: highly emetogenic, encourage aggressive hydration d/t potential acute
hemorrhagic cystitis
>> Cisplatin
-answer- Alkylating Agent
Vesicant info: vesicant >.5 mg/mL, irritant <.5 mg/mL
Admin: IV, Intraperitoneal
Contraindications & precautions: renal impairment, hearing loss, neuropathy
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Toxicity & adverse: severe emetogenic (acute and delayed), acute renal failure, anaphylactic-
type reaction
>> Carboplatin
-answer- Alkylating Agent
Vesicant info: irritant
Admin: IV
Contraindications & precautions: myelosuppression (renal impairment patients), NV,
hypersensitivity, neuropathy, nephrotoxic
Toxicity & adverse: acute: anaphylactic-like reactions, embolism, stroke, and HF; serious:
hematologic toxicity, thrombocytopenia, leukocyte nadir
>> Oxaliplatin (Eloxatin)
-answer- Alkylating Agent
Vesicant info: irritant with vesicant properties; treat like vesicant
Admin: IV
Contraindications & precautions: hx of allergy to oxali or other platinum compounds, women
of childbearing age avoid pregnancy d/t pregnancy risk cat. D, renal impairment,
breastfeeding patients
Toxic & adverse: severe cold sensitivity, anaphylactic reaction, pulmonary fibrosis,
hepatotoxicity, fatigue, HA
>> Antimetabolites
-answer- Act in the S phase; interfere with DNA synthesis; some with enzymes that needed for
FUNDAMENTALS OF CHEMO AND IMMUNO 2025-2026
REVIEW QUESTIONS WITH VERIFIED ANSWERS
Terms in this set (17) Q & A
>> Alkylating agents
-answer- Cell cycle nonspecific (exert effects in all phases of the cell cycle); directly damage
DNA to prevent cancer cells from reproducing
>> Cytoxan
(cyclophosphamide)
-answer- Alkylating Agent
Vesicant info: may cause irritation
Admin: IV, PO, Intraperitoneal
Contraindications & precautions: hypersensitivity, severe marrow depression, impaired renal
and hepatic dysfuction
Toxicity & adverse: highly emetogenic, encourage aggressive hydration d/t potential acute
hemorrhagic cystitis
>> Cisplatin
-answer- Alkylating Agent
Vesicant info: vesicant >.5 mg/mL, irritant <.5 mg/mL
Admin: IV, Intraperitoneal
Contraindications & precautions: renal impairment, hearing loss, neuropathy
, Page 2 of 6
Toxicity & adverse: severe emetogenic (acute and delayed), acute renal failure, anaphylactic-
type reaction
>> Carboplatin
-answer- Alkylating Agent
Vesicant info: irritant
Admin: IV
Contraindications & precautions: myelosuppression (renal impairment patients), NV,
hypersensitivity, neuropathy, nephrotoxic
Toxicity & adverse: acute: anaphylactic-like reactions, embolism, stroke, and HF; serious:
hematologic toxicity, thrombocytopenia, leukocyte nadir
>> Oxaliplatin (Eloxatin)
-answer- Alkylating Agent
Vesicant info: irritant with vesicant properties; treat like vesicant
Admin: IV
Contraindications & precautions: hx of allergy to oxali or other platinum compounds, women
of childbearing age avoid pregnancy d/t pregnancy risk cat. D, renal impairment,
breastfeeding patients
Toxic & adverse: severe cold sensitivity, anaphylactic reaction, pulmonary fibrosis,
hepatotoxicity, fatigue, HA
>> Antimetabolites
-answer- Act in the S phase; interfere with DNA synthesis; some with enzymes that needed for
