Advanced /
Pharmacology
/ /
test 1 Questions With Correct Answers
/ // // // // //
Beta //lactamase //inhibitors //- //verified //answer(s)-✔✔Clavulanic //acid, //sublactam, //taxobactam
Unasyn //- //verified //answer(s)-✔✔Ampicillin //and //sulbactam
Augmentin //- //verified //answer(s)-✔✔Amoxicillin //clavulanic //acid
Hapten //- //verified //answer(s)-✔✔Drug //+plasma //protein //severe //allergic //reaction
Mechanisms //resistance //to //beta //lactamase //- //verified //answer(s)-
✔✔Inactivation /
/by /
/beta /
/lactamase, /
/mutation /
/trans /
/peptidase //target, //impaired //penetration //of //drug //into //organism, //drug //effluent //pumps
MRSA //- //verified //answer(s)-
✔✔Resistant /
/organisms //produce //PBPs //with //decreased //affinity //for //binding //beta //lactam //antibiotics
Impaired //penetration //of //drug //into //organosm //- //verified //answer(s)-
✔✔Absence //of //porins //or //down //regulation //of //porins //or //porins //smaller
,Drug //efflux //pumps //- //verified //answer(s)-
✔✔Nonspecific, //spit //out //whatever //bacteria //doesn't //need, //major //mechanism //MDR
Prevention //of //resistance //steains //- //verified //answer(s)-
✔✔Testing, /
/choose /
/right //antibiotic, //complete //course //therapy, //don't //use //antibiotic //when //not //indicated
Mutidrug //resistant //organisms //- //verified //answer(s)-
✔✔Organisms //that //are //resistant //to //1 //or //more //class //of //organisms. //Drug //efflux //pumps
Penicillin //- //verified //answer(s)-✔✔Bactericidal
Penicillin //adverse //effects //- //verified //answer(s)-
✔✔GI //distress, //oral/vaginal //candidiasis, //rash, //anaphylaxis
Cephalosporins //- //verified //answer(s)-
✔✔More //stable //against //beta //lactamases, //increased //range //activity
1st //generation //cephalosporin //- //verified //answer(s)-✔✔Cefazolin, //cephalexin
G+, //susceptible //beta //lactamase
2,3 //generations //cephalosporins //- //verified //answer(s)-✔✔Broader //spectrum,
Increase //resistance //beta //lactamase, //increase //half //life, //some //cross //BBB
4,5 //generations //cephalosporins //- //verified //answer(s)-
✔✔Cefepine, /
/excellent /
/resistance //most //beta //lactamase, //excellent //CNS //penetration, //ceftaroline //against //MRSA
,Adverse //reactions //cephalosporins //- //verified //answer(s)-
✔✔Hypersensitivity, /
/fever, //skin //rashes, //nephritis, //granulocytopenia, //hemolytic //anemia, //anorexia
Cefotetan //- //verified //answer(s)-
✔✔Avoid //ETOH! //Disulfiram //like //reaction //with //this //cephalosporins
Treatment //for //C //diff //from //broad //spectrum //cephalosporin //- //verified //answer(s)-
✔✔Vancomycin, //metrondiszole
Example //monobactam //- //verified //answer(s)-✔✔Aztreonam
IV //or //IM
Active //against //G //neg //only
Tolerated //by //PCN //allergic //patiemts
Example //carbapenem //- //verified //answer(s)-✔✔Imipenem, //IV //or //IM //only
Widest /
/spectrum /
/of /
/any /
/beta /
/lactam, /
/must /
/prescribe /
/with /
/cilastin /
/to /
/inhibit /
/first /
/pass /
/elimination /
, /by /
/renal /
/enzyme /
/dehydropeptidase, /
/low //crossreactivity //for //PCNs. //Good //for //meningitis, //peritonitis //in //really //sick //patients
Vancomycin //- //verified //answer(s)-✔✔Cell //wall //inhibitor //but //not //beta //lactam, //glycopeptide
//structure, /
/best /
/treatment /
/for /
/MRSA /
/and /
/G+. //Only //use //Italy //to //treat //antibiotic //induced //colitis, //C. //difficile //and //staph //entericolitis
Must //monitor //peak //and //trough, //poorly //absorbed //po
Vancomyicin //- //verified //answer(s)-✔✔Bacterocidal //for //G //+
Vancomycin //- //verified //answer(s)-
✔✔Poor /
/oral //bioavailability, //90% //GFR //eliminated, //if //renal //impairments //can //have //accumulation.
Vancomycin //Adverse //Effect //- //verified //answer(s)-
✔✔Ototoxicity //if //given //with //aminoglycoside!!
Tissue //irritation //at //injection //site, //chill //and //fever
Red //man //syndrome //- //verified //answer(s)-
✔✔Vancomycin /
/if /
/Tate /
/of //infusion //too //fast. //Histamine //release, //hypotension, //flush, //skin //rash. //Prevent //by //1-
2 //hr //infusion //or //pretreat //with //antihistamine
Pharmacology
/ /
test 1 Questions With Correct Answers
/ // // // // //
Beta //lactamase //inhibitors //- //verified //answer(s)-✔✔Clavulanic //acid, //sublactam, //taxobactam
Unasyn //- //verified //answer(s)-✔✔Ampicillin //and //sulbactam
Augmentin //- //verified //answer(s)-✔✔Amoxicillin //clavulanic //acid
Hapten //- //verified //answer(s)-✔✔Drug //+plasma //protein //severe //allergic //reaction
Mechanisms //resistance //to //beta //lactamase //- //verified //answer(s)-
✔✔Inactivation /
/by /
/beta /
/lactamase, /
/mutation /
/trans /
/peptidase //target, //impaired //penetration //of //drug //into //organism, //drug //effluent //pumps
MRSA //- //verified //answer(s)-
✔✔Resistant /
/organisms //produce //PBPs //with //decreased //affinity //for //binding //beta //lactam //antibiotics
Impaired //penetration //of //drug //into //organosm //- //verified //answer(s)-
✔✔Absence //of //porins //or //down //regulation //of //porins //or //porins //smaller
,Drug //efflux //pumps //- //verified //answer(s)-
✔✔Nonspecific, //spit //out //whatever //bacteria //doesn't //need, //major //mechanism //MDR
Prevention //of //resistance //steains //- //verified //answer(s)-
✔✔Testing, /
/choose /
/right //antibiotic, //complete //course //therapy, //don't //use //antibiotic //when //not //indicated
Mutidrug //resistant //organisms //- //verified //answer(s)-
✔✔Organisms //that //are //resistant //to //1 //or //more //class //of //organisms. //Drug //efflux //pumps
Penicillin //- //verified //answer(s)-✔✔Bactericidal
Penicillin //adverse //effects //- //verified //answer(s)-
✔✔GI //distress, //oral/vaginal //candidiasis, //rash, //anaphylaxis
Cephalosporins //- //verified //answer(s)-
✔✔More //stable //against //beta //lactamases, //increased //range //activity
1st //generation //cephalosporin //- //verified //answer(s)-✔✔Cefazolin, //cephalexin
G+, //susceptible //beta //lactamase
2,3 //generations //cephalosporins //- //verified //answer(s)-✔✔Broader //spectrum,
Increase //resistance //beta //lactamase, //increase //half //life, //some //cross //BBB
4,5 //generations //cephalosporins //- //verified //answer(s)-
✔✔Cefepine, /
/excellent /
/resistance //most //beta //lactamase, //excellent //CNS //penetration, //ceftaroline //against //MRSA
,Adverse //reactions //cephalosporins //- //verified //answer(s)-
✔✔Hypersensitivity, /
/fever, //skin //rashes, //nephritis, //granulocytopenia, //hemolytic //anemia, //anorexia
Cefotetan //- //verified //answer(s)-
✔✔Avoid //ETOH! //Disulfiram //like //reaction //with //this //cephalosporins
Treatment //for //C //diff //from //broad //spectrum //cephalosporin //- //verified //answer(s)-
✔✔Vancomycin, //metrondiszole
Example //monobactam //- //verified //answer(s)-✔✔Aztreonam
IV //or //IM
Active //against //G //neg //only
Tolerated //by //PCN //allergic //patiemts
Example //carbapenem //- //verified //answer(s)-✔✔Imipenem, //IV //or //IM //only
Widest /
/spectrum /
/of /
/any /
/beta /
/lactam, /
/must /
/prescribe /
/with /
/cilastin /
/to /
/inhibit /
/first /
/pass /
/elimination /
, /by /
/renal /
/enzyme /
/dehydropeptidase, /
/low //crossreactivity //for //PCNs. //Good //for //meningitis, //peritonitis //in //really //sick //patients
Vancomycin //- //verified //answer(s)-✔✔Cell //wall //inhibitor //but //not //beta //lactam, //glycopeptide
//structure, /
/best /
/treatment /
/for /
/MRSA /
/and /
/G+. //Only //use //Italy //to //treat //antibiotic //induced //colitis, //C. //difficile //and //staph //entericolitis
Must //monitor //peak //and //trough, //poorly //absorbed //po
Vancomyicin //- //verified //answer(s)-✔✔Bacterocidal //for //G //+
Vancomycin //- //verified //answer(s)-
✔✔Poor /
/oral //bioavailability, //90% //GFR //eliminated, //if //renal //impairments //can //have //accumulation.
Vancomycin //Adverse //Effect //- //verified //answer(s)-
✔✔Ototoxicity //if //given //with //aminoglycoside!!
Tissue //irritation //at //injection //site, //chill //and //fever
Red //man //syndrome //- //verified //answer(s)-
✔✔Vancomycin /
/if /
/Tate /
/of //infusion //too //fast. //Histamine //release, //hypotension, //flush, //skin //rash. //Prevent //by //1-
2 //hr //infusion //or //pretreat //with //antihistamine
