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1. What is the primary indication for intravenous immunoglobulin (IVIG)
therapy?
A. Rheumatoid arthritis
B. Primary immunodeficiency disorders
C. Asthma
D. Gout
Answer: B. Primary immunodeficiency disorders
Explanation: IVIG is most commonly used for treating patients with primary
immunodeficiencies such as CVID or XLA.
2. Which immunoglobulin is most abundant in IVIG preparations?
A. IgM
B. IgA
C. IgE
D. IgG
Answer: D. IgG
Explanation: IVIG products are primarily composed of pooled IgG antibodies.
3. What is a common side effect associated with IVIG infusion?
A. Anemia
B. Headache
C. Constipation
D. Rash
Answer: B. Headache
,Explanation: Headache is one of the most frequently reported side effects of
IVIG.
4. What is the recommended initial infusion rate for most IVIG products?
A. 0.5 mg/kg/min
B. 0.01 mL/kg/min
C. 0.5 mL/kg/hr
D. 0.01 mL/kg/hr
Answer: B. 0.01 mL/kg/min
Explanation: Most IVIG products are started at a low rate to monitor for
adverse reactions.
5. Which route of administration is used in SCIG therapy?
A. Intramuscular
B. Subcutaneous
C. Intrathecal
D. Oral
Answer: B. Subcutaneous
Explanation: SCIG is administered into subcutaneous tissue using small
needles.
6. Which patient population typically uses SCIG instead of IVIG?
A. Pediatric oncology patients
B. Hospitalized patients
C. Outpatients with PID
D. Postoperative cardiac patients
Answer: C. Outpatients with PID
Explanation: SCIG is often chosen for stable PID patients to self-administer at
home.
7. What is a major risk associated with IVIG therapy?
,A. Nephrotoxicity
B. Liver failure
C. Retinal damage
D. Hypoglycemia
Answer: A. Nephrotoxicity
Explanation: Some IVIG preparations can cause renal impairment, especially
in at-risk patients.
8. What type of stabilizer is used in most IVIG products to prevent
aggregation?
A. Glucose
B. Sucrose
C. Sodium chloride
D. Heparin
Answer: B. Sucrose
Explanation: Sucrose is used as a stabilizer in some IVIG products, but it's also
linked to nephrotoxicity.
9. What premedication is commonly recommended before IVIG infusion?
A. Antibiotics
B. Antihistamines and acetaminophen
C. Antivirals
D. Corticosteroids
Answer: B. Antihistamines and acetaminophen
Explanation: These reduce the risk of infusion-related side effects.
10. Which factor most influences the choice between IVIG and SCIG?
A. Age of patient
B. Hospital preference
C. Patient lifestyle and tolerance
D. Product cost
Answer: C. Patient lifestyle and tolerance
Explanation: Route of administration should align with patient preference,
access, and tolerance.
, 11. Which component in IVIG products can cause hypersensitivity
reactions in IgA-deficient patients?
A. IgM
B. Sucrose
C. IgA
D. Albumin
Answer: C. IgA
Explanation: Even trace amounts of IgA can trigger reactions in IgA-deficient
individuals.
12. Which monitoring is essential during IVIG therapy?
A. Serum calcium
B. Renal function (BUN/Cr)
C. Vitamin B12
D. Liver enzymes
Answer: B. Renal function (BUN/Cr)
Explanation: IVIG can affect renal function, especially in elderly and high-risk
patients.
13. The half-life of IVIG is approximately:
A. 2 hours
B. 2 days
C. 21 days
D. 60 days
Answer: C. 21 days
Explanation: IgG has a relatively long half-life, allowing for monthly dosing.
14. What is the mechanism of action of IVIG in autoimmune diseases?
A. Direct bactericidal activity
B. Neutralization of cytokines
C. Modulation of immune response
D. Replenishment of red blood cells
1. What is the primary indication for intravenous immunoglobulin (IVIG)
therapy?
A. Rheumatoid arthritis
B. Primary immunodeficiency disorders
C. Asthma
D. Gout
Answer: B. Primary immunodeficiency disorders
Explanation: IVIG is most commonly used for treating patients with primary
immunodeficiencies such as CVID or XLA.
2. Which immunoglobulin is most abundant in IVIG preparations?
A. IgM
B. IgA
C. IgE
D. IgG
Answer: D. IgG
Explanation: IVIG products are primarily composed of pooled IgG antibodies.
3. What is a common side effect associated with IVIG infusion?
A. Anemia
B. Headache
C. Constipation
D. Rash
Answer: B. Headache
,Explanation: Headache is one of the most frequently reported side effects of
IVIG.
4. What is the recommended initial infusion rate for most IVIG products?
A. 0.5 mg/kg/min
B. 0.01 mL/kg/min
C. 0.5 mL/kg/hr
D. 0.01 mL/kg/hr
Answer: B. 0.01 mL/kg/min
Explanation: Most IVIG products are started at a low rate to monitor for
adverse reactions.
5. Which route of administration is used in SCIG therapy?
A. Intramuscular
B. Subcutaneous
C. Intrathecal
D. Oral
Answer: B. Subcutaneous
Explanation: SCIG is administered into subcutaneous tissue using small
needles.
6. Which patient population typically uses SCIG instead of IVIG?
A. Pediatric oncology patients
B. Hospitalized patients
C. Outpatients with PID
D. Postoperative cardiac patients
Answer: C. Outpatients with PID
Explanation: SCIG is often chosen for stable PID patients to self-administer at
home.
7. What is a major risk associated with IVIG therapy?
,A. Nephrotoxicity
B. Liver failure
C. Retinal damage
D. Hypoglycemia
Answer: A. Nephrotoxicity
Explanation: Some IVIG preparations can cause renal impairment, especially
in at-risk patients.
8. What type of stabilizer is used in most IVIG products to prevent
aggregation?
A. Glucose
B. Sucrose
C. Sodium chloride
D. Heparin
Answer: B. Sucrose
Explanation: Sucrose is used as a stabilizer in some IVIG products, but it's also
linked to nephrotoxicity.
9. What premedication is commonly recommended before IVIG infusion?
A. Antibiotics
B. Antihistamines and acetaminophen
C. Antivirals
D. Corticosteroids
Answer: B. Antihistamines and acetaminophen
Explanation: These reduce the risk of infusion-related side effects.
10. Which factor most influences the choice between IVIG and SCIG?
A. Age of patient
B. Hospital preference
C. Patient lifestyle and tolerance
D. Product cost
Answer: C. Patient lifestyle and tolerance
Explanation: Route of administration should align with patient preference,
access, and tolerance.
, 11. Which component in IVIG products can cause hypersensitivity
reactions in IgA-deficient patients?
A. IgM
B. Sucrose
C. IgA
D. Albumin
Answer: C. IgA
Explanation: Even trace amounts of IgA can trigger reactions in IgA-deficient
individuals.
12. Which monitoring is essential during IVIG therapy?
A. Serum calcium
B. Renal function (BUN/Cr)
C. Vitamin B12
D. Liver enzymes
Answer: B. Renal function (BUN/Cr)
Explanation: IVIG can affect renal function, especially in elderly and high-risk
patients.
13. The half-life of IVIG is approximately:
A. 2 hours
B. 2 days
C. 21 days
D. 60 days
Answer: C. 21 days
Explanation: IgG has a relatively long half-life, allowing for monthly dosing.
14. What is the mechanism of action of IVIG in autoimmune diseases?
A. Direct bactericidal activity
B. Neutralization of cytokines
C. Modulation of immune response
D. Replenishment of red blood cells
