u
TestuBankuUnderstandinguPathophysiologyu6thuEdition
Chapter 01: Cellular Biology
u u u
Huether & McCance: Understanding Pathophysiology, 6th Edition
u u u u u u
MULTIPLEuCHOICES
1. Austudentuisuobservinguaucelluunderutheumicroscope.uItuisuobservedutouhaveusupercoileduDNAu
withuhistones.uWhichuofutheufollowinguwouldualsoubeuobservedubyutheustudent?
a. Ausingleucircularuchromosome
b. Aunucleus
c. Free-floatingunuclearumaterial
d. Nouorganelles
ANS:u B
Theucelludescribeduisuaueukaryoticucell,usouituhasuhistonesuanduausupercoileduDNAuwithinuitsun
ucleus;uthus,utheunucleusushouldubeuobserved.uAusingleucircularuchromosomeucalleduauprokar
yoteucontainsufree-floatingunuclearumaterialubutuhasunouorganelles.
REF:u p.u2
2. Aunurseuisuinstructingutheustaffuaboutucellularufunctions.uWhichucellularufunctionuisutheunurseud
escribinguwhenuanuisolateducelluabsorbsuoxygenuanduusesuitutoutransformunutrientsutouenergy?
a. Metabolicuabsorption
b. Communication
c. Secretion
d. Respiration
ANS:u D
TestuBank Pageu1
, TestuBankuUnderstandinguPathophysiologyu6thuEdition
Theucell’suabilityutouabsorbuoxygenuisureferredutouasurespirationuwhileuitsucommunicationuabilityui
nvolvesumaintenanceuofuausteadyudynamicustate,umetabolicuabsorptionuprovidesunutrition,uanduse
cretionuallowsuforutheusynthesizinguofunewusubstances.
REF:u p.u2
3. AueukaryoticucelluisuundergoinguDNAureplication.uInuwhichuregionuofutheucelluwouldumostuofut
heugeneticuinformationubeucontained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. NucleusuCytoplasm
ANS:u C
Theuregionuofutheucelluthatucontainsugeneticumaterial,uincludinguaulargeuamountuofuribonucleicua
cid,umostuofutheuDNA,uanduDNA-
bindinguproteins,uisutheunucleolus,uwhichuisulocateduwithinutheucell’sunucleus.uMitochondriauisu
associateduwithucellularurespiration,uwhileuribosomesuareuinvolveduwithuproteinumanufacturin
g.uCytoplasmuisuaufluidufillinguthatuisuaucomponentuofutheucell.
REF:u p.u2
4. Whichuofutheufollowingucanuremoveuproteinsuattachedutoutheucell’subilayerubyudissolvingutheul
ayeruitself?
a. Peripheralumembraneuproteins
b. Integralumembraneuproteins
c. Glycoproteins
d. Celluadhesionumolecules
ANS:u B
Proteinsudirectlyuattachedutoutheumembraneubilayerucanubeuremovedubyutheuactionuofuintegralum
embraneuproteinsuthatudissolveutheubilayer.uPeripheralumembraneuproteinsuresideuatutheusurfac
euwhileucelluadhesionumoleculesuareuonutheuoutsideuofutheumembrane.uGlycoproteinumarksucell
suandudoesunotufloat.
REF:u p.u7
5. Whichuofutheufollowingucanubindutouplasmaumembraneureceptors?
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, TestuBankuUnderstandinguPathophysiologyu6thuEdition
a. Oxygen
b. Ribosomes
c. Amphipathiculipids
d. Ligands
ANS:u D
Ligandsuareutheuonlyuspecificumoleculesuthatucanubinduwithureceptorsuonutheucellumembrane.
REF:u p.u9
6. Aunurseuisureviewinguaureportufromuaupatientuwithumetastaticucancer.uWhatualternationuinutheeu
pU
xtracellularumatrixuwouldusuNpoRrtSthIeNdG
iaT
gnBo.
siC
suofM
metastaticucancer?
a. Decreasedufibronectin
b. Increaseducollagen
c. Decreaseduelastin
d. Increaseduglycoproteins
ANS:u A
Onlyuaureduceduamountuofufibronectinuisufounduinusomeutypesuofucancerousucells,uallowingut
hemutoutraveluorumetastasize.
REF:u p.u10
7. Whichuformuofucellucommunicationuisuusedutourelateutouotherucellsuinudirectuphysicalucontact?
a. Cellujunction
b. Gapujunction
c. Desmosome
d. Tightujunction
ANS:u A
Cellujunctionsuholducellsutogetheruandupermitumoleculesutoupassufromucellutoucell.
Gapujunctionsuallowuforucellularucommunicationubetweenucells.uNeitherudesmosomesunorutightuj
unctionsuareuassociateduwithucellularucommunication.
REF:u p.u11
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, TestuBankuUnderstandinguPathophysiologyu6thuEdition
8. Pancreaticubetaucellsusecreteuinsulin,uwhichuinhibitsusecretionuofuglucagonufromuneighboringua
lphaucells.uThisuactionuisuanuexampleuofuwhichuofutheufollowingusignalingutypes?
a. Paracrine
b. Autocrine
c. Neurohormonal
d. Hormonal
ANS:u A
Paracrineusignalinguinvolvesutheureleaseuofulocaluchemicalumediatorsuthatuareuquicklyutakenuup,ud
estroyed,uoruimmobilized,uasuinutheucaseuofuinsulinuandutheuinhibitionuofutheusecretionuofuglucago
n.uNoneuofutheuotheruoptionsuinvolveusignalinguthatuisuassociateduwithuaulocaluchemicalumediatoru
likeuinsulin.
REF:u p.u12
9. Inucellularumetabolism,ueachuenzymeuhasuauhighuaffinityuforua:
a. solute.
b. substrate.
c. receptor.
d. ribosome.
ANS:u B
Eachuenzymeuhasuauhighuaffinityuforuausubstrate,uauspecificusubstanceuconvertedutouauproductuofut
heureaction.uCellularumetabolismuisunotudependentuonuanuattractionubetweenuanuenzymeuanduanyu
ofutheuremaininguoptions.
REF:u p.u16
TestuBank Pageu4
TestuBankuUnderstandinguPathophysiologyu6thuEdition
Chapter 01: Cellular Biology
u u u
Huether & McCance: Understanding Pathophysiology, 6th Edition
u u u u u u
MULTIPLEuCHOICES
1. Austudentuisuobservinguaucelluunderutheumicroscope.uItuisuobservedutouhaveusupercoileduDNAu
withuhistones.uWhichuofutheufollowinguwouldualsoubeuobservedubyutheustudent?
a. Ausingleucircularuchromosome
b. Aunucleus
c. Free-floatingunuclearumaterial
d. Nouorganelles
ANS:u B
Theucelludescribeduisuaueukaryoticucell,usouituhasuhistonesuanduausupercoileduDNAuwithinuitsun
ucleus;uthus,utheunucleusushouldubeuobserved.uAusingleucircularuchromosomeucalleduauprokar
yoteucontainsufree-floatingunuclearumaterialubutuhasunouorganelles.
REF:u p.u2
2. Aunurseuisuinstructingutheustaffuaboutucellularufunctions.uWhichucellularufunctionuisutheunurseud
escribinguwhenuanuisolateducelluabsorbsuoxygenuanduusesuitutoutransformunutrientsutouenergy?
a. Metabolicuabsorption
b. Communication
c. Secretion
d. Respiration
ANS:u D
TestuBank Pageu1
, TestuBankuUnderstandinguPathophysiologyu6thuEdition
Theucell’suabilityutouabsorbuoxygenuisureferredutouasurespirationuwhileuitsucommunicationuabilityui
nvolvesumaintenanceuofuausteadyudynamicustate,umetabolicuabsorptionuprovidesunutrition,uanduse
cretionuallowsuforutheusynthesizinguofunewusubstances.
REF:u p.u2
3. AueukaryoticucelluisuundergoinguDNAureplication.uInuwhichuregionuofutheucelluwouldumostuofut
heugeneticuinformationubeucontained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. NucleusuCytoplasm
ANS:u C
Theuregionuofutheucelluthatucontainsugeneticumaterial,uincludinguaulargeuamountuofuribonucleicua
cid,umostuofutheuDNA,uanduDNA-
bindinguproteins,uisutheunucleolus,uwhichuisulocateduwithinutheucell’sunucleus.uMitochondriauisu
associateduwithucellularurespiration,uwhileuribosomesuareuinvolveduwithuproteinumanufacturin
g.uCytoplasmuisuaufluidufillinguthatuisuaucomponentuofutheucell.
REF:u p.u2
4. Whichuofutheufollowingucanuremoveuproteinsuattachedutoutheucell’subilayerubyudissolvingutheul
ayeruitself?
a. Peripheralumembraneuproteins
b. Integralumembraneuproteins
c. Glycoproteins
d. Celluadhesionumolecules
ANS:u B
Proteinsudirectlyuattachedutoutheumembraneubilayerucanubeuremovedubyutheuactionuofuintegralum
embraneuproteinsuthatudissolveutheubilayer.uPeripheralumembraneuproteinsuresideuatutheusurfac
euwhileucelluadhesionumoleculesuareuonutheuoutsideuofutheumembrane.uGlycoproteinumarksucell
suandudoesunotufloat.
REF:u p.u7
5. Whichuofutheufollowingucanubindutouplasmaumembraneureceptors?
TestuBank Pageu2
, TestuBankuUnderstandinguPathophysiologyu6thuEdition
a. Oxygen
b. Ribosomes
c. Amphipathiculipids
d. Ligands
ANS:u D
Ligandsuareutheuonlyuspecificumoleculesuthatucanubinduwithureceptorsuonutheucellumembrane.
REF:u p.u9
6. Aunurseuisureviewinguaureportufromuaupatientuwithumetastaticucancer.uWhatualternationuinutheeu
pU
xtracellularumatrixuwouldusuNpoRrtSthIeNdG
iaT
gnBo.
siC
suofM
metastaticucancer?
a. Decreasedufibronectin
b. Increaseducollagen
c. Decreaseduelastin
d. Increaseduglycoproteins
ANS:u A
Onlyuaureduceduamountuofufibronectinuisufounduinusomeutypesuofucancerousucells,uallowingut
hemutoutraveluorumetastasize.
REF:u p.u10
7. Whichuformuofucellucommunicationuisuusedutourelateutouotherucellsuinudirectuphysicalucontact?
a. Cellujunction
b. Gapujunction
c. Desmosome
d. Tightujunction
ANS:u A
Cellujunctionsuholducellsutogetheruandupermitumoleculesutoupassufromucellutoucell.
Gapujunctionsuallowuforucellularucommunicationubetweenucells.uNeitherudesmosomesunorutightuj
unctionsuareuassociateduwithucellularucommunication.
REF:u p.u11
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, TestuBankuUnderstandinguPathophysiologyu6thuEdition
8. Pancreaticubetaucellsusecreteuinsulin,uwhichuinhibitsusecretionuofuglucagonufromuneighboringua
lphaucells.uThisuactionuisuanuexampleuofuwhichuofutheufollowingusignalingutypes?
a. Paracrine
b. Autocrine
c. Neurohormonal
d. Hormonal
ANS:u A
Paracrineusignalinguinvolvesutheureleaseuofulocaluchemicalumediatorsuthatuareuquicklyutakenuup,ud
estroyed,uoruimmobilized,uasuinutheucaseuofuinsulinuandutheuinhibitionuofutheusecretionuofuglucago
n.uNoneuofutheuotheruoptionsuinvolveusignalinguthatuisuassociateduwithuaulocaluchemicalumediatoru
likeuinsulin.
REF:u p.u12
9. Inucellularumetabolism,ueachuenzymeuhasuauhighuaffinityuforua:
a. solute.
b. substrate.
c. receptor.
d. ribosome.
ANS:u B
Eachuenzymeuhasuauhighuaffinityuforuausubstrate,uauspecificusubstanceuconvertedutouauproductuofut
heureaction.uCellularumetabolismuisunotudependentuonuanuattractionubetweenuanuenzymeuanduanyu
ofutheuremaininguoptions.
REF:u p.u16
TestuBank Pageu4
