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NU 578 UNIT 1 TEST QUESTIONS AND
ANSWERS 2025
Schedule I - correct answer- Drugs in this schedule have no
accepted medical use in the United States and have a high
abuse potential.
Examples are heroin, marijuana, LSD, peyote, etc.
Schedule II - correct answer- Drugs in this schedule have a
high abuse potential with severe psychic or physical
dependence liability. Included are certain narcotic analgesics,
stimulants, and depressant drugs.
Examples are opium, morphine, codeine, hydromorphone,
methadone, meperidine, oxycodone, anileridine, cocaine,
amphetamine, methamphetamine, phenmetrazine,
methylphenidate, amobarbital, pentobarbital, secobarbital,
methaqualone, and phencyclidine.
Schedule III - correct answer- Drugs in this schedule have an
abuse potential less than those in Schedules I and II and
include compounds containing limited quantities of certain
narcotic analgesic drugs, and other drugs such as barbiturates,
glutethimide, methyprylon, and chlorphentemine.
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Any suppository dosage form containing amobarbital,
secobarbital, or pentobarbital is in this schedule.
Schedule IV - correct answer- Drugs in this schedule have an
abuse potential less than those listed in Schedule III and
include such drugs as barbital, phenobarbital, chloral hydrate,
ethchlorvynol, meprobabmate, chlordizepoxide, diazepam,
oxazepam, chloroazepate, flurazepam, etc.
Schedule V - correct answer- Drugs in this schedule have an
abuse potential less than those listed in Schedule IV and
consist primarily of preparations containing limited quantities of
certain narcotic analgesic drugs used for antitussive and
antidiarrheal purposes.
Absorption - correct answer- Process of drug movement from
its site of administration into the blood
Most common mechanism for drug absorption - correct answer-
passive diffusion
First-pass effect
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(presystemic metabolism) - correct answer- Rapid hepatic
inactivation of certain oral drugs
drug is metabolized (chemically altered) as it passes through
either 1) gut wall, and 2) liver.
Distribution - correct answer- drug movement from the blood to
the interstitial space of tissues and from there into cells
Barriers to distribution - correct answer- - Blood brain barrier
- Placenta
Physiologic Factors Affecting Distribution - correct answer- -
Perfusion
- Binding of drug to plasma protein
- Specialized Distribution Barriers
Albumin - correct answer- Binds acidic drugs
Protein (albumin) binding - correct answer- Prevents bound
drug molecules from leaving the bloodstream
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Prolongs the distribution phase (Increases half-life)
alpha-1 acid glycoprotein - correct answer- Binds basic drugs
Reservoir effect - correct answer-
Blood-Brain Barrier (BBB) - correct answer- no intercellular
pores between brain capillary endothelial membranes due to
the presence of tight junctions between cells
To gain access to the brain from the capillaries, drugs must -
correct answer- 1) diffuse across cells (lipid-soluble,
nonionized form)
or
2) or be actively transported by a carrier
Placental Barrier - correct answer- Transfer of drugs is
relatively slow with the
NU 578 UNIT 1 TEST QUESTIONS AND
ANSWERS 2025
Schedule I - correct answer- Drugs in this schedule have no
accepted medical use in the United States and have a high
abuse potential.
Examples are heroin, marijuana, LSD, peyote, etc.
Schedule II - correct answer- Drugs in this schedule have a
high abuse potential with severe psychic or physical
dependence liability. Included are certain narcotic analgesics,
stimulants, and depressant drugs.
Examples are opium, morphine, codeine, hydromorphone,
methadone, meperidine, oxycodone, anileridine, cocaine,
amphetamine, methamphetamine, phenmetrazine,
methylphenidate, amobarbital, pentobarbital, secobarbital,
methaqualone, and phencyclidine.
Schedule III - correct answer- Drugs in this schedule have an
abuse potential less than those in Schedules I and II and
include compounds containing limited quantities of certain
narcotic analgesic drugs, and other drugs such as barbiturates,
glutethimide, methyprylon, and chlorphentemine.
,2 | Page
Any suppository dosage form containing amobarbital,
secobarbital, or pentobarbital is in this schedule.
Schedule IV - correct answer- Drugs in this schedule have an
abuse potential less than those listed in Schedule III and
include such drugs as barbital, phenobarbital, chloral hydrate,
ethchlorvynol, meprobabmate, chlordizepoxide, diazepam,
oxazepam, chloroazepate, flurazepam, etc.
Schedule V - correct answer- Drugs in this schedule have an
abuse potential less than those listed in Schedule IV and
consist primarily of preparations containing limited quantities of
certain narcotic analgesic drugs used for antitussive and
antidiarrheal purposes.
Absorption - correct answer- Process of drug movement from
its site of administration into the blood
Most common mechanism for drug absorption - correct answer-
passive diffusion
First-pass effect
,3 | Page
(presystemic metabolism) - correct answer- Rapid hepatic
inactivation of certain oral drugs
drug is metabolized (chemically altered) as it passes through
either 1) gut wall, and 2) liver.
Distribution - correct answer- drug movement from the blood to
the interstitial space of tissues and from there into cells
Barriers to distribution - correct answer- - Blood brain barrier
- Placenta
Physiologic Factors Affecting Distribution - correct answer- -
Perfusion
- Binding of drug to plasma protein
- Specialized Distribution Barriers
Albumin - correct answer- Binds acidic drugs
Protein (albumin) binding - correct answer- Prevents bound
drug molecules from leaving the bloodstream
, 4 | Page
Prolongs the distribution phase (Increases half-life)
alpha-1 acid glycoprotein - correct answer- Binds basic drugs
Reservoir effect - correct answer-
Blood-Brain Barrier (BBB) - correct answer- no intercellular
pores between brain capillary endothelial membranes due to
the presence of tight junctions between cells
To gain access to the brain from the capillaries, drugs must -
correct answer- 1) diffuse across cells (lipid-soluble,
nonionized form)
or
2) or be actively transported by a carrier
Placental Barrier - correct answer- Transfer of drugs is
relatively slow with the
