BCH 4053 exam 3 questions with correct
answers
allosteric ||regulation ||by ||covalent ||modification ||- ||CORRECT ||ANSWER✔✔-phosphorylation ||of
||Serine, ||Threonine, ||and ||Tyrosine, ||mediated ||by ||kinases ||and ||phosphatases
glycogen ||phosphorylase ||(GPase) ||- ||CORRECT ||ANSWER✔✔-breaks ||down ||glycogen ||
expressed ||in ||muscle ||
phosphorylated ||at ||Ser ||14
when ||GPase ||is ||phosphorylated ||- ||CORRECT ||ANSWER✔✔-phosphorylase ||a
GPase ||is ||dephosphorylated ||- ||CORRECT ||ANSWER✔✔-phosphorylase ||b
GPase ||structure ||and ||function ||- ||CORRECT ||ANSWER✔✔-dimer ||with ||two ||conformations
||(R/T)
shift ||to ||the ||R ||state ||- ||CORRECT ||ANSWER✔✔-phosphorylation
adding ||complexity ||to ||regulation ||by ||phosphorylation ||- ||CORRECT ||ANSWER✔✔-a ||- ||inhibited
||by ||glucose
b- ||activated ||by ||AMP, ||inhibited ||by ||ATP ||or ||G6P
going ||from ||the ||T ||state ||to ||the ||R ||state
drug ||discovery ||- ||CORRECT ||ANSWER✔✔-starts ||with ||a ||lead ||compound; ||natural ||product ||like
||a ||plant; ||should ||have ||high ||affinity ||for ||target
, lead ||compounds ||- ||CORRECT ||ANSWER✔✔-fine ||tune ||drugs
- ||promote ||tighter ||binding ||
- ||minimize ||side ||effects ||
- ||modifications ||- ||methyl, ||chloryl, ||hydroxyl
bioavailability ||- ||CORRECT ||ANSWER✔✔-how ||much ||drug ||reaches ||target; ||must ||be ||easy ||to
||administer
roles ||of ||hormones ||(3) ||- ||CORRECT ||ANSWER✔✔-maintain ||homeostasis
released ||in ||response ||to ||stimuli ||
regulate ||cyclical ||processes
receptors ||- ||CORRECT ||ANSWER✔✔-generate ||second ||messengers ||or ||activate
||kinase/phosphatase ||which ||activate ||an ||enzyme ||cascade
epinephrine ||and ||norepinephrine ||- ||CORRECT ||ANSWER✔✔-fight ||or ||flight ||response
steroid ||hormones ||- ||CORRECT ||ANSWER✔✔-secreted ||by ||gonads ||and ||adrenal ||glands
glucorticoids ||- ||CORRECT ||ANSWER✔✔-stimulates ||glycogen ||and ||fat ||breakdown
mineralcorticoids ||- ||CORRECT ||ANSWER✔✔-regulate ||excretion ||salt ||and ||water ||by ||kidneys
water ||insoluble ||hormones ||- ||CORRECT ||ANSWER✔✔-transported ||by ||transcortin; ||bound
||intracellularly ||and ||spontaneously ||pass ||through ||membrane
answers
allosteric ||regulation ||by ||covalent ||modification ||- ||CORRECT ||ANSWER✔✔-phosphorylation ||of
||Serine, ||Threonine, ||and ||Tyrosine, ||mediated ||by ||kinases ||and ||phosphatases
glycogen ||phosphorylase ||(GPase) ||- ||CORRECT ||ANSWER✔✔-breaks ||down ||glycogen ||
expressed ||in ||muscle ||
phosphorylated ||at ||Ser ||14
when ||GPase ||is ||phosphorylated ||- ||CORRECT ||ANSWER✔✔-phosphorylase ||a
GPase ||is ||dephosphorylated ||- ||CORRECT ||ANSWER✔✔-phosphorylase ||b
GPase ||structure ||and ||function ||- ||CORRECT ||ANSWER✔✔-dimer ||with ||two ||conformations
||(R/T)
shift ||to ||the ||R ||state ||- ||CORRECT ||ANSWER✔✔-phosphorylation
adding ||complexity ||to ||regulation ||by ||phosphorylation ||- ||CORRECT ||ANSWER✔✔-a ||- ||inhibited
||by ||glucose
b- ||activated ||by ||AMP, ||inhibited ||by ||ATP ||or ||G6P
going ||from ||the ||T ||state ||to ||the ||R ||state
drug ||discovery ||- ||CORRECT ||ANSWER✔✔-starts ||with ||a ||lead ||compound; ||natural ||product ||like
||a ||plant; ||should ||have ||high ||affinity ||for ||target
, lead ||compounds ||- ||CORRECT ||ANSWER✔✔-fine ||tune ||drugs
- ||promote ||tighter ||binding ||
- ||minimize ||side ||effects ||
- ||modifications ||- ||methyl, ||chloryl, ||hydroxyl
bioavailability ||- ||CORRECT ||ANSWER✔✔-how ||much ||drug ||reaches ||target; ||must ||be ||easy ||to
||administer
roles ||of ||hormones ||(3) ||- ||CORRECT ||ANSWER✔✔-maintain ||homeostasis
released ||in ||response ||to ||stimuli ||
regulate ||cyclical ||processes
receptors ||- ||CORRECT ||ANSWER✔✔-generate ||second ||messengers ||or ||activate
||kinase/phosphatase ||which ||activate ||an ||enzyme ||cascade
epinephrine ||and ||norepinephrine ||- ||CORRECT ||ANSWER✔✔-fight ||or ||flight ||response
steroid ||hormones ||- ||CORRECT ||ANSWER✔✔-secreted ||by ||gonads ||and ||adrenal ||glands
glucorticoids ||- ||CORRECT ||ANSWER✔✔-stimulates ||glycogen ||and ||fat ||breakdown
mineralcorticoids ||- ||CORRECT ||ANSWER✔✔-regulate ||excretion ||salt ||and ||water ||by ||kidneys
water ||insoluble ||hormones ||- ||CORRECT ||ANSWER✔✔-transported ||by ||transcortin; ||bound
||intracellularly ||and ||spontaneously ||pass ||through ||membrane
