PHM 520 Final Exam Practice || All Answers are Valid.
what type of reactions are the most common cause of drug incompatibility and why? correct
answers acid-base reactions because precipitation of nonionized drug forms
approximately how many commonly used drugs are incompatible or unstable when added or
combined with usual fluids or agents?
a. 10%
b. 30%
c. 50%
d. 70% correct answers b. 30%
an undesirable reaction occurring between a drug and a container, solution, or another drug is
called? correct answers incompatibility
alteration of drug effect due to the influence of another substance is called? correct answers drug
interactions
where do interactions occur? correct answers inside the body
where does incompatibility occur? correct answers in a fluid contianer or infusion line
are interactions or are incompatibilities visible? correct answers incompatibilities
what type of incompatibility results from the modification of pharmacological effect from prior
concomitant administration of other drugs? correct answers therapeutic incompatibilty
,what mechanism of therapeutic incompatibility involves the effect of a drug on another from the
point of view of absorption, distribution, metabolism, and excretion? correct answers
pharmacokinetic
what mechanism of therapeutic incompatibility is related to pharmacological activity of the
interacting drugs such as synergism/antagonism? correct answers pharmacodynamic
pharmacodynamic is what the _______ does to the _______ correct answers drug, body
pharmacokinetic is what the _______ does to the ________ correct answers body, drug
an interaction that results in change in color, odor, taste, viscosity, and morphology is what type
of incompatibility? correct answers physical incompatibility
physical incompatibilities usually refer to? correct answers precipitation or phase separation
what are factors responsible for physical incompatibility? correct answers pH value and buffer
capacity, solubility and precipitation, complex formation, adsorption
what effect will ingestion of antacids over a period of 24 hours have on urinary pH? correct
answers increase pH
are acidic drugs excreted faster or slower when urinary pH is alkaline? correct answers faster
acidic drugs will diffuse back into the blood from the urine when the urine is acidic or alkaline?
correct answers acidic
interactions between ionized drugs will form _______ with _______ charges correct answers
complexes, reduced
,cation-anion interactions result in? correct answers formation of relatively insoluble precipitate
ion pair formation results in? correct answers burying of charges
what is the interaction between a metal atom or ion and another species called? correct answers
chelation
the attachment of a molecule to a surface is called? correct answers adsorption
what type of incompatibility results in change in chemical properties of pharmaceutical dosage
form? correct answers chemical incompatibility
hydrolysis, oxidation, reduction, racemization are types of what incompatibility? correct answers
chemical
which types of solubilization methods use a means of entrapment?
a) complexation
b) micellar
c) hydrotrophy
d) a and b
e) all of the above correct answers *d) a and b
which of the following expresses the number of moles of solute in 1 kg of solvent?
a) molarity (M)
b) molality (m)
c) normality (N)
, d) mole fraction correct answers *b) molality (m)
a is incorrect because molarity expresses the number of moles of solute in 1 liter of SOLUTION
c is wrong because it expresses the number of equivalents of solute in 1 liter of solution
d is wrong because it expresses the ratio of moles of constituent to total moles
driving force in drug movement in aqueous diffusion model:
a) active transport
b) facilitated transport
c) concentration gradient
d) all of the above correct answers *c) concentration gradient
which are most likely to diffuse across membranes:
a) charged drugs
b) ionized drugs
c) polar drugs
d) non-ionized drugs correct answers *d) non-ionized drugs
a, b, and c are all hydrophilic and are not as likely to cross the membrane since membrane
permeability favors more lipophilic drugs
which equation describes change in concentration with time at a specific location by taking into
account the cross sectional area and partition coefficient?
what type of reactions are the most common cause of drug incompatibility and why? correct
answers acid-base reactions because precipitation of nonionized drug forms
approximately how many commonly used drugs are incompatible or unstable when added or
combined with usual fluids or agents?
a. 10%
b. 30%
c. 50%
d. 70% correct answers b. 30%
an undesirable reaction occurring between a drug and a container, solution, or another drug is
called? correct answers incompatibility
alteration of drug effect due to the influence of another substance is called? correct answers drug
interactions
where do interactions occur? correct answers inside the body
where does incompatibility occur? correct answers in a fluid contianer or infusion line
are interactions or are incompatibilities visible? correct answers incompatibilities
what type of incompatibility results from the modification of pharmacological effect from prior
concomitant administration of other drugs? correct answers therapeutic incompatibilty
,what mechanism of therapeutic incompatibility involves the effect of a drug on another from the
point of view of absorption, distribution, metabolism, and excretion? correct answers
pharmacokinetic
what mechanism of therapeutic incompatibility is related to pharmacological activity of the
interacting drugs such as synergism/antagonism? correct answers pharmacodynamic
pharmacodynamic is what the _______ does to the _______ correct answers drug, body
pharmacokinetic is what the _______ does to the ________ correct answers body, drug
an interaction that results in change in color, odor, taste, viscosity, and morphology is what type
of incompatibility? correct answers physical incompatibility
physical incompatibilities usually refer to? correct answers precipitation or phase separation
what are factors responsible for physical incompatibility? correct answers pH value and buffer
capacity, solubility and precipitation, complex formation, adsorption
what effect will ingestion of antacids over a period of 24 hours have on urinary pH? correct
answers increase pH
are acidic drugs excreted faster or slower when urinary pH is alkaline? correct answers faster
acidic drugs will diffuse back into the blood from the urine when the urine is acidic or alkaline?
correct answers acidic
interactions between ionized drugs will form _______ with _______ charges correct answers
complexes, reduced
,cation-anion interactions result in? correct answers formation of relatively insoluble precipitate
ion pair formation results in? correct answers burying of charges
what is the interaction between a metal atom or ion and another species called? correct answers
chelation
the attachment of a molecule to a surface is called? correct answers adsorption
what type of incompatibility results in change in chemical properties of pharmaceutical dosage
form? correct answers chemical incompatibility
hydrolysis, oxidation, reduction, racemization are types of what incompatibility? correct answers
chemical
which types of solubilization methods use a means of entrapment?
a) complexation
b) micellar
c) hydrotrophy
d) a and b
e) all of the above correct answers *d) a and b
which of the following expresses the number of moles of solute in 1 kg of solvent?
a) molarity (M)
b) molality (m)
c) normality (N)
, d) mole fraction correct answers *b) molality (m)
a is incorrect because molarity expresses the number of moles of solute in 1 liter of SOLUTION
c is wrong because it expresses the number of equivalents of solute in 1 liter of solution
d is wrong because it expresses the ratio of moles of constituent to total moles
driving force in drug movement in aqueous diffusion model:
a) active transport
b) facilitated transport
c) concentration gradient
d) all of the above correct answers *c) concentration gradient
which are most likely to diffuse across membranes:
a) charged drugs
b) ionized drugs
c) polar drugs
d) non-ionized drugs correct answers *d) non-ionized drugs
a, b, and c are all hydrophilic and are not as likely to cross the membrane since membrane
permeability favors more lipophilic drugs
which equation describes change in concentration with time at a specific location by taking into
account the cross sectional area and partition coefficient?
