ONS Chemotherapy Immunotherapy Certificate Test Questions with
Answers Graded A
3 major phases of cell division: -
ANSWER -Interphase
Mitotic phase 3 main goals of treatment: - ANSWER -
Cytokinesis Cure
Control
Palliation
3 steps of interphase: - ANSWER -First
growth phase (G1)
Synthesis phase (S phase) Define neoadjuvant therapy - ANSWER -
Second growth phase (G2) Treatment is given prior to surgery to shrink the
tumor
4 phases of mitosis: - ANSWER -Prophase
Metaphase Define adjuvant therapy - ANSWER -
Anaphase Additional cancer treatment given after the
Telophase primary treatment to lower the risk that the
cancer reoccur
Innate immunity: - ANSWER -Non-specific
response, either: Define conditioning/preparative therapy -
1. Barrier (skin, mucous membranes, flora of ANSWER -Treatments used to prepare a
skin/gut) patient for stem cell transplantation
2. Cellular components (phagocytes, natural
killer cells, granulocytes, macrophages)
2 types of conditioning therapies: -
ANSWER -Myeloablative
Adaptive immunity: - ANSWER -Follows Nonmyeloablative
innate immunity if unsuccessful. Memory
immunity, including:
1. Humoral immunity (production of antibodies or
immunoglobulins) Define dose density - ANSWER -Drug dose
2. Cell mediated immunity (dependent upon T per unit of time
cells)
3. Regulatory T -cells (prevent autoimmune
reactions and limit inflammatory responses)
Define dose intensity - ANSWER -Amount
of drug delivered over time
Define mutations - ANSWER -Variations in
the nucleotide sequence of a gene
, ONS Chemotherapy Immunotherapy Certificate Test Questions with
Answers Graded A
How is relative dose intensity (RDI) calculated? - tumors
ANSWER -By comparing the dose that the
patient ACTUALLY received to the planned dose
of the standard regimen
Common nitrosoureas agents: - ANSWER -
Carmustine (BiCNU)
Lomustine (CeeNu)
How do alkylating agents work? - Streptozocin (Zanosar)
ANSWER -By causing a break in the DNA
helix strand, interfering with DNA replication and
causing cell death
Hypersensitivity can occur with late doses of: -
ANSWER -Carboplatin
3 subcategories of alkylating agents: -
ANSWER -1. Nitrogen mustards
2. Platinum-based agents (do not possess an These agents are typically categorized as highly
alkyl group but still termed alkylating agents as emetogenic: - ANSWER -1. Alkylating
they work similarly) agents
3. Nitrosoureas 2. Nitrosoureas
Most common subcategory of alkylating agents: - Pre-administration labs for alkylating agents and
ANSWER -Nitrogen mustards nitrosoureas: - ANSWER -BUN
Creatinine
CBC w/ diff
Common alkylating agents: - ANSWER -
Cyclophosphamide (Cytoxan)
Ifosfamide (Ifex) What is the medication Mesna used for? -
Bendamustine (Treanda) ANSWER -Bladder protectant with
administration of cyclophosphamide or ifosfamide
Common platinum-based agents: -
ANSWER -Cisplatin (Platinol) Instruct pts receiving ________ to avoid
Carboplatin (Paraplatin) exposure to cold air and consuming cold fluids for
3-4 days following treatment - ANSWER -
Oxaliplatin
What is unique about nitrosoureas agents? -
ANSWER -Able to cross the blood-brain
barrier; can be effective in treating some brain How do antimetabolites function? -
Answers Graded A
3 major phases of cell division: -
ANSWER -Interphase
Mitotic phase 3 main goals of treatment: - ANSWER -
Cytokinesis Cure
Control
Palliation
3 steps of interphase: - ANSWER -First
growth phase (G1)
Synthesis phase (S phase) Define neoadjuvant therapy - ANSWER -
Second growth phase (G2) Treatment is given prior to surgery to shrink the
tumor
4 phases of mitosis: - ANSWER -Prophase
Metaphase Define adjuvant therapy - ANSWER -
Anaphase Additional cancer treatment given after the
Telophase primary treatment to lower the risk that the
cancer reoccur
Innate immunity: - ANSWER -Non-specific
response, either: Define conditioning/preparative therapy -
1. Barrier (skin, mucous membranes, flora of ANSWER -Treatments used to prepare a
skin/gut) patient for stem cell transplantation
2. Cellular components (phagocytes, natural
killer cells, granulocytes, macrophages)
2 types of conditioning therapies: -
ANSWER -Myeloablative
Adaptive immunity: - ANSWER -Follows Nonmyeloablative
innate immunity if unsuccessful. Memory
immunity, including:
1. Humoral immunity (production of antibodies or
immunoglobulins) Define dose density - ANSWER -Drug dose
2. Cell mediated immunity (dependent upon T per unit of time
cells)
3. Regulatory T -cells (prevent autoimmune
reactions and limit inflammatory responses)
Define dose intensity - ANSWER -Amount
of drug delivered over time
Define mutations - ANSWER -Variations in
the nucleotide sequence of a gene
, ONS Chemotherapy Immunotherapy Certificate Test Questions with
Answers Graded A
How is relative dose intensity (RDI) calculated? - tumors
ANSWER -By comparing the dose that the
patient ACTUALLY received to the planned dose
of the standard regimen
Common nitrosoureas agents: - ANSWER -
Carmustine (BiCNU)
Lomustine (CeeNu)
How do alkylating agents work? - Streptozocin (Zanosar)
ANSWER -By causing a break in the DNA
helix strand, interfering with DNA replication and
causing cell death
Hypersensitivity can occur with late doses of: -
ANSWER -Carboplatin
3 subcategories of alkylating agents: -
ANSWER -1. Nitrogen mustards
2. Platinum-based agents (do not possess an These agents are typically categorized as highly
alkyl group but still termed alkylating agents as emetogenic: - ANSWER -1. Alkylating
they work similarly) agents
3. Nitrosoureas 2. Nitrosoureas
Most common subcategory of alkylating agents: - Pre-administration labs for alkylating agents and
ANSWER -Nitrogen mustards nitrosoureas: - ANSWER -BUN
Creatinine
CBC w/ diff
Common alkylating agents: - ANSWER -
Cyclophosphamide (Cytoxan)
Ifosfamide (Ifex) What is the medication Mesna used for? -
Bendamustine (Treanda) ANSWER -Bladder protectant with
administration of cyclophosphamide or ifosfamide
Common platinum-based agents: -
ANSWER -Cisplatin (Platinol) Instruct pts receiving ________ to avoid
Carboplatin (Paraplatin) exposure to cold air and consuming cold fluids for
3-4 days following treatment - ANSWER -
Oxaliplatin
What is unique about nitrosoureas agents? -
ANSWER -Able to cross the blood-brain
barrier; can be effective in treating some brain How do antimetabolites function? -
