Lecture 7-GIP and GLP-1 Exam Questions and Answers Solved Correctly Rated A+
glucose-dependent insulinotropic peptide - AnswersGIP
Oral - Answers___ glucose gives greater insulin response than IV, IP, or SC
reduced - AnswersThere is a ____ incretin effect in people with Type 2 Diabetes
Food - Answers___ stimulates incretin secretion
7-36 - AnswersThe bioactive form of GLP-1 is (___) amide
1-42 - AnswersThe bioactive form of GIP is (___)
GLP-1
GIP - AnswersDPP-4 converts ___ and ___ to their inactive metabolites
N - AnswersDPP-4 cleaves off at the ___-terminus of each (GLP-1 and GIP), inactivating them
2 - AnswersDPP-4 cleaves off the first ___ amino acids of GIP and GLP-1, deactivating them
portal
systemic - AnswersDPP-4 is widely expressed, including on the surface of ___ endothelial cells so a large
proportion o GLP-1 and GIP never reach the ___ circulation
9-36
3-42 - AnswersThe inactive form of GLP-1 is (___) amide and the inactive form of GIP is (____)
GIP - AnswersK cells release ___
duodenum - AnswersK cells are primarily found in the ___
GLP-1 - AnswersL cells release ___
ileum and colon - AnswersL cells are found distally, in the ___ and ___
peripheral - AnswersGIP actions occur in ___ tissues
GIP and GLP-1 - AnswersThe incretin effect is lost after ___ and ___ are proteolyzed by DPP-4
nutrients - AnswersGIP secretion is stimulated by ___
depolarization
GIP - AnswersWhen K cells sense nutrients, they promote ___ of the membrane, causing an increase of
Ca2+ into the cell to release ___
, directly - AnswersThe Uptake pathway ___ takes up glucose and ions
2 and 5 - AnswersThe Uptake pathway of glucose via the electroneutral pathway into K cells occurs
through the GLUT___ and GLUT___ transporters
1 and 3 - AnswersThe Uptake pathway of glucose via the electrogenic pathway into K cells occurs
through SGLT___ and SGLT___
- Answers___ of glucose into the K cell occurs via the transporters GLUT2 and GLUT 5 (electroneutral
pathway) or SGLT1 and SGLT3 (electrogenic pathway)
increase - AnswersOnce glucose has entered into the K cell, this will ___ the ATP/ADP ratio, by
generating more energy
Katp channel - AnswersAn increase in ATP in the K cell inhibits the ___ channel, depolarizing the cell
does not - AnswersThe Surface Detection pathway ___ transport things into the cell directly
SGLT3 - AnswersThe Surface Detection pathway of glucose in K cells, via electrogenic path, involves the
___ transporter
Tas - AnswersThe Surface Detection pathway of glucose in K cells, via electroneutral path, involves the
___ receptor
amino acid
glucose - AnswersThe SGLT3 transporter has ___ changes, stopping it from transporting glucose into the
cell, and instead acts as a ___ sensor
SGLT3 transporter
Cl - AnswersGlucose binding to the ___ will help depolarize the cell and ___ is transported out of the cell
glucose and sucrose - AnswersTas receptors are taste receptors that bind to things like ___ and ___
cAMP - AnswersThe Tas receptor is a G-protein coupled receptor that activates adenylyl cyclase to make
___
Vg Ca - AnswersThe net effect of the uptake and surface detection pathways and their mechanisms is to
depolarize the membrane helping to open Vg Na channels and primarily ___ channels
Ca
cAMP - AnswersIncreases in intracellular ___ and ___ promotes exocytosis of GIP granules
nutrients and GIP - AnswersGLP-1 secretion is stimulated by ___ and ___
GLP-1 - Answers___ release is stimulated by a 2 phase wave of stimulation
glucose-dependent insulinotropic peptide - AnswersGIP
Oral - Answers___ glucose gives greater insulin response than IV, IP, or SC
reduced - AnswersThere is a ____ incretin effect in people with Type 2 Diabetes
Food - Answers___ stimulates incretin secretion
7-36 - AnswersThe bioactive form of GLP-1 is (___) amide
1-42 - AnswersThe bioactive form of GIP is (___)
GLP-1
GIP - AnswersDPP-4 converts ___ and ___ to their inactive metabolites
N - AnswersDPP-4 cleaves off at the ___-terminus of each (GLP-1 and GIP), inactivating them
2 - AnswersDPP-4 cleaves off the first ___ amino acids of GIP and GLP-1, deactivating them
portal
systemic - AnswersDPP-4 is widely expressed, including on the surface of ___ endothelial cells so a large
proportion o GLP-1 and GIP never reach the ___ circulation
9-36
3-42 - AnswersThe inactive form of GLP-1 is (___) amide and the inactive form of GIP is (____)
GIP - AnswersK cells release ___
duodenum - AnswersK cells are primarily found in the ___
GLP-1 - AnswersL cells release ___
ileum and colon - AnswersL cells are found distally, in the ___ and ___
peripheral - AnswersGIP actions occur in ___ tissues
GIP and GLP-1 - AnswersThe incretin effect is lost after ___ and ___ are proteolyzed by DPP-4
nutrients - AnswersGIP secretion is stimulated by ___
depolarization
GIP - AnswersWhen K cells sense nutrients, they promote ___ of the membrane, causing an increase of
Ca2+ into the cell to release ___
, directly - AnswersThe Uptake pathway ___ takes up glucose and ions
2 and 5 - AnswersThe Uptake pathway of glucose via the electroneutral pathway into K cells occurs
through the GLUT___ and GLUT___ transporters
1 and 3 - AnswersThe Uptake pathway of glucose via the electrogenic pathway into K cells occurs
through SGLT___ and SGLT___
- Answers___ of glucose into the K cell occurs via the transporters GLUT2 and GLUT 5 (electroneutral
pathway) or SGLT1 and SGLT3 (electrogenic pathway)
increase - AnswersOnce glucose has entered into the K cell, this will ___ the ATP/ADP ratio, by
generating more energy
Katp channel - AnswersAn increase in ATP in the K cell inhibits the ___ channel, depolarizing the cell
does not - AnswersThe Surface Detection pathway ___ transport things into the cell directly
SGLT3 - AnswersThe Surface Detection pathway of glucose in K cells, via electrogenic path, involves the
___ transporter
Tas - AnswersThe Surface Detection pathway of glucose in K cells, via electroneutral path, involves the
___ receptor
amino acid
glucose - AnswersThe SGLT3 transporter has ___ changes, stopping it from transporting glucose into the
cell, and instead acts as a ___ sensor
SGLT3 transporter
Cl - AnswersGlucose binding to the ___ will help depolarize the cell and ___ is transported out of the cell
glucose and sucrose - AnswersTas receptors are taste receptors that bind to things like ___ and ___
cAMP - AnswersThe Tas receptor is a G-protein coupled receptor that activates adenylyl cyclase to make
___
Vg Ca - AnswersThe net effect of the uptake and surface detection pathways and their mechanisms is to
depolarize the membrane helping to open Vg Na channels and primarily ___ channels
Ca
cAMP - AnswersIncreases in intracellular ___ and ___ promotes exocytosis of GIP granules
nutrients and GIP - AnswersGLP-1 secretion is stimulated by ___ and ___
GLP-1 - Answers___ release is stimulated by a 2 phase wave of stimulation
