Page 1 of 822
TEST BANK c
Katzung's Basic and Clinical Pharm
c c c c
acology, 16th Edition c c c
by Todd W. Vanderah, Chapters 1 - 66
c c c c c c c c
Katzung's Basic and Clinical Pharmacology
, Page 2 of 822
Table ctxcofctxcContents
1.ctxcIntroduction:ctxcThectxcNaturectxcofctxcDrugsctxc&ctxcDrugctxcDevelopmentctxc&ctxcRegulation
2.ctxcDrugctxcReceptorsctxc&ctxcPharmacodynamics
3.ctxcPharmacokineticsctxc&ctxcPharmacodynamics:ctxcRationalctxcDosingctxc&ctxcthectxcTimectxcCoursectxcofctxcDrugctxcAction
4.ctxcDrugctxcBiotransformation
5.ctxcPharmacogenomics
6.ctxcIntroductionctxctoctxcAutonomicctxcPharmacology
7.ctxcCholinoceptor-Activatingctxc&ctxcCholinesterase-InhibitingctxcDrugs
8.ctxcCholinoceptor-BlockingctxcDrugs
9.ctxcAdrenoceptorctxcAgonistsctxc&ctxcSympathomimetic ctxcDrugs
10.ctxcAdrenoceptorctxcAntagonistctxcDrugs
11.ctxcAntihypertensivectxcAgents
12.ctxcVasodilatorsctxc&ctxcthectxcTreatmentctxcofctxcAnginactxcPectoris
13.ctxcDrugsctxcUsedctxcinctxcHeartctxcFailure
14.ctxcAgentsctxcUsedctxcinctxcCardiacctxcArrhythmias
15.ctxcDiureticctxcAgents
16.ctxcHistamine,ctxcSerotonin,ctxc&ctxcthectxcErgotctxcAlkaloids
17.ctxcVasoactivectxcPeptides
18.ctxcThectxcEicosanoids:ctxcProstaglandins,ctxcThromboxanes,ctxcLeukotrienes,ctxc&ctxcRelatedctxcCompounds
19.ctxcNitricctxcOxide
20.ctxcDrugsctxcUsedctxcinctxcAsthma
21.ctxcIntroductionctxctoctxcthectxcPharmacologyctxcofctxcCNSctxcDrugs
22.ctxcSedative-HypnoticctxcDrugs
23.ctxcThectxcAlcohols
24.ctxcAntiseizure ctxcDrugs
25.ctxcGeneralctxcAnesthetics
26.ctxcLocalctxcAnesthetics
27.ctxcSkeletalctxcMusclectxcRelaxants
28.ctxcPharmacologic ctxcManagementctxcofctxcParkinsonismctxc&ctxcOtherctxcMovementctxcDisorders
29.ctxcAntipsychotic ctxcAgentsctxc&ctxcLithium
30.ctxcAntidepressantctxcAgents
31.ctxcOpioidctxcAgonistsctxc&ctxcAntagonists
32.ctxcDrugsctxcofctxcAbuse
33.ctxcAgentsctxcUsedctxcinctxcCytopenias;ctxcHematopoieticctxcGrowthctxcFactors
34.ctxcDrugsctxcUsedctxcinctxcDisordersctxcofctxcCoagulation
35.ctxcAgentsctxcUsedctxcinctxcDyslipidemia
36.ctxcNonsteroidalctxcAnti-InflammatoryctxcDrugs,ctxcDisease-ModifyingctxcAntirheumaticctxcDrugs,ctxcNonopioidctxcAnalgesics,ctxc&ctxcDrugsctxcUsedctxcinctxcGout
37.ctxcHypothalamicctxc&ctxcPituitaryctxcHormones
38.ctxcThyroidctxc&ctxcAntithyroidctxcDrugs
39.ctxcAdrenocorticosteroids ctxc&ctxcAdrenocorticalctxcAntagonists
40.ctxcThectxcGonadal ctxcHormonesctxc&ctxcInhibitors
41.ctxcPancreaticctxcHormonesctxc&ctxcAntidiabetic ctxcDrugs
42.ctxcAgentsctxcThatctxcAffectctxcBonectxcMineralctxcHomeostasis
43.ctxcBeta-Lactamctxc&ctxcOtherctxcCellctxcWall-ctxc&ctxcMembrane-ActivectxcAntibiotics
44.ctxcTetracyclines,ctxcMacrolides,ctxcClindamycin,ctxcChloramphenicol,ctxcStreptogramins,ctxc&ctxcOxazolidinones
45.ctxcAminoglycosidesctxc&ctxcSpectinomycin
46.ctxcSulfonamides,ctxcTrimethoprim,ctxc&ctxcQuinolones
47.ctxcAntimycobacterialctxcDrugs
48.ctxcAntifungalctxcAgents
49.ctxcAntiviralctxcAgents
50.ctxcMiscellaneousctxcAntimicrobialctxcAgents;ctxcDisinfectants,ctxcAntiseptics,ctxc&ctxcSterilants
51.ctxcClinicalctxcUsectxcofctxcAntimicrobialctxcAgents
52.ctxcAntiprotozoalctxcDrugs
53.ctxcClinicalctxcPharmacologyctxcofctxcthectxcAntihelminthicctxcDrugs
54.ctxcCancerctxcChemotherapy
55.ctxcImmunopharmacology
56. ctxcIntroductionctxctoctxcToxicology:ctxcOccupationalctxc&ctxcEnvironmental
57. ctxcHeavyctxcMetalctxcIntoxicationctxc&ctxcChelators
58. ctxcManagementctxcofctxcthectxcPoisonedctxcPatient
59.ctxcSpecialctxcAspectsctxcofctxcPerinatalctxc&ctxcPediatricctxcPharmacology
60.ctxcSpecialctxcAspectsctxcofctxcGeriatricctxcPharmacology
61.ctxcDermatologic ctxcPharmacology
62.ctxcDrugsctxcUsedctxcinctxcthectxcTreatmentctxcofctxcGastrointestinalctxcDiseases
63.ctxcTherapeuticctxc&ctxcToxicctxcPotentialctxcofctxcOver-the-CounterctxcAgents
64.ctxcDietaryctxcSupplementsctxc&ctxcHerbalctxcMedications
65.ctxcRationalctxcPrescribingctxc& ctxcPrescriptionctxcWriting
66.ctxcImportantctxcDrugctxcInteractionsctxc&ctxcTheirctxcMechanismsctxc
Chapter ctxc1.ctxcIntroduction:ctxcThectxcNaturectxcofctxcDrugsctxc&ctxcDrugctxcDevelopmentctxc&ctxcRegulation
Katzung's Basic and Clinical Pharmacology
, Page 3 of 822
1.
Acnursecworkingcincradiologycadministersciodinectocacpatientcwhocischavingca
ccomputedctomographyc(CT)cscan.cThecnursecworkingconctheconcologycunitcad
ministerscchemotherapyctocpatientscwhochaveccancer.cAtcthecPubliccHealthcDep
artment,cacnursecadministerscacmeasles-mumps-rubellac(MMR)cvaccinectocac14-
month-
oldcchildcascacroutinecimmunization.cWhichcbranchcofcpharmacologycbestcdescr
ibescthecactionscofcallcthreec nurses?
A) Pharmacoeconomics
B) Pharmacotherapeutics
C) Pharmacodynamics
D) Pharmacokinetics
ANSWER: B
Feedback:
Pharmacologyciscthecstudycofcthecbiologicceffectscofcchemicals.cNursescarecinvo
lvedcwithcclinicalcpharmacologycorcpharmacotherapeutics,cwhichciscacbranchcof
cpharmacologycthatcdealscwithcthecusescofcdrugsctoctreat,cprevent,candcdiagnosec
disease.cThecradiologycnurseciscadministeringcacdrugctochelpcdiagnosecacdisease
.cTheconcologycnurseciscadministeringcacdrugctochelpctreatcacdisease.cPharmacoe
conomicscincludescanyccostscinvolvedcincdrugc therapy.
Pharmacodynamicscinvolveschowcacdrugcaffectscthecbodycandcp
harmacokineticscischowcthecbodycactsconcthecbody.
2.
Acphysicianchascorderedcintramuscularc(IM)cinjectionscofcmorphine,cacnarco
tic,ceveryc4chourscascneededcforcpaincincacmotorcvehiclecaccidentcvictim.cThecnu
rseciscawarecthiscdrugchascachighcabusecpotential.cUndercwhatccategorycwouldcm
orphinecbecclassified?
A) SchedulecI
B) SchedulecII
Katzung's Basic and Clinical Pharmacology
, Page 4 of 822
C) SchedulecIII
D) SchedulecIV
ANSWER: B
Feedback:
NarcoticscwithcachighcabusecpotentialcarecclassifiedcascSchedulecIIcdrugscbecau
secofcseverecdependencecliability.cSchedulecIcdrugschavechighcabusecpotentialc
andcnocacceptedcmedicalcuse.cSchedulecIIIcdrugschavecaclessercabusecpotentialc
thancIIcandcancacceptedcmedicalcuse.cSchedulecIVcdrugschaveclowcabusecpotent
ialcandclimitedcdependencec liability.
3.
WhencinvolvedcincphasecIIIcdrugcevaluationcstudies,cwhatcresponsibilitie
scwouldcthecnursechave?
A) Workingcwithcanimalscwhocarecgivencexperimentalc drugs
B) Choosingcappropriatecpatientsctocbecinvolvedcincthecdrugc study
C) Monitoringcandcobservingcpatientsccloselycforcadversec effects
D) Conductingcresearchctocdetermineceffectivenesscofcthec drug
ANSWER: C
Feedback:
PhasecIIIcstudiescinvolvecusecofcacdrugcincacvastcclinicalcpopulationcincwhichcp
atientscarecaskedctocrecordcanycsymptomsctheycexperiencecwhilectakingcthecdr
ugs.cNursescmaycbecresponsiblecforchelpingccollectcandcanalyzecthecinformati
onctocbecsharedcwithcthecFoodcandcDrugcAdministrationc(FDA)cbutcwouldcnotc
conductcresearchcindependentlycbecausecnursescdocnotcprescribecmedications
.cUsecofcanimalscincdrugctestingciscdonecincthecpreclinicalctrials.cSelectcpatients
cwhocarecinvolvedcincphasecIIcstudiesctocparticipatecincstudiescwherecthecpartic
ipantschavecthecdiseasecthecdrugciscintendedctoctreat.cThesecpatientscarecmonit
oredccloselycforcdrugcactioncandcadverseceffects.cPhasecIcstudiescinvolvechealt
hychumancvolunteerscwhocarecusuallycpaidcforctheircparticipation.cNursescmay
cobservecforcadverseceffectscandctoxicity.
4.
Whatcconceptciscconsideredcwhencgenericcdrugscarecsubstitutedcforcbran
dcnamecdrugs?
Katzung's Basic and Clinical Pharmacology
TEST BANK c
Katzung's Basic and Clinical Pharm
c c c c
acology, 16th Edition c c c
by Todd W. Vanderah, Chapters 1 - 66
c c c c c c c c
Katzung's Basic and Clinical Pharmacology
, Page 2 of 822
Table ctxcofctxcContents
1.ctxcIntroduction:ctxcThectxcNaturectxcofctxcDrugsctxc&ctxcDrugctxcDevelopmentctxc&ctxcRegulation
2.ctxcDrugctxcReceptorsctxc&ctxcPharmacodynamics
3.ctxcPharmacokineticsctxc&ctxcPharmacodynamics:ctxcRationalctxcDosingctxc&ctxcthectxcTimectxcCoursectxcofctxcDrugctxcAction
4.ctxcDrugctxcBiotransformation
5.ctxcPharmacogenomics
6.ctxcIntroductionctxctoctxcAutonomicctxcPharmacology
7.ctxcCholinoceptor-Activatingctxc&ctxcCholinesterase-InhibitingctxcDrugs
8.ctxcCholinoceptor-BlockingctxcDrugs
9.ctxcAdrenoceptorctxcAgonistsctxc&ctxcSympathomimetic ctxcDrugs
10.ctxcAdrenoceptorctxcAntagonistctxcDrugs
11.ctxcAntihypertensivectxcAgents
12.ctxcVasodilatorsctxc&ctxcthectxcTreatmentctxcofctxcAnginactxcPectoris
13.ctxcDrugsctxcUsedctxcinctxcHeartctxcFailure
14.ctxcAgentsctxcUsedctxcinctxcCardiacctxcArrhythmias
15.ctxcDiureticctxcAgents
16.ctxcHistamine,ctxcSerotonin,ctxc&ctxcthectxcErgotctxcAlkaloids
17.ctxcVasoactivectxcPeptides
18.ctxcThectxcEicosanoids:ctxcProstaglandins,ctxcThromboxanes,ctxcLeukotrienes,ctxc&ctxcRelatedctxcCompounds
19.ctxcNitricctxcOxide
20.ctxcDrugsctxcUsedctxcinctxcAsthma
21.ctxcIntroductionctxctoctxcthectxcPharmacologyctxcofctxcCNSctxcDrugs
22.ctxcSedative-HypnoticctxcDrugs
23.ctxcThectxcAlcohols
24.ctxcAntiseizure ctxcDrugs
25.ctxcGeneralctxcAnesthetics
26.ctxcLocalctxcAnesthetics
27.ctxcSkeletalctxcMusclectxcRelaxants
28.ctxcPharmacologic ctxcManagementctxcofctxcParkinsonismctxc&ctxcOtherctxcMovementctxcDisorders
29.ctxcAntipsychotic ctxcAgentsctxc&ctxcLithium
30.ctxcAntidepressantctxcAgents
31.ctxcOpioidctxcAgonistsctxc&ctxcAntagonists
32.ctxcDrugsctxcofctxcAbuse
33.ctxcAgentsctxcUsedctxcinctxcCytopenias;ctxcHematopoieticctxcGrowthctxcFactors
34.ctxcDrugsctxcUsedctxcinctxcDisordersctxcofctxcCoagulation
35.ctxcAgentsctxcUsedctxcinctxcDyslipidemia
36.ctxcNonsteroidalctxcAnti-InflammatoryctxcDrugs,ctxcDisease-ModifyingctxcAntirheumaticctxcDrugs,ctxcNonopioidctxcAnalgesics,ctxc&ctxcDrugsctxcUsedctxcinctxcGout
37.ctxcHypothalamicctxc&ctxcPituitaryctxcHormones
38.ctxcThyroidctxc&ctxcAntithyroidctxcDrugs
39.ctxcAdrenocorticosteroids ctxc&ctxcAdrenocorticalctxcAntagonists
40.ctxcThectxcGonadal ctxcHormonesctxc&ctxcInhibitors
41.ctxcPancreaticctxcHormonesctxc&ctxcAntidiabetic ctxcDrugs
42.ctxcAgentsctxcThatctxcAffectctxcBonectxcMineralctxcHomeostasis
43.ctxcBeta-Lactamctxc&ctxcOtherctxcCellctxcWall-ctxc&ctxcMembrane-ActivectxcAntibiotics
44.ctxcTetracyclines,ctxcMacrolides,ctxcClindamycin,ctxcChloramphenicol,ctxcStreptogramins,ctxc&ctxcOxazolidinones
45.ctxcAminoglycosidesctxc&ctxcSpectinomycin
46.ctxcSulfonamides,ctxcTrimethoprim,ctxc&ctxcQuinolones
47.ctxcAntimycobacterialctxcDrugs
48.ctxcAntifungalctxcAgents
49.ctxcAntiviralctxcAgents
50.ctxcMiscellaneousctxcAntimicrobialctxcAgents;ctxcDisinfectants,ctxcAntiseptics,ctxc&ctxcSterilants
51.ctxcClinicalctxcUsectxcofctxcAntimicrobialctxcAgents
52.ctxcAntiprotozoalctxcDrugs
53.ctxcClinicalctxcPharmacologyctxcofctxcthectxcAntihelminthicctxcDrugs
54.ctxcCancerctxcChemotherapy
55.ctxcImmunopharmacology
56. ctxcIntroductionctxctoctxcToxicology:ctxcOccupationalctxc&ctxcEnvironmental
57. ctxcHeavyctxcMetalctxcIntoxicationctxc&ctxcChelators
58. ctxcManagementctxcofctxcthectxcPoisonedctxcPatient
59.ctxcSpecialctxcAspectsctxcofctxcPerinatalctxc&ctxcPediatricctxcPharmacology
60.ctxcSpecialctxcAspectsctxcofctxcGeriatricctxcPharmacology
61.ctxcDermatologic ctxcPharmacology
62.ctxcDrugsctxcUsedctxcinctxcthectxcTreatmentctxcofctxcGastrointestinalctxcDiseases
63.ctxcTherapeuticctxc&ctxcToxicctxcPotentialctxcofctxcOver-the-CounterctxcAgents
64.ctxcDietaryctxcSupplementsctxc&ctxcHerbalctxcMedications
65.ctxcRationalctxcPrescribingctxc& ctxcPrescriptionctxcWriting
66.ctxcImportantctxcDrugctxcInteractionsctxc&ctxcTheirctxcMechanismsctxc
Chapter ctxc1.ctxcIntroduction:ctxcThectxcNaturectxcofctxcDrugsctxc&ctxcDrugctxcDevelopmentctxc&ctxcRegulation
Katzung's Basic and Clinical Pharmacology
, Page 3 of 822
1.
Acnursecworkingcincradiologycadministersciodinectocacpatientcwhocischavingca
ccomputedctomographyc(CT)cscan.cThecnursecworkingconctheconcologycunitcad
ministerscchemotherapyctocpatientscwhochaveccancer.cAtcthecPubliccHealthcDep
artment,cacnursecadministerscacmeasles-mumps-rubellac(MMR)cvaccinectocac14-
month-
oldcchildcascacroutinecimmunization.cWhichcbranchcofcpharmacologycbestcdescr
ibescthecactionscofcallcthreec nurses?
A) Pharmacoeconomics
B) Pharmacotherapeutics
C) Pharmacodynamics
D) Pharmacokinetics
ANSWER: B
Feedback:
Pharmacologyciscthecstudycofcthecbiologicceffectscofcchemicals.cNursescarecinvo
lvedcwithcclinicalcpharmacologycorcpharmacotherapeutics,cwhichciscacbranchcof
cpharmacologycthatcdealscwithcthecusescofcdrugsctoctreat,cprevent,candcdiagnosec
disease.cThecradiologycnurseciscadministeringcacdrugctochelpcdiagnosecacdisease
.cTheconcologycnurseciscadministeringcacdrugctochelpctreatcacdisease.cPharmacoe
conomicscincludescanyccostscinvolvedcincdrugc therapy.
Pharmacodynamicscinvolveschowcacdrugcaffectscthecbodycandcp
harmacokineticscischowcthecbodycactsconcthecbody.
2.
Acphysicianchascorderedcintramuscularc(IM)cinjectionscofcmorphine,cacnarco
tic,ceveryc4chourscascneededcforcpaincincacmotorcvehiclecaccidentcvictim.cThecnu
rseciscawarecthiscdrugchascachighcabusecpotential.cUndercwhatccategorycwouldcm
orphinecbecclassified?
A) SchedulecI
B) SchedulecII
Katzung's Basic and Clinical Pharmacology
, Page 4 of 822
C) SchedulecIII
D) SchedulecIV
ANSWER: B
Feedback:
NarcoticscwithcachighcabusecpotentialcarecclassifiedcascSchedulecIIcdrugscbecau
secofcseverecdependencecliability.cSchedulecIcdrugschavechighcabusecpotentialc
andcnocacceptedcmedicalcuse.cSchedulecIIIcdrugschavecaclessercabusecpotentialc
thancIIcandcancacceptedcmedicalcuse.cSchedulecIVcdrugschaveclowcabusecpotent
ialcandclimitedcdependencec liability.
3.
WhencinvolvedcincphasecIIIcdrugcevaluationcstudies,cwhatcresponsibilitie
scwouldcthecnursechave?
A) Workingcwithcanimalscwhocarecgivencexperimentalc drugs
B) Choosingcappropriatecpatientsctocbecinvolvedcincthecdrugc study
C) Monitoringcandcobservingcpatientsccloselycforcadversec effects
D) Conductingcresearchctocdetermineceffectivenesscofcthec drug
ANSWER: C
Feedback:
PhasecIIIcstudiescinvolvecusecofcacdrugcincacvastcclinicalcpopulationcincwhichcp
atientscarecaskedctocrecordcanycsymptomsctheycexperiencecwhilectakingcthecdr
ugs.cNursescmaycbecresponsiblecforchelpingccollectcandcanalyzecthecinformati
onctocbecsharedcwithcthecFoodcandcDrugcAdministrationc(FDA)cbutcwouldcnotc
conductcresearchcindependentlycbecausecnursescdocnotcprescribecmedications
.cUsecofcanimalscincdrugctestingciscdonecincthecpreclinicalctrials.cSelectcpatients
cwhocarecinvolvedcincphasecIIcstudiesctocparticipatecincstudiescwherecthecpartic
ipantschavecthecdiseasecthecdrugciscintendedctoctreat.cThesecpatientscarecmonit
oredccloselycforcdrugcactioncandcadverseceffects.cPhasecIcstudiescinvolvechealt
hychumancvolunteerscwhocarecusuallycpaidcforctheircparticipation.cNursescmay
cobservecforcadverseceffectscandctoxicity.
4.
Whatcconceptciscconsideredcwhencgenericcdrugscarecsubstitutedcforcbran
dcnamecdrugs?
Katzung's Basic and Clinical Pharmacology
