NRNP 6566 WK1-5 Midterm | 2025 LATEST UPDATED|
COMPLETE QUESTIONS AND ANSWERS | 100% RATED
CORRECT | 100% VERFIED | ALREADY GRADED A+|GET A+
Describe cytochrome p450 system - (answer)Cytochrome p450 system is a series
of enzymes used to metabolize medications
Inhibitors - (answer)block metabolic activity from one or more CYP450 enzymes
Inducers - (answer)increase CYP450 enzyme activity by increasing enzyme
synthesis
Describe effect on low and high albumin levels on active drug levels especially for
drugs that are highly protein bound - (answer)Albumin is the plasma protein with
the greatest capacity for binding drugs. Binding plasma proteins affect drug
distribution into tissues, because only drug that is not bound is available to
penetrate tissues, bind to receptors, and exert activity. As free drug leaves the blood
stream, more bound drug is released from binding sites.
, Low albumin levels - (answer)malnutrition, chronic illness
Highly protein bound drugs can lead to - (answer)toxicity in patients with low
albumin levels, example malnutrition or chronic illness. This is because there are
fewer than the normal sites for the drug to bind
Describe the ways the hepatic first pass effect- which is metabolism during first
pass through the liver - (answer)Alternative routes include:
suppository
intravenous
intramuscular
inhalational aerosol
transdermal
sublingual
These allow drugs to bypass the first-pass effect and be absorbed directly into
systemic circulation
COMPLETE QUESTIONS AND ANSWERS | 100% RATED
CORRECT | 100% VERFIED | ALREADY GRADED A+|GET A+
Describe cytochrome p450 system - (answer)Cytochrome p450 system is a series
of enzymes used to metabolize medications
Inhibitors - (answer)block metabolic activity from one or more CYP450 enzymes
Inducers - (answer)increase CYP450 enzyme activity by increasing enzyme
synthesis
Describe effect on low and high albumin levels on active drug levels especially for
drugs that are highly protein bound - (answer)Albumin is the plasma protein with
the greatest capacity for binding drugs. Binding plasma proteins affect drug
distribution into tissues, because only drug that is not bound is available to
penetrate tissues, bind to receptors, and exert activity. As free drug leaves the blood
stream, more bound drug is released from binding sites.
, Low albumin levels - (answer)malnutrition, chronic illness
Highly protein bound drugs can lead to - (answer)toxicity in patients with low
albumin levels, example malnutrition or chronic illness. This is because there are
fewer than the normal sites for the drug to bind
Describe the ways the hepatic first pass effect- which is metabolism during first
pass through the liver - (answer)Alternative routes include:
suppository
intravenous
intramuscular
inhalational aerosol
transdermal
sublingual
These allow drugs to bypass the first-pass effect and be absorbed directly into
systemic circulation
