BIO 338
BIO 338 IUPUI Immunology Lecture Final
Exam
what does HIV have on Surface - Gp120 and Gp41
What things does HIV NEED to attach to to infiltrate cell - CD4+ and (CXCR4 If
attaching to T cell) OR (CCr5 if attaching to Macrophage)
Brutens XLA - no Antibodies, defect with pre B cell, cannot go past Pre B cell stage. No
MATURE B CELLS,
CANNOT respond to signals
X-linked hyper IgM syndrome (HIS) - no Igg, Iga, Ige But too many IGM
cannot class switch
problem with CD40L
X-linked SCID - Problems with Il2, (activation of T and B cells)
Inhibits B and T cell maturation
Must receive Bone marrow transplant to live
Type 1 BLS - No type 1 MHC
only Gamma and Delta Cytotoxic T Cells
BIO 338
, BIO 338
What do Tap 1 and 2 do - Move peptide from cytosol to RER to be loaded on MHC 1 and
presented on surface of cell
Type 2 BLS - No MHC class 2
no CD4+ T helper cells
ONLY HAVE IGM
CANNOT CLASS SWITCH
NEED BONE MARROW TRANSPLANT TO LIVE
Graves disease - hyperthyroidism,
too much T3 and T4
Hashimoto's disease - hypothyroidism; antibody made that acts as an antagonist to TSH
receptor (Ab-TSH); therefore, decrease in T3 and T4; decrease in negative feedback;
increase in TRH and increase in TSH
ISCOM - immune stimulating complex
Very expensive vaccine,
allows for cell mediated response to antigen
creates memory
active immunity - A form of acquired immunity in which the body produces its own
antibodies against disease-causing antigens
BIO 338
BIO 338 IUPUI Immunology Lecture Final
Exam
what does HIV have on Surface - Gp120 and Gp41
What things does HIV NEED to attach to to infiltrate cell - CD4+ and (CXCR4 If
attaching to T cell) OR (CCr5 if attaching to Macrophage)
Brutens XLA - no Antibodies, defect with pre B cell, cannot go past Pre B cell stage. No
MATURE B CELLS,
CANNOT respond to signals
X-linked hyper IgM syndrome (HIS) - no Igg, Iga, Ige But too many IGM
cannot class switch
problem with CD40L
X-linked SCID - Problems with Il2, (activation of T and B cells)
Inhibits B and T cell maturation
Must receive Bone marrow transplant to live
Type 1 BLS - No type 1 MHC
only Gamma and Delta Cytotoxic T Cells
BIO 338
, BIO 338
What do Tap 1 and 2 do - Move peptide from cytosol to RER to be loaded on MHC 1 and
presented on surface of cell
Type 2 BLS - No MHC class 2
no CD4+ T helper cells
ONLY HAVE IGM
CANNOT CLASS SWITCH
NEED BONE MARROW TRANSPLANT TO LIVE
Graves disease - hyperthyroidism,
too much T3 and T4
Hashimoto's disease - hypothyroidism; antibody made that acts as an antagonist to TSH
receptor (Ab-TSH); therefore, decrease in T3 and T4; decrease in negative feedback;
increase in TRH and increase in TSH
ISCOM - immune stimulating complex
Very expensive vaccine,
allows for cell mediated response to antigen
creates memory
active immunity - A form of acquired immunity in which the body produces its own
antibodies against disease-causing antigens
BIO 338
