WEEK 1 WALDEN 6501 ADVANCED PATHOPHYSIOLOGY
QUESTIONS WITH CORRECT ANSWERS 2025/2026
Acrocentric - CORRECT ANSWER -refers to the terminal location of centromere on chromosomes
13, 14, 15, 21, and 22
Allelic heterogeneity - CORRECT ANSWER -the situation in which multiple alleles at a single locus
can produce one or more disease phenotypes.
Amorphic - CORRECT ANSWER -refers ro mutations that cause a complete loss of function for
the respective gene, and therefore yield the same phenotype as a complete gene deletion.
Aneuploidy - CORRECT ANSWER -a general term used to denote any unbalanced chromosome
complement
Antimorphic - CORRECT ANSWER -refers to mutations that when present in heterozygous form
opposite a nonmutant allele will result in a phenotype similar to homozygous for loss of
function alleles.
Ascertainment bias - CORRECT ANSWER -the situation in which individuals or families in a
genetic study are not representative of the general population because of the way in which they
are identified
Autosomal - CORRECT ANSWER -located on chromosomes 1-22 rather than x or y
Cpg island - CORRECT ANSWER -a segment of DNA that contains a relatively high density of 5' -
CG-3' dinucleotides. Such segments are frequently unmethylated and located close to
ubiquitously expressed genes.
QUESTIONS WITH CORRECT ANSWERS 2025/2026
Acrocentric - CORRECT ANSWER -refers to the terminal location of centromere on chromosomes
13, 14, 15, 21, and 22
Allelic heterogeneity - CORRECT ANSWER -the situation in which multiple alleles at a single locus
can produce one or more disease phenotypes.
Amorphic - CORRECT ANSWER -refers ro mutations that cause a complete loss of function for
the respective gene, and therefore yield the same phenotype as a complete gene deletion.
Aneuploidy - CORRECT ANSWER -a general term used to denote any unbalanced chromosome
complement
Antimorphic - CORRECT ANSWER -refers to mutations that when present in heterozygous form
opposite a nonmutant allele will result in a phenotype similar to homozygous for loss of
function alleles.
Ascertainment bias - CORRECT ANSWER -the situation in which individuals or families in a
genetic study are not representative of the general population because of the way in which they
are identified
Autosomal - CORRECT ANSWER -located on chromosomes 1-22 rather than x or y
Cpg island - CORRECT ANSWER -a segment of DNA that contains a relatively high density of 5' -
CG-3' dinucleotides. Such segments are frequently unmethylated and located close to
ubiquitously expressed genes.
