NUSCTX 11- UC Berkeley Verified Multiple
Choice and Conceptual Actual Exam
Questions With Reviewed 100% Correct
Detailed Answers
Guaranteed Pass!!Current Update
1. What might occur to increase the toxicity of lipophilic chemicals? -
ANSWER Bioaccumulation and Phase I
2. What could be a specific way that toxicity from an oil spill is most harmful to
fish? - ANSWER Absorbs and bioaccumulates in fat, and can be
metabolized into carcinogens.
3. If a certain substance causes "DNA adducts" which experiments could you
try to detect it? - ANSWER Measure Phase II enzymes and hypothesize
that these enzymes are inhibited
Show that the chemical is a mimic for other nucleotides in DNA replication
Measure chemical metabolites in milk in female animals.
4. What is true about biotransformation? - ANSWER It is a 2-phase
process
It can decrease toxicity
It can increase toxicity, it makes compounds more hydrophilic (water soluble)
, 5. What are factors in calculating toxicant risk? - ANSWER Exposure
Absorption
Site of Action
6. Biological factors that determine toxicity? - ANSWER Absorption
Metabolism
Lipophilic character
Distribution (lymph system)
7. Circulatory path of lymph - ANSWER Route to fast entry into lungs and
blood
8. Circulatory path of bile duct - ANSWER Breaks down lipophilic
chemicals, enterohepatic circulation
9. Circulatory path of portal vein - ANSWER Routes for metabolism by CYP
in liver (gut to liver)
10.TD - ANSWER Toxic Dose
11.LD - ANSWER Lethal Dose
Choice and Conceptual Actual Exam
Questions With Reviewed 100% Correct
Detailed Answers
Guaranteed Pass!!Current Update
1. What might occur to increase the toxicity of lipophilic chemicals? -
ANSWER Bioaccumulation and Phase I
2. What could be a specific way that toxicity from an oil spill is most harmful to
fish? - ANSWER Absorbs and bioaccumulates in fat, and can be
metabolized into carcinogens.
3. If a certain substance causes "DNA adducts" which experiments could you
try to detect it? - ANSWER Measure Phase II enzymes and hypothesize
that these enzymes are inhibited
Show that the chemical is a mimic for other nucleotides in DNA replication
Measure chemical metabolites in milk in female animals.
4. What is true about biotransformation? - ANSWER It is a 2-phase
process
It can decrease toxicity
It can increase toxicity, it makes compounds more hydrophilic (water soluble)
, 5. What are factors in calculating toxicant risk? - ANSWER Exposure
Absorption
Site of Action
6. Biological factors that determine toxicity? - ANSWER Absorption
Metabolism
Lipophilic character
Distribution (lymph system)
7. Circulatory path of lymph - ANSWER Route to fast entry into lungs and
blood
8. Circulatory path of bile duct - ANSWER Breaks down lipophilic
chemicals, enterohepatic circulation
9. Circulatory path of portal vein - ANSWER Routes for metabolism by CYP
in liver (gut to liver)
10.TD - ANSWER Toxic Dose
11.LD - ANSWER Lethal Dose
