Test Bank for Immune System 4th Edition Parham

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,Immune System 4th Edition Parham Test Bank




THE IMMUNE SYSTEM, FOURTH EDITION
CHAPTER 3: INNATE IMMUNITY: THE INDUCED
RESPONSE TO INFECTION
© 2015 Garland Science


3–1 C-type lectins are so called because of the role of _____ in facilitating receptor:ligand
interactions.
a. carbohydrate
b. CR1
c. calcium
d. chemokines
e. caspases.

3–2 Lectins recognize microbial _____.
a. phosphate-containing lipoteichoic acids
b. nucleic acids
c. carbohydrates
d. flagellin
e. sulfated polysaccharides.

3–3 Scavenger receptor SR-B recognizes _____.
a. lipopolysaccharides
b. teichoic acid
c. filamentous hemagglutinin
d. CpG-rich bacterial DNA
e. lipids.

3–4 Macrophages bear on their surface receptors for all of the following except _____. (Select
all that apply).
a. mannose
b. glucans
c. C3b
d. muramyl dipeptide
e. lipopolysaccharide
f. lipoteichoic acid
g. CpG-rich bacterial DNA.

3–5 _____ is a soluble protein. (Select all that apply.)
a. TLR4
b. CD14
c. lipopolysaccharide-binding protein (LBP)
d. CXCR1
e. mannose-binding lectin.


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,3–6 _____ are structurally similar membrane-bound proteins that aid in the adhesion between
various types of human cell.
a. Interferons
b. Integrins
c. GTP-binding proteins
d. Pyrogens
e. Pentraxins.

3–7 All of the following induce fever except _____.
a. IL-12
b. IL-6
c. IL-1
d. TNF-\alpha.

3–8 Match the term in column A with its description in column B.

Column A Column B
___a. interferon response 1. a notable rise or reduction of plasma
proteins in response to IL-6
___b. apoptosis 2. stimulates inhibition of viral replication
___c. extravasation 3. temporary rise in oxygen consumption and
toxic oxygen species production
___d. respiratory burst 4. cellular suicide characterized by DNA
fragmentation
___e. acute-phase response 5. migration of neutrophils into inflamed
tissues

3–9 Which of the following is not associated with mobilization of neutrophils to infected
tissue?
a. TNF-\alpha production by macrophages
b. upregulation of selectins on blood vessel endothelium
c. interferon response
d. generation of a CXCL8 gradient
e. extravasation across endothelium
f. proteolysis of basement membrane of blood vessels.

3–10 Which of the following pairs is mismatched?
a. primary granules: azurophilic granules
b. secondary granules: unsaturated lactoferrin
c. azurophilic granules: myeloperoxidase
d. gelatinase: iron sequestration
e. tertiary granules: natural killer cells.

3–11 The pH of the phagosome increases following phagocytosis because _____.
a. the microbe delivers a significant number of hydroxyl ions in its cytosol that are released
upon membrane disruption

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, b. hydrogen ions are eliminated by the activity of NADPH oxidase and superoxide
dismutase
c. azurophilic granules deliver alkaline substances
d. catalase consumes hydrogen ions once activated.

3–12 C-reactive protein binds to _____.
a. phosphorylcholine
b. mannose-containing carbohydrates
c. lipoteichoic acid
d. flagellin
e. MASP-1/MASP-2.

3–13 The C3 convertase that functions in the lectin pathway of complement activation consists
of _____.
a. C3bBb
b. C3b2a
c. C4b2a
d. C4b2b
e. C3b2Bb.

3–14 Which of the following cleaves C2? (Select all that apply.)
a. Factor B
b. C1r
c. MASP-2
d. C1s
e. C4b.

3–15 With which of the following complement proteins does C-reactive protein interact?
a. factor D
b. C1
c. factor P
d. C4
e. C2.

3–16 All of the following are true of MyD88 except _____.
a. It binds to the TIR domains of all Toll-like receptors except TLR3.
b. It binds to IRAK4, a protein kinase, causing the kinase to phosphorylate itself.
c. It is an adaptor protein with similar function to TRIF.
d. A genetic deficiency of MyD88 causes the disease X-linked ectodermal dysplasia and
immunodeficiency.

3–17 The name given to cytokines that recruit cells to move towards areas of inflammation is
_____.
a. chemokines
b. caspase-recruitment domains (CARDs)
c. inflammakines

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