APEA Pharm Cardiovascular Exam with Questions and Verrified Answers

APEA Pharm Cardiovascular Exam with Questions and Verrified Answers


Bacterial protein synthesis inhibitors
Clindamycin




Clindamycin
Time dependent killing
Inhibits protein synthesis
Bacteriostatic
90% bioavailability




Clindamycin mechanism of resistance
Altered target sites
Active efflux (pushes drug out of the cell)




Clindamycin ADE
GI upset
Skin rash
Neutropenia
Superinfections such a c diff pseudomembranous
- don't use if patient has history of c diff




Clindamycin indications
Gram positive
Prophylaxis of endocarditis in valve patients with PCN allergy




Oxazolidinones
New class of bacterial protein synthesis inhibitors


Time dependent killing
Prevents formation of ribosome complex
Bacteriostatic & Bactericidal against strep




Linezolid
Protein synthesis inhibitor
100% bioavailability orally

, APEA Pharm Cardiovascular Exam with Questions and Verrified Answers


30% CSF penetration




Linezolid ADE
Hematologic
Increased thrombocytopenia risk
Anemia, neutropenia, neuropathy
Optic & peripheral neuropathy
Serotonin syndrome with SSRIs




Linezolid Indications
Gram positive resistant
VRE, HCAP, CAP
Complicated skin & tissue infections
Off label use for TB
No resistance currently




Fluoroquinolones
Norfloxacin (1st gen)
Ciprofloxacin & Ofloxacin (2nd gen)
Levofloxacin (3rd gen)
Moxifloxacin & Gemifloxacin (3rd gen respiratory)




Fluoroquinolones are classified by
Generations according to antimicrobial spectra




1st Generation Fluoroquinolone
Narrow gram negative
Norfloxacin




2nd Generation Fluoroquinolone
Broad- gram negative and gram positive
Cipro & ofloxacin