TEST BANK
Basic and Clinical Pharmacology by Bertram Katzung
15th Edition
TEST BANK
, Test Bank For Basic and Clinical Pharmacology 15th Edition by Bertram Katzung
Table of Contents:
Section I: Basic principles
Chapter 1: Introduction: the nature of drugs & drug development & regulation
Chapter 2: Drug receptors & pharmacodynamics
Chapter 3: Pharmacokinetics & pharmacodynamics: rational dosing & the time course of
drug action
Chapter 4: Drug biotransformation
Chapter 5: Pharmacogenomics
Section II: Autonomic drugs
Chapter 6: Introduction to autonomic pharmacology
Chapter 7: Cholinoceptor-activating & cholinesterase-inhibiting drugs
Chapter 8: Cholinoceptor-blocking drugs
Chapter 9: Adrenoceptor agonists & sympathomimetic drugs
Chapter 10: Adrenoceptor antagonist drugs
Section III: Cardiovascular-renal drugs
Chapter 11: Antihypertensive agents
Chapter 12: Vasodilators & the treatment of angina pectoris
Chapter 13: Drugs used in heart failure
Chapter 14: Agents used in cardiac arrhythmias
Chapter 15: Diuretic agents
Section IV: Drugs with important actions on smooth muscle
Chapter 16: Histamine, serotonin, & the ergot alkaloids
Chapter 17: Vasoactive peptides
Chapter 18: The Eicosanoids: prostaglandins, thromboxanes, leukotrienes, & related
compounds
Chapter 19: Nitric oxide
Chapter 20: Drugs used in asthma
Section V: Drugs that act in the central nervous system
Chapter 21: Introduction to the pharmacology of cns drugs
Chapter 22: Sedative-hypnotic drugs
Chapter 23: The Alcohols
Chapter 24: Antiseizure drugs
Chapter 25: General anesthetics
Chapter 26: Local anesthetics
Chapter 27: Skeletal muscle relaxants
Chapter 28: Pharmacologic management of parkinsonism & other movement disorders
Chapter 29: Antipsychotic agents & lithium
Chapter 30: Antidepressant agents
Chapter 31: Opioid agonists & antagonists
Chapter 32: Drugs of abuse
,Section VI: Drugs used to treat diseases of the blood, inflammation, & gout
Chapter 33: Agents used in cytopenias; hematopoietic growth factors
Chapter 34: Drugs used in disorders of coagulation
Chapter 35: Agents used in dyslipidemia
Chapter 36: Nonsteroidal anti-inflammatory drugs, disease-modifying antirheumatic
drugs, nonopioid analgesics, & drugs used in gout
Section VII: Endocrine drugs
Chapter 37: Hypothalamic & pituitary hormones
Chapter 38: Thyroid & antithyroid drugs
Chapter 39: Adrenocorticosteroids & adrenocortical antagonists
Chapter 40: The Gonadal hormones & inhibitors
Chapter 41: Pancreatic hormones & antidiabetic drugs
Chapter 42: Agents that affect bone mineral homeostasis
Section VIII: Chemotherapeutic drugs
Chapter 43: Beta-lactam & other cell wall- & membrane-active antibiotics
Chapter 44: Tetracyclines, macrolides, clindamycin, chloramphenicol, streptogramins, &
oxazolidinones
Chapter 45: Aminoglycosides & spectinomycin
Chapter 46: Sulfonamides, trimethoprim, & quinolones
Chapter 47: Antimycobacterial drugs
Chapter 48: Antifungal agents
Chapter 49: Antiviral agents
Chapter 50: Miscellaneous antimicrobial agents; disinfectants, antiseptics, & sterilants
Chapter 51: Clinical use of antimicrobial agents
Chapter 52: Antiprotozoal drugs
Chapter 53: Clinical pharmacology of the antihelminthic drugs
Chapter 54: Cancer chemotherapy
Chapter 55: Immunopharmacology
Section IX: Toxicology
Chapter 56: Introduction to toxicology: occupational & environmental
Chapter 57: Heavy metal intoxication & chelators
Chapter 58: Management of the poisoned patient
Section X: Special topics
Chapter 59: Special aspects of perinatal & pediatric pharmacology
Chapter 60: Special aspects of geriatric pharmacology
Chapter 61: Dermatologic pharmacology
Chapter 62: Drugs used in the treatment of gastrointestinal diseases
Chapter 63: Therapeutic & toxic potential of over-the-counter agents
Chapter 64: Dietary supplements & herbal medications
Chapter 65: Rational prescribing & prescription writing
Chapter 66: Important drug interactions & their mechanisms
,Bertram Katzung: Basic and Clinical Pharmacology 15th Edition
Chapter 1. Introduction: The Nature of Drugs & Drug Development & Regulation
Multiple Choice
1. A nurse working in radiology administers iodine to a patient who is having a
computed tomography (CT) scan. The nurse working on the oncology unit
administers chemotherapy to patients who have cancer. At the Public Health
Department, a nurse administers a measles-mumps-rubella (MMR) vaccine to
a 14-month-old child as a routine immunization. Which branch of
pharmacology best describes the actions of all three nurses?
A) Pharmacoeconomics
B) Pharmacotherapeutics
C) Pharmacodynamics
D) Pharmacokinetics
Ans: B
Feedback:
Pharmacology is the study of the biologic effects of chemicals. Nurses are
involved with clinical pharmacology or pharmacotherapeutics, which is a
branch of pharmacology that deals with the uses of drugs to treat, prevent,
and diagnose disease. The radiology nurse is administering a drug to help
diagnose a disease. The oncology nurse is administering a drug to help treat a
disease. Pharmacoeconomics includes any costs involved in drug therapy.
Pharmacodynamics involves how a drug affects the body and
pharmacokinetics is how the body acts on the body.
2. A physician has ordered intramuscular (IM) injections of morphine, a
narcotic, every 4 hours as needed for pain in a motor vehicle accident victim.
The nurse is aware this drug has a high abuse potential. Under what category
would morphine be classified?
A) Schedule I
B) Schedule II
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,C) Schedule III
D) Schedule IV
Ans: B
Feedback:
Narcotics with a high abuse potential are classified as Schedule II drugs
because of severe dependence liability. Schedule I drugs have high abuse
potential and no accepted medical use. Schedule III drugs have a lesser
abuse potential than II and an accepted medical use. Schedule IV drugs have
low abuse potential and limited dependence liability.
3. When involved in phase III drug evaluation studies, what responsibilities
would the nurse have?
A) Working with animals who are given experimental drugs
B) Choosing appropriate patients to be involved in the drug study
C) Monitoring and observing patients closely for adverse effects
D) Conducting research to determine effectiveness of the drug
Ans: C
Feedback:
Phase III studies involve use of a drug in a vast clinical population in which
patients are asked to record any symptoms they experience while taking the
drugs. Nurses may be responsible for helping collect and analyze the
information to be shared with the Food and Drug Administration (FDA) but
would not conduct research independently because nurses do not prescribe
medications. Use of animals in drug testing is done in the preclinical trials.
Select patients who are involved in phase II studies to participate in studies
where the participants have the disease the drug is intended to treat. These
patients are monitored closely for drug action and adverse effects. Phase I
studies involve healthy human volunteers who are usually paid for their
participation. Nurses may observe for adverse effects and toxicity.
4. What concept is considered when generic drugs are substituted for brand
name drugs?
A) Bioavailability
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, B) Critical concentration
C) Distribution
D) Half-life
Ans: A
Feedback:
Bioavailability is the portion of a dose of a drug that reaches the systemic
circulation and is available to act on body cells. Binders used in a generic
drug may not be the same as those used in the brand name drug. Therefore,
the way the body breaks down and uses the drug may differ, which may
eliminate a generic drug substitution. Critical concentration is the amount of
a drug that is needed to cause a therapeutic effect and should not differ
between generic and brand name medications. Distribution is the phase of
pharmacokinetics, which involves the movement of a drug to the bodys
tissues and is the same in generic and brand name drugs. A drugs half-life is
the time it takes for the amount of drug to decrease to half the peak level,
which should not change when substituting a generic medication.
5. A nurse is assessing the patients home medication use. After listening to the
patient list current medications, the nurse asks what priority question?
A) Do you take any generic medications?
B) Are any of these medications orphan drugs?
C) Are these medications safe to take during pregnancy?
D) Do you take any over-the-counter medications?
Ans: D
Feedback:
It is important for the nurse to specifically question use of over-the-counter
medications because patients may not consider them important. The patient
is unlikely to know the meaning of orphan drugs unless they too are health
care providers. Safety during pregnancy, use of a generic medication, or
classification of orphan drugs are things the patient would be unable to
answer but could be found in reference books if the nurse wishes to research
them.
WWW.THENURSINGMASTERY.COM
Basic and Clinical Pharmacology by Bertram Katzung
15th Edition
TEST BANK
, Test Bank For Basic and Clinical Pharmacology 15th Edition by Bertram Katzung
Table of Contents:
Section I: Basic principles
Chapter 1: Introduction: the nature of drugs & drug development & regulation
Chapter 2: Drug receptors & pharmacodynamics
Chapter 3: Pharmacokinetics & pharmacodynamics: rational dosing & the time course of
drug action
Chapter 4: Drug biotransformation
Chapter 5: Pharmacogenomics
Section II: Autonomic drugs
Chapter 6: Introduction to autonomic pharmacology
Chapter 7: Cholinoceptor-activating & cholinesterase-inhibiting drugs
Chapter 8: Cholinoceptor-blocking drugs
Chapter 9: Adrenoceptor agonists & sympathomimetic drugs
Chapter 10: Adrenoceptor antagonist drugs
Section III: Cardiovascular-renal drugs
Chapter 11: Antihypertensive agents
Chapter 12: Vasodilators & the treatment of angina pectoris
Chapter 13: Drugs used in heart failure
Chapter 14: Agents used in cardiac arrhythmias
Chapter 15: Diuretic agents
Section IV: Drugs with important actions on smooth muscle
Chapter 16: Histamine, serotonin, & the ergot alkaloids
Chapter 17: Vasoactive peptides
Chapter 18: The Eicosanoids: prostaglandins, thromboxanes, leukotrienes, & related
compounds
Chapter 19: Nitric oxide
Chapter 20: Drugs used in asthma
Section V: Drugs that act in the central nervous system
Chapter 21: Introduction to the pharmacology of cns drugs
Chapter 22: Sedative-hypnotic drugs
Chapter 23: The Alcohols
Chapter 24: Antiseizure drugs
Chapter 25: General anesthetics
Chapter 26: Local anesthetics
Chapter 27: Skeletal muscle relaxants
Chapter 28: Pharmacologic management of parkinsonism & other movement disorders
Chapter 29: Antipsychotic agents & lithium
Chapter 30: Antidepressant agents
Chapter 31: Opioid agonists & antagonists
Chapter 32: Drugs of abuse
,Section VI: Drugs used to treat diseases of the blood, inflammation, & gout
Chapter 33: Agents used in cytopenias; hematopoietic growth factors
Chapter 34: Drugs used in disorders of coagulation
Chapter 35: Agents used in dyslipidemia
Chapter 36: Nonsteroidal anti-inflammatory drugs, disease-modifying antirheumatic
drugs, nonopioid analgesics, & drugs used in gout
Section VII: Endocrine drugs
Chapter 37: Hypothalamic & pituitary hormones
Chapter 38: Thyroid & antithyroid drugs
Chapter 39: Adrenocorticosteroids & adrenocortical antagonists
Chapter 40: The Gonadal hormones & inhibitors
Chapter 41: Pancreatic hormones & antidiabetic drugs
Chapter 42: Agents that affect bone mineral homeostasis
Section VIII: Chemotherapeutic drugs
Chapter 43: Beta-lactam & other cell wall- & membrane-active antibiotics
Chapter 44: Tetracyclines, macrolides, clindamycin, chloramphenicol, streptogramins, &
oxazolidinones
Chapter 45: Aminoglycosides & spectinomycin
Chapter 46: Sulfonamides, trimethoprim, & quinolones
Chapter 47: Antimycobacterial drugs
Chapter 48: Antifungal agents
Chapter 49: Antiviral agents
Chapter 50: Miscellaneous antimicrobial agents; disinfectants, antiseptics, & sterilants
Chapter 51: Clinical use of antimicrobial agents
Chapter 52: Antiprotozoal drugs
Chapter 53: Clinical pharmacology of the antihelminthic drugs
Chapter 54: Cancer chemotherapy
Chapter 55: Immunopharmacology
Section IX: Toxicology
Chapter 56: Introduction to toxicology: occupational & environmental
Chapter 57: Heavy metal intoxication & chelators
Chapter 58: Management of the poisoned patient
Section X: Special topics
Chapter 59: Special aspects of perinatal & pediatric pharmacology
Chapter 60: Special aspects of geriatric pharmacology
Chapter 61: Dermatologic pharmacology
Chapter 62: Drugs used in the treatment of gastrointestinal diseases
Chapter 63: Therapeutic & toxic potential of over-the-counter agents
Chapter 64: Dietary supplements & herbal medications
Chapter 65: Rational prescribing & prescription writing
Chapter 66: Important drug interactions & their mechanisms
,Bertram Katzung: Basic and Clinical Pharmacology 15th Edition
Chapter 1. Introduction: The Nature of Drugs & Drug Development & Regulation
Multiple Choice
1. A nurse working in radiology administers iodine to a patient who is having a
computed tomography (CT) scan. The nurse working on the oncology unit
administers chemotherapy to patients who have cancer. At the Public Health
Department, a nurse administers a measles-mumps-rubella (MMR) vaccine to
a 14-month-old child as a routine immunization. Which branch of
pharmacology best describes the actions of all three nurses?
A) Pharmacoeconomics
B) Pharmacotherapeutics
C) Pharmacodynamics
D) Pharmacokinetics
Ans: B
Feedback:
Pharmacology is the study of the biologic effects of chemicals. Nurses are
involved with clinical pharmacology or pharmacotherapeutics, which is a
branch of pharmacology that deals with the uses of drugs to treat, prevent,
and diagnose disease. The radiology nurse is administering a drug to help
diagnose a disease. The oncology nurse is administering a drug to help treat a
disease. Pharmacoeconomics includes any costs involved in drug therapy.
Pharmacodynamics involves how a drug affects the body and
pharmacokinetics is how the body acts on the body.
2. A physician has ordered intramuscular (IM) injections of morphine, a
narcotic, every 4 hours as needed for pain in a motor vehicle accident victim.
The nurse is aware this drug has a high abuse potential. Under what category
would morphine be classified?
A) Schedule I
B) Schedule II
WWW.THENURSINGMASTERY.COM
,C) Schedule III
D) Schedule IV
Ans: B
Feedback:
Narcotics with a high abuse potential are classified as Schedule II drugs
because of severe dependence liability. Schedule I drugs have high abuse
potential and no accepted medical use. Schedule III drugs have a lesser
abuse potential than II and an accepted medical use. Schedule IV drugs have
low abuse potential and limited dependence liability.
3. When involved in phase III drug evaluation studies, what responsibilities
would the nurse have?
A) Working with animals who are given experimental drugs
B) Choosing appropriate patients to be involved in the drug study
C) Monitoring and observing patients closely for adverse effects
D) Conducting research to determine effectiveness of the drug
Ans: C
Feedback:
Phase III studies involve use of a drug in a vast clinical population in which
patients are asked to record any symptoms they experience while taking the
drugs. Nurses may be responsible for helping collect and analyze the
information to be shared with the Food and Drug Administration (FDA) but
would not conduct research independently because nurses do not prescribe
medications. Use of animals in drug testing is done in the preclinical trials.
Select patients who are involved in phase II studies to participate in studies
where the participants have the disease the drug is intended to treat. These
patients are monitored closely for drug action and adverse effects. Phase I
studies involve healthy human volunteers who are usually paid for their
participation. Nurses may observe for adverse effects and toxicity.
4. What concept is considered when generic drugs are substituted for brand
name drugs?
A) Bioavailability
WWW.THENURSINGMASTERY.COM
, B) Critical concentration
C) Distribution
D) Half-life
Ans: A
Feedback:
Bioavailability is the portion of a dose of a drug that reaches the systemic
circulation and is available to act on body cells. Binders used in a generic
drug may not be the same as those used in the brand name drug. Therefore,
the way the body breaks down and uses the drug may differ, which may
eliminate a generic drug substitution. Critical concentration is the amount of
a drug that is needed to cause a therapeutic effect and should not differ
between generic and brand name medications. Distribution is the phase of
pharmacokinetics, which involves the movement of a drug to the bodys
tissues and is the same in generic and brand name drugs. A drugs half-life is
the time it takes for the amount of drug to decrease to half the peak level,
which should not change when substituting a generic medication.
5. A nurse is assessing the patients home medication use. After listening to the
patient list current medications, the nurse asks what priority question?
A) Do you take any generic medications?
B) Are any of these medications orphan drugs?
C) Are these medications safe to take during pregnancy?
D) Do you take any over-the-counter medications?
Ans: D
Feedback:
It is important for the nurse to specifically question use of over-the-counter
medications because patients may not consider them important. The patient
is unlikely to know the meaning of orphan drugs unless they too are health
care providers. Safety during pregnancy, use of a generic medication, or
classification of orphan drugs are things the patient would be unable to
answer but could be found in reference books if the nurse wishes to research
them.
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