NR 565 Advanced Pharmacology Exam Study Guide with Complete Solutions

NR 565 Advanced Pharmacology Exam Study Guide with Complete Solutions During what trimester is a pregnant woman most at risk for adverse drug reactions with potential long term consequences? ANSWER 1st trimester (fetus most at risk d/t rapid growth) What is BEERS criteria? ANSWER Recommendations of medications inappropriate for elderly (65 and older), prescriber ultimately decides What is the CYP450 (cytochrome P450) ANSWER liver enzyme system where medications are metabolized, can either be inducers or inhibitors and create drug-drug interactions CYP450 inducers ANSWER Speed up metabolism of drugs (drug is cleared faster), drug has lesser effect (decrease blood levels of drug), elevate CYP450 enzymes CYP450 inducers pneumonic ANSWER "Bullshit Crap GPS INDUCES rage" CYP450 inducer drug names ANSWER Barbituates, St John wort, Carbamazepine, rifampin, alcohol, phenytoin, griseofulvin, phenobarbital, sulfonylureas CYP450 inhibitors ANSWER inhibit metabolism, increase blood levels of medications