1|Page
LMR PMHNP EXAM | CERTIFIED QUESTIONS
WITH CORRECT SOLUTIONS
Abnormalities or changes/deficits in the PFC, amygdala, basal ganglia,
hippocampus, and limbic regions of the brain can cause? - Correct-answer-
schizophrenia = aggression, impulsivity, and abstract thinking problems
What does the mesolimbic consist of? - Correct-answer-Nucleus accumbens (NA)
+ Ventral tegmental are (VTA)
What does the Mesocorticol pathway consist of? - Correct-answer-Ventral
tegmental area (VTA) connects to the cortex of the brain.
What does the Nigrostriatal pathway consist of - Correct-answer-Substantia nigra
+ striatum
,2|Page
. What happens when meds are used to decrease dopamine in mesolimbic and
mesocortical pathways? - Correct-answer-We decrease dopamine in the
Nigrostriatal causing PARKINSONISM
What happens in the mesocortical system if there is decreased dopamine? -
Correct-answer--It causes negative symptoms in schizophrenic symptoms.
-Decreased pleasure, facial expressions, they are not happy!
What happens in the mesolimbic pathway if there is too much dopamine? -
Correct-answer-This causes positive schizophrenia symptoms like DELUSIONS +
HALLUCINATIONS
What does the tuberoinfundibular pathway consist of? - Correct-answer-It
consists of the pituitary gland
What happens in the tuberoinfundibular pathway when dopamin increases and
decreases? - Correct-answer--When dopamine increases it will decrease prolactin.
-When dopamine decreases it will increase prolactin resulting in galactorrhea
,3|Page
What does NMS do to the muscles and what is this called? - Correct-answer-
Rhabdomyolysis ( Muscle break down)
What electrolyte is elevated in NMS? - Correct-answer-Potassium
How is psychosis treated? - Correct-answer-By reducing dopamine in the
mesolimbic pathway
What happens when antipsychotics block Histamine-1 receptors? - Correct-
answer-Weight gain and sedation
What happens when the muscarinic -1 receptor is blocked by antipsychotic? -
Correct-answer-Dry mouth +visual changes
What is the biggest risk for 1st gen antipsychotics? - Correct-answer-EPS
(extrapyramidal symptoms +NMS neuroleptic malignant syndrome
, 4|Page
What are 2nd generation antipsychotics? - Correct-answer-Risperdal
Olanzapine
Ziprasidone
Lurasidone
Clozapine
Quetiapine
Aripiprazole (least sedating)
124. What receptors do 2nd gen antipsychotic meds block ? - Correct-answer-D2
+ 5HT2A inhibition
What lab to test when starting a 2nd gen antipsychotic? - Correct-answer-CBC
What are the highest risks while on 2nd gen antipsychotics? - Correct-answer--
Weight gain (way more than 1st gen)
-Hyperprolactinemia
-Agranulocytosis
LMR PMHNP EXAM | CERTIFIED QUESTIONS
WITH CORRECT SOLUTIONS
Abnormalities or changes/deficits in the PFC, amygdala, basal ganglia,
hippocampus, and limbic regions of the brain can cause? - Correct-answer-
schizophrenia = aggression, impulsivity, and abstract thinking problems
What does the mesolimbic consist of? - Correct-answer-Nucleus accumbens (NA)
+ Ventral tegmental are (VTA)
What does the Mesocorticol pathway consist of? - Correct-answer-Ventral
tegmental area (VTA) connects to the cortex of the brain.
What does the Nigrostriatal pathway consist of - Correct-answer-Substantia nigra
+ striatum
,2|Page
. What happens when meds are used to decrease dopamine in mesolimbic and
mesocortical pathways? - Correct-answer-We decrease dopamine in the
Nigrostriatal causing PARKINSONISM
What happens in the mesocortical system if there is decreased dopamine? -
Correct-answer--It causes negative symptoms in schizophrenic symptoms.
-Decreased pleasure, facial expressions, they are not happy!
What happens in the mesolimbic pathway if there is too much dopamine? -
Correct-answer-This causes positive schizophrenia symptoms like DELUSIONS +
HALLUCINATIONS
What does the tuberoinfundibular pathway consist of? - Correct-answer-It
consists of the pituitary gland
What happens in the tuberoinfundibular pathway when dopamin increases and
decreases? - Correct-answer--When dopamine increases it will decrease prolactin.
-When dopamine decreases it will increase prolactin resulting in galactorrhea
,3|Page
What does NMS do to the muscles and what is this called? - Correct-answer-
Rhabdomyolysis ( Muscle break down)
What electrolyte is elevated in NMS? - Correct-answer-Potassium
How is psychosis treated? - Correct-answer-By reducing dopamine in the
mesolimbic pathway
What happens when antipsychotics block Histamine-1 receptors? - Correct-
answer-Weight gain and sedation
What happens when the muscarinic -1 receptor is blocked by antipsychotic? -
Correct-answer-Dry mouth +visual changes
What is the biggest risk for 1st gen antipsychotics? - Correct-answer-EPS
(extrapyramidal symptoms +NMS neuroleptic malignant syndrome
, 4|Page
What are 2nd generation antipsychotics? - Correct-answer-Risperdal
Olanzapine
Ziprasidone
Lurasidone
Clozapine
Quetiapine
Aripiprazole (least sedating)
124. What receptors do 2nd gen antipsychotic meds block ? - Correct-answer-D2
+ 5HT2A inhibition
What lab to test when starting a 2nd gen antipsychotic? - Correct-answer-CBC
What are the highest risks while on 2nd gen antipsychotics? - Correct-answer--
Weight gain (way more than 1st gen)
-Hyperprolactinemia
-Agranulocytosis
