TEST BANK
Cellular and Molecular Immunology
Abul Abbas, Andrew Lichtman, and Shiv Pillai
10th Edition
PlusBay.Plus
,Table80of80Contents
Chapter800180Properties80and80Overview80of80Immune80Responses 1
Chapter800280Cells80and80Tissues80of80the80Immune80System 3
Chapter800380Leukocyte80Circulation80and80Migration80Into80Tissues 6
Chapter800480Innate80Immunity 10
Chapter800580Antibodies80and80Antigens 17
Chapter800680Antigen80Presentation80to80T80Lymphocytes80and80the80Functions80of80Major
Histocompatibility80Complex80Molecules 20
Chapter800780Immune80Receptors80and80Signal80Transduction 27
Chapter800880Lymphocyte80Development80and80Antigen80Receptor80Gene80Rearrangement 30
Chapter800980Activation80of80T80Lymphocytes 34
Chapter801080Differentiation80and80Functions80of80CD4+80Effector80T80Cells 38
Chapter801180Differentiation80and80Functions80of80CD8+80Effector80T80Cells 42
Chapter801280B80Cell80Activation80and80Antibody80Production 46
Chapter801380Effector80Mechanisms80of80Humoral80Immunity 52
Chapter801480Specialized80Immunity80at80Epithelial80Barriers80and80in80Immune80Privileged80Tissues 56
Chapter801580Immunologic80Tolerance80and80Autoimmunity 62
Chapter801680Immunity80to80Microbes 67
Chapter801780Transplantation80Immunology 72
Chapter801880Tumor80Immunology 77
Chapter801980Hypersensitivity80Disorders 81
Chapter802080Allergy 86
Chapter802180Primary80and80Acquired80Immunodeficiencies 89
PlusBay.Plus
,Chapter8001:80Properties80and80Overview80of80Immune80Responses
Abbas,80Lichtman,80and80Pillai:80Cellular80and80Molecular80Immunology,8010th80Edition
MULTIPLE80CHOICE
1. The80principal80function80of80the80immune80system80is:
a. Defense80against80cancer
b. Repair80of80injured80tissues
c. Defense80against80microbial80infections
d. Prevention80of80inflammatory80diseases
e. Protection80against80environmental80toxins
ANS:8 0 8 0 C
The80immune80system80has80evolved80in80the80setting80of80selective80pressures80imposed80by80
microbial80infections.80Although80immune80responses80to80cancer80may80occur,80the80concept8
0that80“immunosurveillance”80against80cancer80is80a80principal80function80of80the80immune80sy
stem80is80controversial.80Repair80of80injured80tissues80may80be80a80secondary80consequence80o
f80the80immune80responses80and80inflammation.80Although80the80immune80system80has80regul
atory80features80that80are80needed80to80prevent80excessive80inflammation,80prevention80of80infl
ammatory80diseases80is80not80a80primary80function.80The80immune80system80can80protect80agai
nst80microbial80toxins,80but80it80generally80does80not80offer80protection80against80toxins80of80n
onbiologic80origin.
2. Which80of80the80following80infectious80diseases80was80prevented80by80the80first8
0successful80vaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS:8 0 8 0 C
In801798,80Edward80Jenner80reported80the80first80intentional80successful80vaccination,80whi
ch80was80against80smallpox80in80a80boy,80using80material80from80the80cowpox80pustules80of8
0a80milkmaid.80In801980,80smallpox80was80reported80to80be80eradicated80worldwide80by80a80
vaccination80program.80Effective80vaccines80against80tetanus80toxin,80rubella80virus,80and80
poliovirus80were80developed80in80the8020th80century80and80are80widely80used.80There80is80n
o80effective80vaccine80against80Mycobacterium80tuberculosis.
3. Which80of80the80following80is80a80unique80property80of80the80adaptive80immune80system?
a. Highly80diverse80repertoire80of80specificities80for80antigens
b. Self-nonself80 discrimination
c. Recognition80of80microbial80structures80by80both80cell-associated80and80soluble80receptors
d. Protection80against80viral80infections
e. Responses80that80have80the80same80kinetics80and80magnitude80on80repeated80expo
sure80to80the80same80microbe
ANS:8 0 8 0 A
PlusBay.Plus
, Highly80diverse80repertoires80of80specificities80for80antigens80are80found80only80in80T80and8
0B80lymphocytes,80which80are80the80central80cellular80components80of80the80adaptive80imm
une80system.80Both80the80innate80and80the80adaptive80immune80systems80use80cell-
associated80and80soluble80receptors80to80recognize80microbes,80display80some80degree80of80
self-
nonself80discrimination,80and80protect80against80viruses.80On80repeated80exposure80to80the80
same80microbe,80the80adaptive80immune80response80becomes80more80rapid80and80of80greate
r80magnitude;80this80is80the80manifestation80of80memory.
4. Antibodies80and80T80lymphocytes80are80the80respective80mediators80of80which80tw
o80types80of80immunity?
a. Innate80and80adaptive
b. Passive80and80active
c. Specific80and80nonspecific
d. Humoral80and80cell-mediated
e. Adult80and80neonatal
ANS:8 0 8 0 D
Both80B80and80T80lymphocytes80are80principal80components80of80adaptive80immunity.80B80l
ymphocytes80produce80antibodies,80which80are80the80recognition80and80effector80molecules8
0of80humoral80immune80responses80to80extracellular80pathogens.80T80cells80recognize80and80
promote80eradication80of80intracellular80pathogens80in80cell-
mediated80immunity.80Passive80and80active80immunity80both80can80be80mediated80by80either8
0B80or80T80lymphocytes.80Specific80immunity80is80another80term80for80adaptive80immunity.80
Both80B80and80T80lymphocytes80participate80in80adult80adaptive80immunity80but80are80still80
developing80in80the80neonatal80period.
5. The80two80major80functional80classes80of80effector80T80lymphocytes80are:
a. Helper80T80lymphocytes80and80cytotoxic80T80lymphocytes
b. Natural80killer80cells80and80cytoWtoWxW
ic.TTlBSM
ymph.oW
cyStes
c. Memory80T80cells80and80effector80T80cells
d. Helper80cells80and80antigen-presenting80cells
e. Cytotoxic80T80lymphocytes80and80target80cells
ANS:8 0 8 0 A
T80cells80can80be80classified80into80effector80subsets80that80perform80different80effector80fun
ctions.80Most80effector80T80cells80are80either80helper80T80lymphocytes,80which80enhance80th
e80responses80of80other80immune80cells,80including80phagocytes80and80B80cells,80to80infecti
ons,80or80cytotoxic80T80lymphocytes,80which80directly80kill80infected80cells.80Natural80killer
80cells80are80not80T80lymphocytes.
Antigen-
presenting80cells80usually80are80not80T80cells.80Memory80T80cells80are80not80effector80T80cells.
6. Which80of80the80following80cell80types80is80required80for80all80adaptive80humoral80immune80res
ponses?
a. Natural80killer80cells
b. Dendritic80cells
c. Cytolytic80T80lymphocytes
d. B80lymphocytes
e. Helper80T80lymphocytes
ANS:8 0 8 0 D
Humoral80immune80responses80are80antibody-
mediated80immune80responses,80and80all80antibodies80are80made80by80B80lymphocytes80and
PlusBay.Plus
Cellular and Molecular Immunology
Abul Abbas, Andrew Lichtman, and Shiv Pillai
10th Edition
PlusBay.Plus
,Table80of80Contents
Chapter800180Properties80and80Overview80of80Immune80Responses 1
Chapter800280Cells80and80Tissues80of80the80Immune80System 3
Chapter800380Leukocyte80Circulation80and80Migration80Into80Tissues 6
Chapter800480Innate80Immunity 10
Chapter800580Antibodies80and80Antigens 17
Chapter800680Antigen80Presentation80to80T80Lymphocytes80and80the80Functions80of80Major
Histocompatibility80Complex80Molecules 20
Chapter800780Immune80Receptors80and80Signal80Transduction 27
Chapter800880Lymphocyte80Development80and80Antigen80Receptor80Gene80Rearrangement 30
Chapter800980Activation80of80T80Lymphocytes 34
Chapter801080Differentiation80and80Functions80of80CD4+80Effector80T80Cells 38
Chapter801180Differentiation80and80Functions80of80CD8+80Effector80T80Cells 42
Chapter801280B80Cell80Activation80and80Antibody80Production 46
Chapter801380Effector80Mechanisms80of80Humoral80Immunity 52
Chapter801480Specialized80Immunity80at80Epithelial80Barriers80and80in80Immune80Privileged80Tissues 56
Chapter801580Immunologic80Tolerance80and80Autoimmunity 62
Chapter801680Immunity80to80Microbes 67
Chapter801780Transplantation80Immunology 72
Chapter801880Tumor80Immunology 77
Chapter801980Hypersensitivity80Disorders 81
Chapter802080Allergy 86
Chapter802180Primary80and80Acquired80Immunodeficiencies 89
PlusBay.Plus
,Chapter8001:80Properties80and80Overview80of80Immune80Responses
Abbas,80Lichtman,80and80Pillai:80Cellular80and80Molecular80Immunology,8010th80Edition
MULTIPLE80CHOICE
1. The80principal80function80of80the80immune80system80is:
a. Defense80against80cancer
b. Repair80of80injured80tissues
c. Defense80against80microbial80infections
d. Prevention80of80inflammatory80diseases
e. Protection80against80environmental80toxins
ANS:8 0 8 0 C
The80immune80system80has80evolved80in80the80setting80of80selective80pressures80imposed80by80
microbial80infections.80Although80immune80responses80to80cancer80may80occur,80the80concept8
0that80“immunosurveillance”80against80cancer80is80a80principal80function80of80the80immune80sy
stem80is80controversial.80Repair80of80injured80tissues80may80be80a80secondary80consequence80o
f80the80immune80responses80and80inflammation.80Although80the80immune80system80has80regul
atory80features80that80are80needed80to80prevent80excessive80inflammation,80prevention80of80infl
ammatory80diseases80is80not80a80primary80function.80The80immune80system80can80protect80agai
nst80microbial80toxins,80but80it80generally80does80not80offer80protection80against80toxins80of80n
onbiologic80origin.
2. Which80of80the80following80infectious80diseases80was80prevented80by80the80first8
0successful80vaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS:8 0 8 0 C
In801798,80Edward80Jenner80reported80the80first80intentional80successful80vaccination,80whi
ch80was80against80smallpox80in80a80boy,80using80material80from80the80cowpox80pustules80of8
0a80milkmaid.80In801980,80smallpox80was80reported80to80be80eradicated80worldwide80by80a80
vaccination80program.80Effective80vaccines80against80tetanus80toxin,80rubella80virus,80and80
poliovirus80were80developed80in80the8020th80century80and80are80widely80used.80There80is80n
o80effective80vaccine80against80Mycobacterium80tuberculosis.
3. Which80of80the80following80is80a80unique80property80of80the80adaptive80immune80system?
a. Highly80diverse80repertoire80of80specificities80for80antigens
b. Self-nonself80 discrimination
c. Recognition80of80microbial80structures80by80both80cell-associated80and80soluble80receptors
d. Protection80against80viral80infections
e. Responses80that80have80the80same80kinetics80and80magnitude80on80repeated80expo
sure80to80the80same80microbe
ANS:8 0 8 0 A
PlusBay.Plus
, Highly80diverse80repertoires80of80specificities80for80antigens80are80found80only80in80T80and8
0B80lymphocytes,80which80are80the80central80cellular80components80of80the80adaptive80imm
une80system.80Both80the80innate80and80the80adaptive80immune80systems80use80cell-
associated80and80soluble80receptors80to80recognize80microbes,80display80some80degree80of80
self-
nonself80discrimination,80and80protect80against80viruses.80On80repeated80exposure80to80the80
same80microbe,80the80adaptive80immune80response80becomes80more80rapid80and80of80greate
r80magnitude;80this80is80the80manifestation80of80memory.
4. Antibodies80and80T80lymphocytes80are80the80respective80mediators80of80which80tw
o80types80of80immunity?
a. Innate80and80adaptive
b. Passive80and80active
c. Specific80and80nonspecific
d. Humoral80and80cell-mediated
e. Adult80and80neonatal
ANS:8 0 8 0 D
Both80B80and80T80lymphocytes80are80principal80components80of80adaptive80immunity.80B80l
ymphocytes80produce80antibodies,80which80are80the80recognition80and80effector80molecules8
0of80humoral80immune80responses80to80extracellular80pathogens.80T80cells80recognize80and80
promote80eradication80of80intracellular80pathogens80in80cell-
mediated80immunity.80Passive80and80active80immunity80both80can80be80mediated80by80either8
0B80or80T80lymphocytes.80Specific80immunity80is80another80term80for80adaptive80immunity.80
Both80B80and80T80lymphocytes80participate80in80adult80adaptive80immunity80but80are80still80
developing80in80the80neonatal80period.
5. The80two80major80functional80classes80of80effector80T80lymphocytes80are:
a. Helper80T80lymphocytes80and80cytotoxic80T80lymphocytes
b. Natural80killer80cells80and80cytoWtoWxW
ic.TTlBSM
ymph.oW
cyStes
c. Memory80T80cells80and80effector80T80cells
d. Helper80cells80and80antigen-presenting80cells
e. Cytotoxic80T80lymphocytes80and80target80cells
ANS:8 0 8 0 A
T80cells80can80be80classified80into80effector80subsets80that80perform80different80effector80fun
ctions.80Most80effector80T80cells80are80either80helper80T80lymphocytes,80which80enhance80th
e80responses80of80other80immune80cells,80including80phagocytes80and80B80cells,80to80infecti
ons,80or80cytotoxic80T80lymphocytes,80which80directly80kill80infected80cells.80Natural80killer
80cells80are80not80T80lymphocytes.
Antigen-
presenting80cells80usually80are80not80T80cells.80Memory80T80cells80are80not80effector80T80cells.
6. Which80of80the80following80cell80types80is80required80for80all80adaptive80humoral80immune80res
ponses?
a. Natural80killer80cells
b. Dendritic80cells
c. Cytolytic80T80lymphocytes
d. B80lymphocytes
e. Helper80T80lymphocytes
ANS:8 0 8 0 D
Humoral80immune80responses80are80antibody-
mediated80immune80responses,80and80all80antibodies80are80made80by80B80lymphocytes80and
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