Clinical Medicine III – Psoriatic and Reactive
Arthritis, Exam Questions and Answers
1. what is psoriatic arthritis?: inflammatory arthritis associated
with psoriasis
(skin symptoms usually precede joint symptoms)
2. what gene is associated with psoriatic arthritis?: HLA-B27
3. what comorbidities are associated with psoriatic arthritis?:
cardiovascular disease, metabolic syndrome, DM,
depression/anxiety
4. what are clinical manifestations of psoriatic arthritis?: -
small joints of hands most commonly involved (DIPs)
-morning stiffness lasts > 30 mins
-extra articular manifestations (ocular inflammation, oral
ulcerations)
5. what are the 5 clinical domains of psoriatic arthritis?: -
peripheral arthritis
-axial disease (spondylitis, sacroiliitis)
, -enthesitis (achilles and plantar fascia MC)
-dactylitis
-skin and nail disease
6. what are the 5 presentations of psoriasis?: plaque psoriasis
(MC), guttate, inverse, pustular, erythrodermic
7. what is arthritis mutilans?: destruction of the IP joints with
marked osteolysis, resulting in "pencil in cup" appearance on xray
8. sacroiliitis in psoriatic arthritis: -may produce
erosions/sclerosis
-may produce widening of SI joints
-usually unilateral
-presents with pain and stiffness in lower back/buttocks
9. what are the most common site for skin involvement of
psoriatic arthritis?-
: elbows, knees, behind ear, scalp line, umbilicus, gluteal cleft
10. is there periarticular osteopenia on xray with psoriatic
arthritis?: no (unlike in RA... helps differentiate)
Arthritis, Exam Questions and Answers
1. what is psoriatic arthritis?: inflammatory arthritis associated
with psoriasis
(skin symptoms usually precede joint symptoms)
2. what gene is associated with psoriatic arthritis?: HLA-B27
3. what comorbidities are associated with psoriatic arthritis?:
cardiovascular disease, metabolic syndrome, DM,
depression/anxiety
4. what are clinical manifestations of psoriatic arthritis?: -
small joints of hands most commonly involved (DIPs)
-morning stiffness lasts > 30 mins
-extra articular manifestations (ocular inflammation, oral
ulcerations)
5. what are the 5 clinical domains of psoriatic arthritis?: -
peripheral arthritis
-axial disease (spondylitis, sacroiliitis)
, -enthesitis (achilles and plantar fascia MC)
-dactylitis
-skin and nail disease
6. what are the 5 presentations of psoriasis?: plaque psoriasis
(MC), guttate, inverse, pustular, erythrodermic
7. what is arthritis mutilans?: destruction of the IP joints with
marked osteolysis, resulting in "pencil in cup" appearance on xray
8. sacroiliitis in psoriatic arthritis: -may produce
erosions/sclerosis
-may produce widening of SI joints
-usually unilateral
-presents with pain and stiffness in lower back/buttocks
9. what are the most common site for skin involvement of
psoriatic arthritis?-
: elbows, knees, behind ear, scalp line, umbilicus, gluteal cleft
10. is there periarticular osteopenia on xray with psoriatic
arthritis?: no (unlike in RA... helps differentiate)
