UWorld Exam Musculoskeletal Medicine
Questions and Answers, 2025 – Comprehensive
Study Guide for MSK Disorders and Treatments
1. What 2 medications have the highest risk of causing drug-
induced lu-
pus erythematosus, which is characterized by the
development of lupus-like symptoms, in addition to positive
antinuclear and antihistone antibodies: pro- cainamide and
hydralazine
2. The most notable adverse effects of _ include thyroid
dysfunction, lung fibrosis, and liver toxicity, as well as a blue
or gray discoloration of the skin: amiodarone
3. Fever + multiple joint pains + well-demarcated rash: SLE
4. The most notable adverse effects of _ include thyroid
dysfunction, lung fibrosis, and liver toxicity, as well as a blue
or gray discoloration of the skin.: amiodarone
5. Absent foot plantar flexion in response to calf squeeze is
consistent with?-
: achilles tendon rupture
6. Results in an impaired ability to walk on the tips of the
toes: achilles tendon rupture
,7. With the elbow held in extension, passive flexion of the wrist
reproduces the patient's pain: lateral epicondylitis
8. Symptoms are chronic and associated with activities such
as climbing stairs or squatting; the pain is typically
reproducible with isometric quadri- ceps contraction:
patellofemoral pain syndrome
9. A common cause of anterior knee pain, especially in
women: patellofemoral pain syndrome
10. The patella rides low, with a palpable defect above the
patella: quadriceps tendon rupture
11. Symptoms include an audible pop, rapid swelling, and the
inability to actively extend the knee against gravity:
quadriceps tendon rupture
12. Typically seen in patients age >50 with bilateral,
symmetric proximal muscle stiffness and pain that are worse
in the mornings. Laboratory find-
ings include elevated erythrocyte sedimentation rate and C-
reactive protein: -
polymyalgia rheumatica
13. Tx polymyalgia rheumatica: steroids
14. Bisphosphonates (eg, alendronate, risedronate) are the
preferred antire- sorptive agents for most patients. Selective
estrogen receptor modulators (eg, raloxifene) are considered
,for those who cannot take bisphosphonates or for women
with increased risk of breast cancer. However, patients first
need an estimate of fracture risk to determine if any specific
treatment is needed.:
15. Antiresorptive therapy is recommended for patients with:
Osteoporosis on DXA (T-score 2.5)
Low trauma hip or vertebral fracture
Osteopenia (T-score between 1 and 2.5) and a 10-year
probability of hip fracture 3% or major osteoporotic fracture
20%:
16. On examination, the arm is held in adduction and internal
rotation: posterior shoulder dislocation
17. Osteomyelitis is a bacterial infection of the bone that
typically presents with fever and focal bony pain. Infection is
most often caused by hematoge- nous spread of?: s. aureus
18. Episodic bilateral leg pains that occur at night in children
with no as- sociated systemic symptoms, activity limitations,
or abnormal examination findings.The diagnosis is clinical,
and management includes reassurance and supportive care:
growing pains (idiopathic nocturnal pains of childhood)
19. Progressive bilateral buttock pain that radiates to the
thighs and calves. The pain is worse with standing but
, improves with leaning on a cane or sitting.: lumbar spinal
stenosis
20. Clavicle fracture can injure the underlying brachial plexus
and subclavian artery. Hard signs of arterial injury (eg, absent
pulses, distal ischemia) require immediate surgical
intervention. "Soft signs" of vascular injury (eg, unex-
plained hypotension, stable hematoma, reduced pulse)
requires _ for further evaluation.: CT angiography
21. On x-ray, it typically presents as an ill-defined sclerotic
bone lesion with a sunburst periosteal reaction in the long
bone metaphyses.: osteoosarcoma
22. Tx SCFE: surgical stabilization with screw fixation
23. Anticentromere antibodies are found in about 40% of
patients: CREST
syndrome (limited sclerosis)
24. Calcinosis, Raynaud phenomenon, Esophageal
dysmotility, Sclerodactyly, and Telangiectasias: CREST
syndrome (limited sclerosis)
25. Anti-topoisomerase I (Anti-Scl-70) antibodies are highly
specific for?: sys- temic sclerosis
26. Antihistone antibodies are found in?: drug-induced lupus
Questions and Answers, 2025 – Comprehensive
Study Guide for MSK Disorders and Treatments
1. What 2 medications have the highest risk of causing drug-
induced lu-
pus erythematosus, which is characterized by the
development of lupus-like symptoms, in addition to positive
antinuclear and antihistone antibodies: pro- cainamide and
hydralazine
2. The most notable adverse effects of _ include thyroid
dysfunction, lung fibrosis, and liver toxicity, as well as a blue
or gray discoloration of the skin: amiodarone
3. Fever + multiple joint pains + well-demarcated rash: SLE
4. The most notable adverse effects of _ include thyroid
dysfunction, lung fibrosis, and liver toxicity, as well as a blue
or gray discoloration of the skin.: amiodarone
5. Absent foot plantar flexion in response to calf squeeze is
consistent with?-
: achilles tendon rupture
6. Results in an impaired ability to walk on the tips of the
toes: achilles tendon rupture
,7. With the elbow held in extension, passive flexion of the wrist
reproduces the patient's pain: lateral epicondylitis
8. Symptoms are chronic and associated with activities such
as climbing stairs or squatting; the pain is typically
reproducible with isometric quadri- ceps contraction:
patellofemoral pain syndrome
9. A common cause of anterior knee pain, especially in
women: patellofemoral pain syndrome
10. The patella rides low, with a palpable defect above the
patella: quadriceps tendon rupture
11. Symptoms include an audible pop, rapid swelling, and the
inability to actively extend the knee against gravity:
quadriceps tendon rupture
12. Typically seen in patients age >50 with bilateral,
symmetric proximal muscle stiffness and pain that are worse
in the mornings. Laboratory find-
ings include elevated erythrocyte sedimentation rate and C-
reactive protein: -
polymyalgia rheumatica
13. Tx polymyalgia rheumatica: steroids
14. Bisphosphonates (eg, alendronate, risedronate) are the
preferred antire- sorptive agents for most patients. Selective
estrogen receptor modulators (eg, raloxifene) are considered
,for those who cannot take bisphosphonates or for women
with increased risk of breast cancer. However, patients first
need an estimate of fracture risk to determine if any specific
treatment is needed.:
15. Antiresorptive therapy is recommended for patients with:
Osteoporosis on DXA (T-score 2.5)
Low trauma hip or vertebral fracture
Osteopenia (T-score between 1 and 2.5) and a 10-year
probability of hip fracture 3% or major osteoporotic fracture
20%:
16. On examination, the arm is held in adduction and internal
rotation: posterior shoulder dislocation
17. Osteomyelitis is a bacterial infection of the bone that
typically presents with fever and focal bony pain. Infection is
most often caused by hematoge- nous spread of?: s. aureus
18. Episodic bilateral leg pains that occur at night in children
with no as- sociated systemic symptoms, activity limitations,
or abnormal examination findings.The diagnosis is clinical,
and management includes reassurance and supportive care:
growing pains (idiopathic nocturnal pains of childhood)
19. Progressive bilateral buttock pain that radiates to the
thighs and calves. The pain is worse with standing but
, improves with leaning on a cane or sitting.: lumbar spinal
stenosis
20. Clavicle fracture can injure the underlying brachial plexus
and subclavian artery. Hard signs of arterial injury (eg, absent
pulses, distal ischemia) require immediate surgical
intervention. "Soft signs" of vascular injury (eg, unex-
plained hypotension, stable hematoma, reduced pulse)
requires _ for further evaluation.: CT angiography
21. On x-ray, it typically presents as an ill-defined sclerotic
bone lesion with a sunburst periosteal reaction in the long
bone metaphyses.: osteoosarcoma
22. Tx SCFE: surgical stabilization with screw fixation
23. Anticentromere antibodies are found in about 40% of
patients: CREST
syndrome (limited sclerosis)
24. Calcinosis, Raynaud phenomenon, Esophageal
dysmotility, Sclerodactyly, and Telangiectasias: CREST
syndrome (limited sclerosis)
25. Anti-topoisomerase I (Anti-Scl-70) antibodies are highly
specific for?: sys- temic sclerosis
26. Antihistone antibodies are found in?: drug-induced lupus
