alpha 1 receptors are found in ----causing----- - ✔✔✔smooth muscle /vasoconstriction
While alpha 1 receptors cause vasoconstriction it can also cause ------ where? - ✔✔✔relaxation/GI
smooth muscle
Beta 1 receptors are found - ✔✔✔The heart
When beta 1 receptors are stimulated, 3 things happen.... - ✔✔✔1). Increase in force of contraction
2. increase in heart rate
3). increase in conduction
Beta 3 receptors decreases - ✔✔✔urinary frequency of bladder contractions which increases filling
phase of bladder
Beta 2 receptors - ✔✔✔bronchodilation in lungs
Some beta 2 receptor drugs - ✔✔✔-terol drugs like albuterol, ephedrine, terbutaline
Nasal Decongestants - ✔✔✔alpha 1 receptors
Nasal Decongestant drugs - ✔✔✔ephedrine, tetrahydrozoline, naphazoline
Ophthalmics stimulate ---- causing----- - ✔✔✔alpha receptors /arteriole vasoncontriction
Adrenergics in eyes can treat - ✔✔✔open angle glaucoma
adrenergics in the eyes can reduce - ✔✔✔intraocular pressur e
,Adrenergics in the eyes can dilate the eyes by stimulating ---- and ---- receptors - ✔✔✔alpha/beta 2
adverse for alpha receptor drugs - ✔✔✔headache, insomnia, euphoria, hypertension, reflexive
bradycardia
adverse for beta receptor drugs - ✔✔✔headache, dizziness, dysrhythmias and fluctuations in BP
toxic effects of adrenergic drugs (2 most life threatening) and ---- - ✔✔✔CNS/Cardiovascular systems
/seizures
adrenergic drugs have very short ---- - ✔✔✔half lives
Since adrenergic drugs have short half lives, if overdosed what can be done to fix the situation? -
✔✔✔Stopping the drug
Dobutamine - ✔✔✔beta 1 agonist
-inotropic agent, inc. contractility and CO, does NOT inc HR.
-used in acute management of heart failure
Dopamine - ✔✔✔beta 1 and alpha 1
dopamine at low doses - ✔✔✔dilate blood vessels in the brain and kidneys
dopamine at higher doses - ✔✔✔heart contractility and CO
dopamine at highest doses - ✔✔✔alpha 1 / vasoconstriction
dopamine is contraindicated in patients who have - ✔✔✔pheochromocytoma
, Epinephrine acts on both the ---- and ----- - ✔✔✔alpha and beta receptors
epinephrine is a ------ adrenergic agonist - ✔✔✔nonselective
epinephrine at low doses stimulates -----receptors and increases ---- of -----and ----- - ✔✔✔beta 1/force
of contraction/heart rate
epinephrine is also a ------treating anaphylactic shock - ✔✔✔bronchodilator
epinephrine has broncodilatory effects on the ---- receptors - ✔✔✔beta 2
epinephrine at high doses acts as a -----elevating-----and acts on ----- receptors -
✔✔✔vasoconstrictor/blood pressure /alpha
Fenoldapam is a peripheral ---- agonist lowering---- - ✔✔✔dopamine 1 (D1) /blood pressure
Fenoldopam also increases ------ - ✔✔✔renal flow
Midodrine acts on ---- receptors - ✔✔✔alpha 1
Midodrine treats ----- - ✔✔✔orthostatic hypotension
Midodrine is a peripheral ------ - ✔✔✔vasoconstrictor
Mirabegron is a ----- agonist - ✔✔✔Beta 3
Mirabegron - ✔✔✔Urinary Bladder Modifier