2024-
2025
Verloskunde
PROF DR VAN CALSTEREN
,Introductiecollege .................................................................................................................... 12
Inleiding en epidemiologie ................................................................................................... 12
Maternele mortaliteit....................................................................................................... 12
Morbiditeit ....................................................................................................................... 12
Perinatale mortaliteit ....................................................................................................... 13
Wat is verloskunde ............................................................................................................... 13
Lessen ................................................................................................................................... 13
Basisprincipes prenatale opvolging: module 3 .................................................................... 14
Doel prenatale zorg .......................................................................................................... 14
Preconceptie..................................................................................................................... 14
Intake raadpleging ............................................................................................................ 14
Zwangerschapscontrole ................................................................................................... 14
Voorbereiding module 2: ZG-fysiologie en klinische implicaties ......................................... 14
Prenatale screening en diagnose ............................................................................................ 15
Congenitale aandoeningen .................................................................................................. 15
Preventie .......................................................................................................................... 15
Primaire preventie........................................................................................................ 15
Secundaire preventive.................................................................................................. 16
Tertiaire preventie........................................................................................................ 16
Aanpak screening ................................................................................................................. 16
Alloimmunisatie ............................................................................................................... 16
Basisprincipes screeningstesten....................................................................................... 16
Informed consent ......................................................................................................... 16
NIPT .................................................................................................................................. 16
CMV .................................................................................................................................. 17
Prenatale echo en moderne genetica .................................................................................. 17
Echo .................................................................................................................................. 17
Prenatale diagnostische testen ........................................................................................ 18
Genetica ........................................................................................................................... 18
Zwangerschapsafbreking...................................................................................................... 19
Wetgeving ........................................................................................................................ 19
Problemen ........................................................................................................................ 19
Oorzaken .......................................................................................................................... 19
Morele dillema’s ............................................................................................................... 19
Hoe? ................................................................................................................................. 19
1
,Module 2: zwangerschap en klinische complicaties .............................................................. 19
De menstruele cyclus ........................................................................................................... 20
Ovarium ............................................................................................................................ 20
Endometrium.................................................................................................................... 20
Gametogenese ..................................................................................................................... 20
De bevruchting ..................................................................................................................... 21
De innesteling – nidatie........................................................................................................ 21
De placenta........................................................................................................................... 22
Ontwikkeling..................................................................................................................... 22
Vorm ................................................................................................................................. 23
Functie .............................................................................................................................. 24
Transport ...................................................................................................................... 24
Immunologie ................................................................................................................ 24
Metabole functie .......................................................................................................... 24
Respiratoire functie ...................................................................................................... 24
Productie ...................................................................................................................... 24
Endocriene functie ....................................................................................................... 25
Navelstreng .......................................................................................................................... 27
Vruchtzak .............................................................................................................................. 27
Vliezen .............................................................................................................................. 27
Amnionvocht .................................................................................................................... 27
De foetus .............................................................................................................................. 28
Algemene ontwikkeling .................................................................................................... 28
Foetale groei..................................................................................................................... 28
Orgaanspecifieke ontwikkeling ........................................................................................ 29
Cardiovasculaire circulatie ........................................................................................... 29
Longontwikkeling ......................................................................................................... 29
Gastro-intestinale ontwikkeling ................................................................................... 29
Urologische ontwikkeling ............................................................................................. 29
Foetale bijnier............................................................................................................... 30
Foetale schildklier......................................................................................................... 30
Foetale gonaden ........................................................................................................... 30
Foetale ZS ..................................................................................................................... 30
Foetale immuunsysteem .............................................................................................. 30
De zwangere vrouw .............................................................................................................. 30
2
, De voortplantingsorganen ............................................................................................... 30
Baarmoeder .................................................................................................................. 30
De vagina en vulva........................................................................................................ 31
Adnexen........................................................................................................................ 31
Cardiovasculair systeem ................................................................................................... 31
Hart ............................................................................................................................... 31
Perifere circulatie ......................................................................................................... 32
Kwaaltjes ...................................................................................................................... 32
Longen en ademhaling ..................................................................................................... 32
Nier en urinewegen .......................................................................................................... 33
Kwaaltjes ...................................................................................................................... 33
Hematologische veranderingen ....................................................................................... 33
Spijsvertering .................................................................................................................... 34
Immuunsysteem ............................................................................................................... 35
Muskuloskeletaal systeem ............................................................................................... 35
Huid .................................................................................................................................. 35
Endocrien en metabool systeem ...................................................................................... 36
Metabolisme ................................................................................................................ 36
Pancreas ....................................................................................................................... 36
Ovarium ........................................................................................................................ 37
Schildklier ..................................................................................................................... 37
Bijschildklier.................................................................................................................. 37
Bijnier ........................................................................................................................... 37
Hypothalamus-hypofyse .............................................................................................. 38
Gewicht ........................................................................................................................ 38
Borsten ......................................................................................................................... 38
Psychologische veranderingen ..................................................................................... 38
Module 3: Prenatale zorg ........................................................................................................ 39
Preconceptieel consult ......................................................................................................... 39
Introductie ........................................................................................................................ 39
Risico-identificatie ............................................................................................................ 39
Preconceptioneel advies .................................................................................................. 40
Advies rond stoppen met anticonceptie ...................................................................... 40
Advies mbt opstart FZ .................................................................................................. 40
Advies naar fysieke conditie, levensstijl en voeding .................................................... 40
3
2025
Verloskunde
PROF DR VAN CALSTEREN
,Introductiecollege .................................................................................................................... 12
Inleiding en epidemiologie ................................................................................................... 12
Maternele mortaliteit....................................................................................................... 12
Morbiditeit ....................................................................................................................... 12
Perinatale mortaliteit ....................................................................................................... 13
Wat is verloskunde ............................................................................................................... 13
Lessen ................................................................................................................................... 13
Basisprincipes prenatale opvolging: module 3 .................................................................... 14
Doel prenatale zorg .......................................................................................................... 14
Preconceptie..................................................................................................................... 14
Intake raadpleging ............................................................................................................ 14
Zwangerschapscontrole ................................................................................................... 14
Voorbereiding module 2: ZG-fysiologie en klinische implicaties ......................................... 14
Prenatale screening en diagnose ............................................................................................ 15
Congenitale aandoeningen .................................................................................................. 15
Preventie .......................................................................................................................... 15
Primaire preventie........................................................................................................ 15
Secundaire preventive.................................................................................................. 16
Tertiaire preventie........................................................................................................ 16
Aanpak screening ................................................................................................................. 16
Alloimmunisatie ............................................................................................................... 16
Basisprincipes screeningstesten....................................................................................... 16
Informed consent ......................................................................................................... 16
NIPT .................................................................................................................................. 16
CMV .................................................................................................................................. 17
Prenatale echo en moderne genetica .................................................................................. 17
Echo .................................................................................................................................. 17
Prenatale diagnostische testen ........................................................................................ 18
Genetica ........................................................................................................................... 18
Zwangerschapsafbreking...................................................................................................... 19
Wetgeving ........................................................................................................................ 19
Problemen ........................................................................................................................ 19
Oorzaken .......................................................................................................................... 19
Morele dillema’s ............................................................................................................... 19
Hoe? ................................................................................................................................. 19
1
,Module 2: zwangerschap en klinische complicaties .............................................................. 19
De menstruele cyclus ........................................................................................................... 20
Ovarium ............................................................................................................................ 20
Endometrium.................................................................................................................... 20
Gametogenese ..................................................................................................................... 20
De bevruchting ..................................................................................................................... 21
De innesteling – nidatie........................................................................................................ 21
De placenta........................................................................................................................... 22
Ontwikkeling..................................................................................................................... 22
Vorm ................................................................................................................................. 23
Functie .............................................................................................................................. 24
Transport ...................................................................................................................... 24
Immunologie ................................................................................................................ 24
Metabole functie .......................................................................................................... 24
Respiratoire functie ...................................................................................................... 24
Productie ...................................................................................................................... 24
Endocriene functie ....................................................................................................... 25
Navelstreng .......................................................................................................................... 27
Vruchtzak .............................................................................................................................. 27
Vliezen .............................................................................................................................. 27
Amnionvocht .................................................................................................................... 27
De foetus .............................................................................................................................. 28
Algemene ontwikkeling .................................................................................................... 28
Foetale groei..................................................................................................................... 28
Orgaanspecifieke ontwikkeling ........................................................................................ 29
Cardiovasculaire circulatie ........................................................................................... 29
Longontwikkeling ......................................................................................................... 29
Gastro-intestinale ontwikkeling ................................................................................... 29
Urologische ontwikkeling ............................................................................................. 29
Foetale bijnier............................................................................................................... 30
Foetale schildklier......................................................................................................... 30
Foetale gonaden ........................................................................................................... 30
Foetale ZS ..................................................................................................................... 30
Foetale immuunsysteem .............................................................................................. 30
De zwangere vrouw .............................................................................................................. 30
2
, De voortplantingsorganen ............................................................................................... 30
Baarmoeder .................................................................................................................. 30
De vagina en vulva........................................................................................................ 31
Adnexen........................................................................................................................ 31
Cardiovasculair systeem ................................................................................................... 31
Hart ............................................................................................................................... 31
Perifere circulatie ......................................................................................................... 32
Kwaaltjes ...................................................................................................................... 32
Longen en ademhaling ..................................................................................................... 32
Nier en urinewegen .......................................................................................................... 33
Kwaaltjes ...................................................................................................................... 33
Hematologische veranderingen ....................................................................................... 33
Spijsvertering .................................................................................................................... 34
Immuunsysteem ............................................................................................................... 35
Muskuloskeletaal systeem ............................................................................................... 35
Huid .................................................................................................................................. 35
Endocrien en metabool systeem ...................................................................................... 36
Metabolisme ................................................................................................................ 36
Pancreas ....................................................................................................................... 36
Ovarium ........................................................................................................................ 37
Schildklier ..................................................................................................................... 37
Bijschildklier.................................................................................................................. 37
Bijnier ........................................................................................................................... 37
Hypothalamus-hypofyse .............................................................................................. 38
Gewicht ........................................................................................................................ 38
Borsten ......................................................................................................................... 38
Psychologische veranderingen ..................................................................................... 38
Module 3: Prenatale zorg ........................................................................................................ 39
Preconceptieel consult ......................................................................................................... 39
Introductie ........................................................................................................................ 39
Risico-identificatie ............................................................................................................ 39
Preconceptioneel advies .................................................................................................. 40
Advies rond stoppen met anticonceptie ...................................................................... 40
Advies mbt opstart FZ .................................................................................................. 40
Advies naar fysieke conditie, levensstijl en voeding .................................................... 40
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