1. What is the hallmark of Hodgkin lymphoma?
A. Bence Jones proteins
B. Philadelphia chromosome
C. Reed-Sternberg cells
D. Myeloblast proliferation
Answer: C
Rationale: Reed-Sternberg cells are large, abnormal
lymphocytes seen in Hodgkin lymphoma.
2. In ARDS (Acute Respiratory Distress Syndrome),
what is the main pathophysiologic problem?
A. Bronchial hyperresponsiveness
B. Loss of alveolar surfactant and inflammation
C. Chronic mucus hypersecretion
D. Viral invasion of bronchial epithelium
Answer: B
Rationale: ARDS involves diffuse alveolar damage,
inflammation, and surfactant dysfunction causing
impaired gas exchange.
,3. Which of the following conditions results from a
mutation in the dystrophin gene?
A. Multiple sclerosis
B. Duchenne muscular dystrophy
C. Myasthenia gravis
D. Guillain-Barré syndrome
Answer: B
Rationale: Duchenne muscular dystrophy is caused
by a mutation in the dystrophin gene, leading to
progressive muscle weakness.
4. Which condition involves a mutation in the HFE
gene?
A. Wilson’s disease
B. Hemochromatosis
C. Cystic fibrosis
D. Alpha-1 antitrypsin deficiency
Answer: B
Rationale: Hemochromatosis is caused by HFE gene
mutations, leading to iron overload.
, 5. In anemia of chronic disease, which iron study
abnormality is most common?
A. Elevated serum iron
B. Increased total iron-binding capacity (TIBC)
C. Low ferritin
D. Low serum iron and low TIBC
Answer: D
Rationale: Anemia of chronic disease typically
presents with low serum iron and low TIBC, with
normal or elevated ferritin.
6. Hyperparathyroidism causes which of the
following lab abnormalities?
A. Low calcium
B. High phosphate
C. Low PTH
D. Hypercalcemia
Answer: D
Rationale: PTH increases calcium levels by
stimulating bone resorption and kidney reabsorption.
A. Bence Jones proteins
B. Philadelphia chromosome
C. Reed-Sternberg cells
D. Myeloblast proliferation
Answer: C
Rationale: Reed-Sternberg cells are large, abnormal
lymphocytes seen in Hodgkin lymphoma.
2. In ARDS (Acute Respiratory Distress Syndrome),
what is the main pathophysiologic problem?
A. Bronchial hyperresponsiveness
B. Loss of alveolar surfactant and inflammation
C. Chronic mucus hypersecretion
D. Viral invasion of bronchial epithelium
Answer: B
Rationale: ARDS involves diffuse alveolar damage,
inflammation, and surfactant dysfunction causing
impaired gas exchange.
,3. Which of the following conditions results from a
mutation in the dystrophin gene?
A. Multiple sclerosis
B. Duchenne muscular dystrophy
C. Myasthenia gravis
D. Guillain-Barré syndrome
Answer: B
Rationale: Duchenne muscular dystrophy is caused
by a mutation in the dystrophin gene, leading to
progressive muscle weakness.
4. Which condition involves a mutation in the HFE
gene?
A. Wilson’s disease
B. Hemochromatosis
C. Cystic fibrosis
D. Alpha-1 antitrypsin deficiency
Answer: B
Rationale: Hemochromatosis is caused by HFE gene
mutations, leading to iron overload.
, 5. In anemia of chronic disease, which iron study
abnormality is most common?
A. Elevated serum iron
B. Increased total iron-binding capacity (TIBC)
C. Low ferritin
D. Low serum iron and low TIBC
Answer: D
Rationale: Anemia of chronic disease typically
presents with low serum iron and low TIBC, with
normal or elevated ferritin.
6. Hyperparathyroidism causes which of the
following lab abnormalities?
A. Low calcium
B. High phosphate
C. Low PTH
D. Hypercalcemia
Answer: D
Rationale: PTH increases calcium levels by
stimulating bone resorption and kidney reabsorption.
