1. Which condition is characterized by destruction of
acetylcholine receptors at the neuromuscular
junction?
A. Guillain-Barré syndrome
B. Multiple sclerosis
C. Myasthenia gravis
D. ALS
Answer: C
Rationale: Myasthenia gravis is an autoimmune
disorder affecting neuromuscular transmission by
targeting ACh receptors.
2. The pathophysiology of rheumatoid arthritis
involves:
A. Non-inflammatory joint degeneration
B. Immune complex-mediated joint inflammation
C. Viral infection of the synovium
D. Cartilage trauma
Answer: B
,Rationale: RA is an autoimmune disease where
immune complexes attack synovial joints, causing
inflammation and destruction.
3. In ARDS (Acute Respiratory Distress Syndrome),
what is the main pathophysiologic problem?
A. Bronchial hyperresponsiveness
B. Loss of alveolar surfactant and inflammation
C. Chronic mucus hypersecretion
D. Viral invasion of bronchial epithelium
Answer: B
Rationale: ARDS involves diffuse alveolar damage,
inflammation, and surfactant dysfunction causing
impaired gas exchange.
4. What is the hallmark of Hodgkin lymphoma?
A. Bence Jones proteins
B. Philadelphia chromosome
C. Reed-Sternberg cells
D. Myeloblast proliferation
Answer: C
, Rationale: Reed-Sternberg cells are large, abnormal
lymphocytes seen in Hodgkin lymphoma.
5. Which of the following is most associated with
aortic dissection?
A. Hyperlipidemia
B. Marfan syndrome
C. Anemia
D. Diabetes mellitus
Answer: B
Rationale: Marfan syndrome weakens connective
tissue, predisposing to aortic dissection.
6. Which of the following is most likely in a patient
with metabolic acidosis?
A. Hypoventilation
B. Low serum bicarbonate
C. High pH
D. Decreased anion gap
Answer: B
acetylcholine receptors at the neuromuscular
junction?
A. Guillain-Barré syndrome
B. Multiple sclerosis
C. Myasthenia gravis
D. ALS
Answer: C
Rationale: Myasthenia gravis is an autoimmune
disorder affecting neuromuscular transmission by
targeting ACh receptors.
2. The pathophysiology of rheumatoid arthritis
involves:
A. Non-inflammatory joint degeneration
B. Immune complex-mediated joint inflammation
C. Viral infection of the synovium
D. Cartilage trauma
Answer: B
,Rationale: RA is an autoimmune disease where
immune complexes attack synovial joints, causing
inflammation and destruction.
3. In ARDS (Acute Respiratory Distress Syndrome),
what is the main pathophysiologic problem?
A. Bronchial hyperresponsiveness
B. Loss of alveolar surfactant and inflammation
C. Chronic mucus hypersecretion
D. Viral invasion of bronchial epithelium
Answer: B
Rationale: ARDS involves diffuse alveolar damage,
inflammation, and surfactant dysfunction causing
impaired gas exchange.
4. What is the hallmark of Hodgkin lymphoma?
A. Bence Jones proteins
B. Philadelphia chromosome
C. Reed-Sternberg cells
D. Myeloblast proliferation
Answer: C
, Rationale: Reed-Sternberg cells are large, abnormal
lymphocytes seen in Hodgkin lymphoma.
5. Which of the following is most associated with
aortic dissection?
A. Hyperlipidemia
B. Marfan syndrome
C. Anemia
D. Diabetes mellitus
Answer: B
Rationale: Marfan syndrome weakens connective
tissue, predisposing to aortic dissection.
6. Which of the following is most likely in a patient
with metabolic acidosis?
A. Hypoventilation
B. Low serum bicarbonate
C. High pH
D. Decreased anion gap
Answer: B
