, Test Bank b
to accompany
b
Psychopharmacology, Third Edition b b
Meyer • Quenzer b b
Chapter 1: Principles of Pharmacology b b b b
Multiple Choice b
1. refer(s) to specific molecular changes that occur when a drug binds to a
b b b b b b b b b b b b
particular target site or receptor, while
b b are the resulting widespread alterations
b b b b b b b b
in function.
b b
a. Drug action; therapeutic effects
b b b
b. Side effects; drug effects
b b b
c. Therapeutic effects; side effects b b b
d. Drug action; drug effects
b b b
Answer: d b
Textbook Reference: Pharmacology: The Science of Drug Action
b b b b b b b
2. After drug administration has occurred, the amount of drug in the blood that is free to
b b b b b b b b b b b b b b b
bind at specific target sites is referred to as
b b b b b b b b b
a. the therapeutic dose.
b b
b. first-pass effects. b
c. bioavailability.
d. ED50.
Answer: c b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
3. The specific molecular changes that occur when a drug binds to a particular target site
b b b b b b b b b b b b b b
or receptor are referred to as
b b b b b b
a. drug effects. b
b. drug action. b
c. side effects.b
d. placebo effects. b
Answer: b b
Textbook Reference: Pharmacology: The Science of Drug Action
b b b b b b b
4. Which of the following is not a possible explanation for placebo effects?
b b b b b b b b b b b
a. Pavlovian conditioning b
b. Genetic variation b
c. Drug competition b
d. Expectation of outcome b b
Answer: c b
Textbook Reference: Pharmacology: The Science of Drug Action
b b b b b b b
Page 1 of 247
b b b
,5. The administration of oxytocin has been proposed as a treatment for autism. b b b b b b b b b b
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
6. Which factor does not affect the pharmacokinetics of a drug?
b b b b b b b b b
a. Route of administration
b b
b. Lipid solubility
b
c. Depot binding b
d. Drug actionb
Answer: d b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
7. First-pass metabolism occurs when drugs are taken
b b b b b b
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
8. The area postrema is one area in the brain where the
b b is not complete.
b b b b b b b b b b
a. cerebrospinal fluid b
b. blood–brain barrier b
c. choroid plexus b
d. phospholipid membrane b
Answer: b b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
9. First-pass metabolism occurs with orally administered drugs because
b b b b b b b
a. their absorption is slowed by food.
b b b b b
b. drugs absorbed into the bloodstream from the stomach go to the liver on the way to
b b b b b b b b b b b b b b b
general circulation.
b b
c. drugs must first survive the acidic environment of the stomach.
b b b b b b b b b
d. salivary enzymes in the mouth begin the process of metabolism.
b b b b b b b b b
Answer: b b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
10. Toxic substances in the blood trigger a vomiting response by activating the
b b b b b b b b b b b
a. blood–brain barrier. b
b. choroid plexus. b
c. area postrema.
b
d. median eminence. b
Page 2 of 247
b b b
, Answer: c b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
11. Drugs administered _ have the most rapid onset of action.
b b b b b b b b
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
12. Ionization of a drug depends on the of the solution and the
b b b b b b b b b b of the
b
drug.
b
a. pH; pKa
b
b. pKa; pH b
c. concentration; lipid solubility b b
d. pH; concentration
b
Answer: a b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
13. The absorption of a drug depends on all of the following except
b b b b b b b b b b b
a. lipid solubility.
b
b. ionization.
c. body temperature.
b
d. the concentration of the drug.
b b b b
Answer: c b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
14. Drugs that are should be avoided by women of childbearing age.
b b b b b b b b b
a. teratogenic
b. able to cross the placental barrier
b b b b b
c. psychoactive
d. highly lipid-soluble b
Answer: a b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
15. Agents that induce developmental abnormalities in a fetus are known as
b b b b b b b b b b
a. psychoactive drugs. b
b. illicit drugs. b
c. teratogens.
d. placental drugs. b
Answer: c b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
16. Depot binding is said to occur when drugs
b b b b b b b
a. bind to their target sites.
b b b b
Page 3 of 247
b b b
to accompany
b
Psychopharmacology, Third Edition b b
Meyer • Quenzer b b
Chapter 1: Principles of Pharmacology b b b b
Multiple Choice b
1. refer(s) to specific molecular changes that occur when a drug binds to a
b b b b b b b b b b b b
particular target site or receptor, while
b b are the resulting widespread alterations
b b b b b b b b
in function.
b b
a. Drug action; therapeutic effects
b b b
b. Side effects; drug effects
b b b
c. Therapeutic effects; side effects b b b
d. Drug action; drug effects
b b b
Answer: d b
Textbook Reference: Pharmacology: The Science of Drug Action
b b b b b b b
2. After drug administration has occurred, the amount of drug in the blood that is free to
b b b b b b b b b b b b b b b
bind at specific target sites is referred to as
b b b b b b b b b
a. the therapeutic dose.
b b
b. first-pass effects. b
c. bioavailability.
d. ED50.
Answer: c b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
3. The specific molecular changes that occur when a drug binds to a particular target site
b b b b b b b b b b b b b b
or receptor are referred to as
b b b b b b
a. drug effects. b
b. drug action. b
c. side effects.b
d. placebo effects. b
Answer: b b
Textbook Reference: Pharmacology: The Science of Drug Action
b b b b b b b
4. Which of the following is not a possible explanation for placebo effects?
b b b b b b b b b b b
a. Pavlovian conditioning b
b. Genetic variation b
c. Drug competition b
d. Expectation of outcome b b
Answer: c b
Textbook Reference: Pharmacology: The Science of Drug Action
b b b b b b b
Page 1 of 247
b b b
,5. The administration of oxytocin has been proposed as a treatment for autism. b b b b b b b b b b
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
6. Which factor does not affect the pharmacokinetics of a drug?
b b b b b b b b b
a. Route of administration
b b
b. Lipid solubility
b
c. Depot binding b
d. Drug actionb
Answer: d b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
7. First-pass metabolism occurs when drugs are taken
b b b b b b
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
8. The area postrema is one area in the brain where the
b b is not complete.
b b b b b b b b b b
a. cerebrospinal fluid b
b. blood–brain barrier b
c. choroid plexus b
d. phospholipid membrane b
Answer: b b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
9. First-pass metabolism occurs with orally administered drugs because
b b b b b b b
a. their absorption is slowed by food.
b b b b b
b. drugs absorbed into the bloodstream from the stomach go to the liver on the way to
b b b b b b b b b b b b b b b
general circulation.
b b
c. drugs must first survive the acidic environment of the stomach.
b b b b b b b b b
d. salivary enzymes in the mouth begin the process of metabolism.
b b b b b b b b b
Answer: b b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
10. Toxic substances in the blood trigger a vomiting response by activating the
b b b b b b b b b b b
a. blood–brain barrier. b
b. choroid plexus. b
c. area postrema.
b
d. median eminence. b
Page 2 of 247
b b b
, Answer: c b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
11. Drugs administered _ have the most rapid onset of action.
b b b b b b b b
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
12. Ionization of a drug depends on the of the solution and the
b b b b b b b b b b of the
b
drug.
b
a. pH; pKa
b
b. pKa; pH b
c. concentration; lipid solubility b b
d. pH; concentration
b
Answer: a b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
13. The absorption of a drug depends on all of the following except
b b b b b b b b b b b
a. lipid solubility.
b
b. ionization.
c. body temperature.
b
d. the concentration of the drug.
b b b b
Answer: c b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
14. Drugs that are should be avoided by women of childbearing age.
b b b b b b b b b
a. teratogenic
b. able to cross the placental barrier
b b b b b
c. psychoactive
d. highly lipid-soluble b
Answer: a b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
15. Agents that induce developmental abnormalities in a fetus are known as
b b b b b b b b b b
a. psychoactive drugs. b
b. illicit drugs. b
c. teratogens.
d. placental drugs. b
Answer: c b
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
b b b b b b
16. Depot binding is said to occur when drugs
b b b b b b b
a. bind to their target sites.
b b b b
Page 3 of 247
b b b
