Lecture 7-GIP and GLP-1
glucose-dependent insulinotropic peptide - questions and answersGIP
Oral - questions and answers___ glucose gives greater insulin response than IV, IP, or
SC
reduced - questions and answersThere is a ____ incretin effect in people with Type 2
Diabetes
Food - questions and answers___ stimulates incretin secretion
7-36 - questions and answersThe bioactive form of GLP-1 is (___) amide
1-42 - questions and answersThe bioactive form of GIP is (___)
GLP-1
GIP - questions and answersDPP-4 converts ___ and ___ to their inactive metabolites
N - questions and answersDPP-4 cleaves off at the ___-terminus of each (GLP-1 and
GIP), inactivating them
2 - questions and answersDPP-4 cleaves off the first ___ amino acids of GIP and
GLP-1, deactivating them
portal
systemic - questions and answersDPP-4 is widely expressed, including on the surface
of ___ endothelial cells so a large proportion o GLP-1 and GIP never reach the ___
circulation
9-36
3-42 - questions and answersThe inactive form of GLP-1 is (___) amide and the inactive
form of GIP is (____)
GIP - questions and answersK cells release ___
duodenum - questions and answersK cells are primarily found in the ___
GLP-1 - questions and answersL cells release ___
, ileum and colon - questions and answersL cells are found distally, in the ___ and ___
peripheral - questions and answersGIP actions occur in ___ tissues
GIP and GLP-1 - questions and answersThe incretin effect is lost after ___ and ___ are
proteolyzed by DPP-4
nutrients - questions and answersGIP secretion is stimulated by ___
depolarization
GIP - questions and answersWhen K cells sense nutrients, they promote ___ of the
membrane, causing an increase of Ca2+ into the cell to release ___
directly - questions and answersThe Uptake pathway ___ takes up glucose and ions
2 and 5 - questions and answersThe Uptake pathway of glucose via the electroneutral
pathway into K cells occurs through the GLUT___ and GLUT___ transporters
1 and 3 - questions and answersThe Uptake pathway of glucose via the electrogenic
pathway into K cells occurs through SGLT___ and SGLT___
- questions and answers___ of glucose into the K cell occurs via the transporters
GLUT2 and GLUT 5 (electroneutral pathway) or SGLT1 and SGLT3 (electrogenic
pathway)
increase - questions and answersOnce glucose has entered into the K cell, this will ___
the ATP/ADP ratio, by generating more energy
Katp channel - questions and answersAn increase in ATP in the K cell inhibits the ___
channel, depolarizing the cell
does not - questions and answersThe Surface Detection pathway ___ transport things
into the cell directly
SGLT3 - questions and answersThe Surface Detection pathway of glucose in K cells,
via electrogenic path, involves the ___ transporter
Tas - questions and answersThe Surface Detection pathway of glucose in K cells, via
electroneutral path, involves the ___ receptor
glucose-dependent insulinotropic peptide - questions and answersGIP
Oral - questions and answers___ glucose gives greater insulin response than IV, IP, or
SC
reduced - questions and answersThere is a ____ incretin effect in people with Type 2
Diabetes
Food - questions and answers___ stimulates incretin secretion
7-36 - questions and answersThe bioactive form of GLP-1 is (___) amide
1-42 - questions and answersThe bioactive form of GIP is (___)
GLP-1
GIP - questions and answersDPP-4 converts ___ and ___ to their inactive metabolites
N - questions and answersDPP-4 cleaves off at the ___-terminus of each (GLP-1 and
GIP), inactivating them
2 - questions and answersDPP-4 cleaves off the first ___ amino acids of GIP and
GLP-1, deactivating them
portal
systemic - questions and answersDPP-4 is widely expressed, including on the surface
of ___ endothelial cells so a large proportion o GLP-1 and GIP never reach the ___
circulation
9-36
3-42 - questions and answersThe inactive form of GLP-1 is (___) amide and the inactive
form of GIP is (____)
GIP - questions and answersK cells release ___
duodenum - questions and answersK cells are primarily found in the ___
GLP-1 - questions and answersL cells release ___
, ileum and colon - questions and answersL cells are found distally, in the ___ and ___
peripheral - questions and answersGIP actions occur in ___ tissues
GIP and GLP-1 - questions and answersThe incretin effect is lost after ___ and ___ are
proteolyzed by DPP-4
nutrients - questions and answersGIP secretion is stimulated by ___
depolarization
GIP - questions and answersWhen K cells sense nutrients, they promote ___ of the
membrane, causing an increase of Ca2+ into the cell to release ___
directly - questions and answersThe Uptake pathway ___ takes up glucose and ions
2 and 5 - questions and answersThe Uptake pathway of glucose via the electroneutral
pathway into K cells occurs through the GLUT___ and GLUT___ transporters
1 and 3 - questions and answersThe Uptake pathway of glucose via the electrogenic
pathway into K cells occurs through SGLT___ and SGLT___
- questions and answers___ of glucose into the K cell occurs via the transporters
GLUT2 and GLUT 5 (electroneutral pathway) or SGLT1 and SGLT3 (electrogenic
pathway)
increase - questions and answersOnce glucose has entered into the K cell, this will ___
the ATP/ADP ratio, by generating more energy
Katp channel - questions and answersAn increase in ATP in the K cell inhibits the ___
channel, depolarizing the cell
does not - questions and answersThe Surface Detection pathway ___ transport things
into the cell directly
SGLT3 - questions and answersThe Surface Detection pathway of glucose in K cells,
via electrogenic path, involves the ___ transporter
Tas - questions and answersThe Surface Detection pathway of glucose in K cells, via
electroneutral path, involves the ___ receptor
