Lecture 7-GIP and GLP-1 Question with Verified Answers 2025

GIP - Ans-glucose-dependent insulinotropic peptide ___ glucose gives greater insulin response than IV, IP, or SC - Ans-Oral There is a ____ incretin effect in people with Type 2 Diabetes - Ans-reduced ___ stimulates incretin secretion - Ans-Food The bioactive form of GLP-1 is (___) amide - Ans-7-36 The bioactive form of GIP is (___) - Ans-1-42 DPP-4 converts ___ and ___ to their inactive metabolites - Ans-GLP-1 GIP DPP-4 cleaves off at the ___-terminus of each (GLP-1 and GIP), inactivating them - Ans-N DPP-4 cleaves off the first ___ amino acids of GIP and GLP-1, deactivating them - Ans-2 DPP-4 is widely expressed, including on the surface of ___ endothelial cells so a large proportion o GLP-1 and GIP never reach the ___ circulation - Ans-portal systemic The inactive form of GLP-1 is (___) amide and the inactive form of GIP is (____) Ans,,,,