Genetics Essentials: Concepts and Connections 5th Edition by
e e e e e e e
Benjamin A. Pierce
e e
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,TABLE OF CONTENT
e e
Chaptere01:eIntroductionetoeGenetics ........................................................................................................................ 3
Chaptere02:eChromosomeseandeCellulareReproduction ........................................................................................... 15
Chaptere03:eBasicePrincipleseofeHeredity ................................................................................................................ 32
Chaptere04:eExtensionseandeModificationseofeBasicePrinciples ............................................................................... 59
Chaptere05:eLinkage,eRecombination,eandeEukaryoticeGeneeMapping ................................................................... 98
Chaptere06:eChromosomeeVariation ..................................................................................................................... 115
Chaptere07:eBacterialeandeViraleGeneticeSystems.................................................................................................. 139
Chaptere08eDNA:eTheeChemicaleNatureeofetheeGene............................................................................................. 152
Chaptere09:eDNAeReplicationeandeRecombination ............................................................................................... 181
Chaptere10:eFromeDNAetoeProteins:eTranscriptioneandeRNAeProcessing .............................................................. 198
Chaptere11:eFromeDNAetoeProteins:eTranslation ................................................................................................... 224
Chaptere12:eControleofeGeneeExpression ............................................................................................................... 244
Chaptere13:eGeneeMutations,eTransposableeElements,eandeDNAeRepair .............................................................. 278
Chaptere14:eMoleculareGeneticeAnalysiseandeBiotechnology ................................................................................ 298
Chaptere15:eGenomicseandeProteomics ................................................................................................................. 314
Chaptere16:eCancereGenetics................................................................................................................................. 332
Chaptere17:eQuantitativeeGenetics ........................................................................................................................ 346
Chaptere18:ePopulationeandeEvolutionaryeGenetics .............................................................................................. 366
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,Chaptere01:eIntroductionetoeGenetics
1. Albinismeiserareeinemostehumanepopulations,eoccurringeateaefrequencyeofeaboute1eine20,000epeople.eHowever,ethe
etraiteoccurseateaefrequencyeofe1eine200einecertaineHopievillageseofeBlackeMesaeineArizona.eExplaineinetermseofenatura
leselectionewhyealbinismeisesoerareeinemostehumanepopulations.
ANSWER:eInemostepopulations,ethereeisefairlyestrongeselectioneagainstealbinismebecauseealbinosedon’teproduceemel
anin,ecausingetheireskinecellsenotetoebeeprotectedefrometheedamagingeeffectseofesunlight.eAlso,etheelackeo
femelanineinetheireeyesecausesethemetoehaveepooreeyesight.eFinally,einemosteculturesealbinoseareeseeneasea
bnormal,eandetheyeareenotenormallyesoughteouteforemarriageeandemating.eTherefore,einemostepopulation
setheeallelesethatecauseealbinismeareeselectedeagainst,eandetheyedecreaseeinefrequencyeoreareekepteateaelowe
level,ecausingetheerecessiveetraitetoebeerare.
2. Albinismeiserareeinemostehumanepopulations,eoccurringeateaefrequencyeofeaboute1eine20,000epeople.eHowever,ethe
etraiteoccurseateaefrequencyeofe1eine200einecertaineHopievillageseofeBlackeMesaeineArizona.eExplaineinetermseofenatura
leselectionewhyetheetraiteisesoemuchemoreecommoneamongetheeHopiseofeBlackeMesa.
ANSWER:eAlbinoseoccupyeaeprivilegedepositioneamongetheeHopiseofeBlackeMesa.eInethiseculture,ealbinoseareevi
ewedeaseespeciallyepretty,eclean,eandeintelligent,eandetheyeofteneoccupyepositionseofeleadership.eAlb
inoseareecelebratedeinetheevillageseaseaesigneofepurityeofeHopiebloodeinetheecommunity.
Furthermore,ealbinoseareeofteneexcusedefromenormalemaleefieldelaborebecauseeofetheiresensitivityetoesun
light,ecausingethemetoebeeleftebehindeinetheevillageewithetheewomeneduringetheedaytime.eThiseallowsethe
meextraematingeopportunitiesecomparedetoetheeotheremeneofetheevillage.eTherefore,etheeallelesethatecaus
eealbinismeareeeithereselectedeforeinethisecultureeoreateleastenoteselectedeagainsteasestronglyeaseineotherecu
ltures,eallowingetheetraitetoeoccureateaemuchehigherefrequency.
3. WhicheoneeofetheefollowingepairingsebetweenetheesubdisciplineeofegeneticseandetheephenomenoneiseI
NCORRECT?
a. evolution—populationegenetics
b. geneeregulation—molecularegenetics
c. allelicefrequencyealteration—populationegenetics
d. arrangementeofegeneseonechromosome—transmissionegenetics
e. chemicalenatureeofetheegene—transmissionegenetics
ANSWER:ee
4. Whicheoneeofetheefollowingetopicseoferesearchebelongsetoetheedisciplineeofetransmissionegenetics?
a. inheritanceepatterneofegeneealleles
b. mechanismeofeDNAereplication
c. geneeexpressionepatterns
d. evolution
e. chemicalemodificationeofenucleiceacids
ANSWER:ea
5. Theecompleteegeneticemakeupeofeaneorganismeisereferredetoeaseits
a. chromosome.
b. alleles.
c. locus.
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, d. genome.
e. phenotype.
ANSWER:ed
6. IdentifyeaeTRUEestatementefrometheefollowingedescriptionseconcerningegenetics.
a. Theetheoryeofepangenesisestatesethateallelivingeorganismseareecomposedeofecells.
b. Bacteriaeandeviruseseareenoteusefuleinestudyingegeneseandeinheritanceebecauseetheyeareestructurallyea
ndemetabolicallyedifferentefromeeukaryoticecells.
c. CharleseDarwineaccuratelyedescribedetheelawseofeinheritanceeinehiselandmarkebook,eOnetheeOrigineofeSp
ecies.
d. Manyehumanetraits,esucheaseskineandehairecolor,eareedeterminedebyemoreethaneaesingleegene.
e. Evolutionecaneoccurewithoutegeneticechangeseinetheepopulation.
ANSWER:ed
7. IdentifyeaeFALSEestatementefrometheefollowingedescriptionseofegenetics.
a. Humansefirsteappliedegeneticsetoetheedomesticationeofeplantseandeanimalsebetweeneapproximatelye1
0,000eande12,000eyearseago.
b. SomeeviruseseuseeRNAetoecarryetheiregeneticeinformation.
c. Albinismeresultsefromeaemutationeinetheegenesethatecontroletheesynthesiseandestorageeofemelanin.
d. Allehumanetraitsethatedisplayeblendingeinheritanceeareeaffectedebyeaesingleegene.
e. Theeprocessebyewhichegeneticeinformationeisecopiedeandedecodedeisesimilareforealleformseofelife.
ANSWER:ed
8. Whicheofetheefollowingespecieseiseconsideredeaemodelegeneticeorganism?
a. theeplanteLinariaevulgaris
b. theedeeremouseePeromyscusemaniculatus
c. theewormeCaenorhabditiseelegans
d. theefrogeHylaechrysoscelis
e. theechimpanzeeePanetroglodytese
ANSWER:ec
9. WhicheofetheefollowingewouldeserveetheeLEASTewelleaseaemodeleforeunderstandingebasicemechanismseofein
heritance?
a. fruiteflies
b. humans
c. yeast
d. mice
e. zebrafish
ANSWER:eb
10. WhicheofetheefollowingestatementseiseTRUE?
a. Eachesubdisciplineeofegeneticseiseveryespecificeasetoewhateiseexploredeandedoesenoteoverlapewithethe
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