NR565- Advance Pharmacology
Amlodipine
Common dose
Directions for use
Indication - ANS -Essential HTN & Angina
5-10mg/daily
\· Colchicine
Common dose
Directions for use
Indication - ANS -Gout attack
start tx at the first sign of attack, and stop use is side effects occur
0.6-1.2mg q12-daily as recommended
\· Hydrocodone/Acetaminophen (Lortab)
Common dose
Directions for use
Indication - ANS -Pain
5mg/325mg- 1-2 tabs q4-6h
7.5mg/325mg- 1tab q4-6h
10mg/325mg- 1tab q4-6h
\· Lisinopril
Common dose
Directions for use
Indication - ANS -HTN- 10-40 mg once/d
HF- 20-40 mg once/day
Acute MI- 10 mg once/day for at least 6 weeks
\Atherosclerotic Cardiovascular Disease (ASCVD) Risk Score
, o What is it?
o When is it used? - ANS -ASCVD risk assessment is directed at determining the patient's absolute risk of developing the
clinical coronary disease over the next 10 years. Defines high risk as 7.5% or greater. A calculation of your 10-year risk of
having a cardiovascular problem, such as a heart attack or stroke.
In children, screening should be done between ages 9 and 11 and then again at ages 19 and 21. For adults every 5 years
after the age of 20. Some people are at greater risk like those with diabetes and a risk score greater than 7.5% and
should be screened more often
\Be familiar with pharmacokinetic and pharmacodynamic changes of older adults and how that would translate to baseline
information needed to prescribe. - ANS -increase glomerular filtration rate leads to increase drug excretion
increase hepatic metabolism
decrease tone and motility of bowel
increase drug absorption
\Beer's Criteria- What is it and Why is it important - ANS -Recommendations of medications inappropriate for elderly (65
and older)
Prevents adverse drug reactions
\Behaviors that predict controlled substance addiction - ANS -chronic pain
family history
other substance abuse
prescribed for long-term use
\Best approach or drug to use for HTN during pregnancy or someone wishing to become pregnant - ANS -labetalol
methyldopa
nifedipine
\Beta-blockers
o Their use with nitroglycerin and tachycardia
o Know examples
o Risk of stopping them abruptly
o What happens when given to someone with asthma? - ANS --Beta Blockers suppress nitroglycerin-induced tachycardia.
They do so by preventing sympathetic activation of beta-1 adrenergic receptors in the heart.
Amlodipine
Common dose
Directions for use
Indication - ANS -Essential HTN & Angina
5-10mg/daily
\· Colchicine
Common dose
Directions for use
Indication - ANS -Gout attack
start tx at the first sign of attack, and stop use is side effects occur
0.6-1.2mg q12-daily as recommended
\· Hydrocodone/Acetaminophen (Lortab)
Common dose
Directions for use
Indication - ANS -Pain
5mg/325mg- 1-2 tabs q4-6h
7.5mg/325mg- 1tab q4-6h
10mg/325mg- 1tab q4-6h
\· Lisinopril
Common dose
Directions for use
Indication - ANS -HTN- 10-40 mg once/d
HF- 20-40 mg once/day
Acute MI- 10 mg once/day for at least 6 weeks
\Atherosclerotic Cardiovascular Disease (ASCVD) Risk Score
, o What is it?
o When is it used? - ANS -ASCVD risk assessment is directed at determining the patient's absolute risk of developing the
clinical coronary disease over the next 10 years. Defines high risk as 7.5% or greater. A calculation of your 10-year risk of
having a cardiovascular problem, such as a heart attack or stroke.
In children, screening should be done between ages 9 and 11 and then again at ages 19 and 21. For adults every 5 years
after the age of 20. Some people are at greater risk like those with diabetes and a risk score greater than 7.5% and
should be screened more often
\Be familiar with pharmacokinetic and pharmacodynamic changes of older adults and how that would translate to baseline
information needed to prescribe. - ANS -increase glomerular filtration rate leads to increase drug excretion
increase hepatic metabolism
decrease tone and motility of bowel
increase drug absorption
\Beer's Criteria- What is it and Why is it important - ANS -Recommendations of medications inappropriate for elderly (65
and older)
Prevents adverse drug reactions
\Behaviors that predict controlled substance addiction - ANS -chronic pain
family history
other substance abuse
prescribed for long-term use
\Best approach or drug to use for HTN during pregnancy or someone wishing to become pregnant - ANS -labetalol
methyldopa
nifedipine
\Beta-blockers
o Their use with nitroglycerin and tachycardia
o Know examples
o Risk of stopping them abruptly
o What happens when given to someone with asthma? - ANS --Beta Blockers suppress nitroglycerin-induced tachycardia.
They do so by preventing sympathetic activation of beta-1 adrenergic receptors in the heart.
