IMMUNOLOGY EXAM #5 WEIGEL
QUESTIONS AND ANSWERS
It's a receptor present on the _____________ membrane of ___________ cells that
binds ____________, especially dimeric ______ but also _______, and transports
them across the epithelium by _______________. - Answer-basolateral ; epithelial ;
polymeric Igs ; IgA ; IgM ; transcytosis
Define transcytosis:
It's "______________________________________________________________."
"The transport of molecules from one side of an ________________ to the other by
______________ into vesicles within the epithelial cells at one face of the the
epithelium and release of the vesicles at the other." - Answer-receptor mediated
transport from one side of a cell to the other of a macromolecule ; epithelium ;
endocytosis
Which antibody is passed across the placenta and provides early immunity to the
infant? How is it get across the placenta (which receptor is used)?
_______ is the antibody passed across the placenta and provides early immunity to
the infant. It gets across the placenta through _________________ directly into the
babies' blood stream. "Transport of the IgG antibodies across the placenta is also
mediated by the _______." - Answer-IgG ; maternal circulation ; FcRB
Which antibody is in the breast milk and once in the baby what does it protect?
_______ is in the breast milk and once in the baby it's "transferred to (the) baby's
_______" where it "bind(s) to microorganism(s) preventing _____________ to the
gut epithelium." It "pass(es) in the _______". - Answer-IgA ; gut ; attachment ; feces
Is anti-venom a passive transfer of Ab?
____. The anti-vemon antibodies are created by immunizing large domestic animals,
such as horses, with venom. These antibodies are then infused with the patient to
neutralize the toxins. This is done for immediate protection and doesn't produce long
term immunity. - Answer-Yes
Define passive transfer of immunity. Know a couple of examples.
"__________________________________________________________________
_______"
-Transfer of preformed _______ from mother to child in breast milk
-Intravenous immunoglobulin given to patients with genetic defects in B-cell function
-___________________ - Answer-Transfer of immunity to a non-immune individual
by the injection of specific antibody, immune serum, or T cells ; IgA ; Anti-venom
, What are immune complexes composed of and which cell plays a large role in their
uptake and destruction?
Immune complexes are composed of _________ binding to _________________
and sometimes ___________. The cell that plays a large role in their uptake and
destruction are _______________, which deliver the immune complexes to the
_______ and ________ where they are degraded by __________________. -
Answer-antibodies ; soluble antigens ; complement ; erythrocytes ; liver ; spleen ;
macrophages
What is dimeric IgA used for and where is it made?
___________ is used for ____________ epithelia surfaces that communicate with
external environment (mucosal membranes susceptible to infection) such as the
linings of the GI tract, eyes, nose, throat, mammary glands, respiratory, urinary and
genital tracts.
It's made in the ___________________________ underlying _________________
aka the lamina propria. - Answer-Dimeric IgA ; protecting ; secondary lymphoid
tissue ; mucosal surfaces
What are the main purposes of Fc receptors? (2 main purposes) - Answer-Deliver
antibodies to sites where they would not be carried by blood and lymph circulation ;
Attach Ag:Ab complexes to effectors cells allowing effector cells to destroy the
pathogens
What is ADCC?
Stands for: ____________________________________________
"This...is the mechanism by the therapeutic monoclonal antibody rituximab
eliminates B cells and B-cell tumors." "The killing of antibody-coated target cells by
NK cells having the receptor FcγRIII (CD16), which recognizes the Fc region of the
bound antibody." - Answer-Antibody-dependent cell-mediated cytotoxicity ;
How do antibodies function? Do they destroy the pathogen directly or do they tag
and cover up things?
Antibodies ______ destroy the pathogen directly. They do 3 things: ____________,
____________, and ____________ - Answer-don't ; neutralization ; opsonization ;
complement activation
Neutralization: - Answer-It covers up all the sites that the Ag would use to bind with
cells
Opsonization: - Answer-Tagging pathogens for phagocytosis
Complement activation: - Answer-Complement Activation of the classical pathway
Antigen binding (does the B cell take up the antigen, what is this called)
Binding of antigen sends a signal to the B cells' _________ to change
_______________. Yes the B cell takes up the ________ by internalizing Ag by
QUESTIONS AND ANSWERS
It's a receptor present on the _____________ membrane of ___________ cells that
binds ____________, especially dimeric ______ but also _______, and transports
them across the epithelium by _______________. - Answer-basolateral ; epithelial ;
polymeric Igs ; IgA ; IgM ; transcytosis
Define transcytosis:
It's "______________________________________________________________."
"The transport of molecules from one side of an ________________ to the other by
______________ into vesicles within the epithelial cells at one face of the the
epithelium and release of the vesicles at the other." - Answer-receptor mediated
transport from one side of a cell to the other of a macromolecule ; epithelium ;
endocytosis
Which antibody is passed across the placenta and provides early immunity to the
infant? How is it get across the placenta (which receptor is used)?
_______ is the antibody passed across the placenta and provides early immunity to
the infant. It gets across the placenta through _________________ directly into the
babies' blood stream. "Transport of the IgG antibodies across the placenta is also
mediated by the _______." - Answer-IgG ; maternal circulation ; FcRB
Which antibody is in the breast milk and once in the baby what does it protect?
_______ is in the breast milk and once in the baby it's "transferred to (the) baby's
_______" where it "bind(s) to microorganism(s) preventing _____________ to the
gut epithelium." It "pass(es) in the _______". - Answer-IgA ; gut ; attachment ; feces
Is anti-venom a passive transfer of Ab?
____. The anti-vemon antibodies are created by immunizing large domestic animals,
such as horses, with venom. These antibodies are then infused with the patient to
neutralize the toxins. This is done for immediate protection and doesn't produce long
term immunity. - Answer-Yes
Define passive transfer of immunity. Know a couple of examples.
"__________________________________________________________________
_______"
-Transfer of preformed _______ from mother to child in breast milk
-Intravenous immunoglobulin given to patients with genetic defects in B-cell function
-___________________ - Answer-Transfer of immunity to a non-immune individual
by the injection of specific antibody, immune serum, or T cells ; IgA ; Anti-venom
, What are immune complexes composed of and which cell plays a large role in their
uptake and destruction?
Immune complexes are composed of _________ binding to _________________
and sometimes ___________. The cell that plays a large role in their uptake and
destruction are _______________, which deliver the immune complexes to the
_______ and ________ where they are degraded by __________________. -
Answer-antibodies ; soluble antigens ; complement ; erythrocytes ; liver ; spleen ;
macrophages
What is dimeric IgA used for and where is it made?
___________ is used for ____________ epithelia surfaces that communicate with
external environment (mucosal membranes susceptible to infection) such as the
linings of the GI tract, eyes, nose, throat, mammary glands, respiratory, urinary and
genital tracts.
It's made in the ___________________________ underlying _________________
aka the lamina propria. - Answer-Dimeric IgA ; protecting ; secondary lymphoid
tissue ; mucosal surfaces
What are the main purposes of Fc receptors? (2 main purposes) - Answer-Deliver
antibodies to sites where they would not be carried by blood and lymph circulation ;
Attach Ag:Ab complexes to effectors cells allowing effector cells to destroy the
pathogens
What is ADCC?
Stands for: ____________________________________________
"This...is the mechanism by the therapeutic monoclonal antibody rituximab
eliminates B cells and B-cell tumors." "The killing of antibody-coated target cells by
NK cells having the receptor FcγRIII (CD16), which recognizes the Fc region of the
bound antibody." - Answer-Antibody-dependent cell-mediated cytotoxicity ;
How do antibodies function? Do they destroy the pathogen directly or do they tag
and cover up things?
Antibodies ______ destroy the pathogen directly. They do 3 things: ____________,
____________, and ____________ - Answer-don't ; neutralization ; opsonization ;
complement activation
Neutralization: - Answer-It covers up all the sites that the Ag would use to bind with
cells
Opsonization: - Answer-Tagging pathogens for phagocytosis
Complement activation: - Answer-Complement Activation of the classical pathway
Antigen binding (does the B cell take up the antigen, what is this called)
Binding of antigen sends a signal to the B cells' _________ to change
_______________. Yes the B cell takes up the ________ by internalizing Ag by
