Lehne's Pharmacotherapeutics for Advanced Practice Nurses and Physician Assistants 3rd Edition
by Laura D. Rosenthal DNP RN ACNP-BC FAANP, Jacqueline Rosenjack Burchum DNSc FNP-BC CNE (2025)
||LATEST EDITION||ALL CHAPTERS WITH 15 UNITS || FULL TEST BANK
,Table of Contents
UNIT I: INTRODUCTION ............................................................................................................................................. 5
Chapter 1: Prescriptive Authority .......................................................................................................................................... 5
Chapter 2: Rational Drug Selection And Prescription Writing ............................................................................................. 7
Chapter 3: Promoting Positive Outcomes Of Drug Therapy................................................................................................. 9
UNIT II: BASIC PRINCIPLES OF PHARMACOLOGY .................................................................................................... 12
Chapter 4: Pharmacokinetics, Pharmacodynamics, And Drug Interactions ........................................................................ 12
Chapter 5: Adverse Drug Reactions And Medication Errors .............................................................................................. 19
Chapter 6: Individual Variation In Drug Responses ........................................................................................................... 24
Chapter 7: Genetic And Genomic Considerations In Pharmacotherapeutics ...................................................................... 29
UNIT III: DRUG THERAPY ACROSS THE LIFE SPAN ................................................................................................... 35
Chapter 8: Drug Therapy During Pregnancy And Breast-Feeding ...................................................................................... 35
Chapter 9: Drug Therapy In Pediatric Patients.................................................................................................................... 39
Chapter 10: Drug Therapy In Geriatric Patients.................................................................................................................. 44
UNIT IV: PERIPHERAL NERVOUS SYSTEM DRUGS ................................................................................................... 49
Chapter 11: Basic Principles Of Neuropharmacology ........................................................................................................ 49
Chapter 12: Physiology Of The Peripheral Nervous System .............................................................................................. 52
Chapter 13: Muscarinic Agonists ........................................................................................................................................ 55
Chapter 14 Muscarinic Antagonists ..................................................................................................................................... 58
Chapter 15: Adrenergic Agonists......................................................................................................................................... 63
Chapter 16: Adrenergic Antagonists ................................................................................................................................... 67
Chapter 17: Indirect-Acting Antiadrenergic Agents ........................................................................................................... 72
UNIT V: CENTRAL NERVOUS SYSTEM DRUGS ......................................................................................................... 76
Chapter 18: Introduction To Central Nervous System Pharmacology................................................................................. 76
Chapter 19: Drugs For Parkinson's Disease ........................................................................................................................ 79
Chapter 20: Drugs For Alzheimer's Disease ....................................................................................................................... 83
Chapter 21: Drugs For Seizure Disorders ........................................................................................................................... 87
Chapter 22: Drugs For Muscle Spasm And Spasticity......................................................................................................... 92
UNIT VI: DRUGS FOR PAIN ...................................................................................................................................... 96
Chapter 23: Local Anesthetics ............................................................................................................................................. 96
Chapter 24: Opioid Analgesics, Opioid Antagonists, And Nonopioid Centrally Acting Analgesics ................................ 100
Chapter 25: Drugs For Headache ...................................................................................................................................... 105
UNIT VII: PSYCHOTHERAPEUTIC DRUGS ............................................................................................................... 110
Chapter 26: Antipsychotic Agents And Their Use In Schizophrenia ................................................................................ 110
Chapter 27: Antidepressants .............................................................................................................................................. 117
Chapter 28: Drugs For Bipolar Disorder ........................................................................................................................... 122
Chapter 29: Sedative-Hypnotic Drugs............................................................................................................................... 127
Chapter 30: Management Of Anxiety Disorders ............................................................................................................... 131
Chapter 31: Central Nervous System Stimulants And Attention-Deficit/Hyperactivity Disorder .................................... 135
,UNIT VIII: SUBSTANCE USE DISORDERS ................................................................................................................ 139
Chapter 32: Drug Abuse I: Basic Considerations .............................................................................................................. 139
Chapter 33: Drug Abuse II: Alcohol ................................................................................................................................. 143
Chapter 34: Drug Abuse III: Nicotine And Smoking ........................................................................................................ 149
Chapter 35: Drug Abuse IV: Major Drugs Of Abuse Other Than Alcohol And Nicotine ................................................. 152
Chapter 36: Review Of Hemodynamics ............................................................................................................................ 161
UNIT IX: DRUGS THAT AFFECT THE HEART, BLOOD VESSELS, BLOOD, AND BLOOD VOLUME36. Review of
Hemodynamics ..................................................................................................................................................... 164
Chapter 37: Diuretics ......................................................................................................................................................... 164
Chapter 38: Drugs Acting On The Renin-Angiotensin-Aldosterone System.................................................................... 168
Chapter 39: Calcium Channel Blockers ............................................................................................................................ 173
Chapter 40: Vasodilators ................................................................................................................................................... 176
Chapter 41: Drugs For Hypertension ................................................................................................................................. 181
Chapter 42: Drugs For Heart Failure ................................................................................................................................. 188
Chapter 43: Antidysrhythmic Drugs .................................................................................................................................. 197
Chapter 44: Prophylaxis Of Atherosclerotic Cardiovascular Disease: Drugs That Help Normalize Cholesterol And
Triglyceride Levels............................................................................................................................................................ 205
Chapter 45: Drugs For Angina Pectoris ............................................................................................................................ 212
Chapter 46: Anticoagulant, Antiplatelet, And Thrombolytic Drugs ................................................................................. 218
Chapter 47: Drugs For Deficiency Anemias ...................................................................................................................... 226
UNIT X: DRUGS FOR ENDOCRINE DISORDERS ...................................................................................................... 232
Chapter 48: Drugs For Diabetes Mellitus .......................................................................................................................... 232
Chapter 49: Drugs For Thyroid Disorders ......................................................................................................................... 237
UNIT XI: WOMEN'S HEALTH .................................................................................................................................. 243
Chapter 50: Estrogens And Progestins: Basic Pharmacology And Noncontraceptive Applications.................................. 243
Chapter 51: Birth Control .................................................................................................................................................. 246
UNIT XII: MEN'S HEALTH ....................................................................................................................................... 253
Chapter 52: Androgens ...................................................................................................................................................... 253
Chapter 53: Drugs For Erectile Dysfunction And Benign Prostatic Hyperplasia ............................................................. 256
UNIT XIII: ANTI-INFLAMMATORY, ANTIALLERGIC, AND IMMUNOLOGIC DRUGS ................................................ 259
Chapter 54: Review Of The Immune System.................................................................................................................... 259
Chapter 55: Childhood Immunization ............................................................................................................................... 262
Chapter 56: Antihistamines ............................................................................................................................................... 268
Chapter 57: Cyclooxygenase Inhibitors: Nonsteroidal Anti-Inflammatory Drugs And Acetaminophen........................... 273
Chapter 58: Glucocorticoids In Nonendocrine Disorders ................................................................................................. 279
UNIT XIV: DRUGS FOR BONE AND JOINT DISORDERS ........................................................................................... 285
Chapter 59: Drug Therapy Of Rheumatoid Arthritis ........................................................................................................ 285
Chapter 60: Drug Therapy Of Gout .................................................................................................................................. 289
Chapter 61: Drugs Affecting Calcium Levels And Bone Mineralization ......................................................................... 292
UNIT XV: RESPIRATORY TRACT DRUGS ................................................................................................................. 299
, Chapter 62: Drugs For Asthma And Chronic Obstructive Pulmonary Disease ................................................................. 299
Chapter 63: Drugs For Allergic Rhinitis, Cough, And Colds ........................................................................................... 306
UNIT XVI: GASTROINTESTINAL DRUGS ................................................................................................................. 311
Chapter 64: Drugs For Peptic Ulcer Disease ..................................................................................................................... 311
Chapter 65: Laxatives........................................................................................................................................................ 317
Chapter 66: Other Gastrointestinal Drugs ......................................................................................................................... 323
UNIT XVII: NUTRITION AND COMPLIMENTARY THERAPIES ................................................................................. 331
Chapter 67: Vitamins ......................................................................................................................................................... 331
Chapter 68: Drugs For Weight Loss.................................................................................................................................. 336
Chapter 69: Complementary And Alternative Therapies .................................................................................................. 341
UNIT XIII: THERAPY OF INFECTIOUS AND PARASITIC DISEASES............................................................................ 344
Chapter 70: Basic Principles Of Antimicrobial Therapy ................................................................................................... 344
Chapter 71: Drugs That Weaken The Bacterial Cell Wall I: Penicillins ............................................................................ 349
Chapter 72: Drugs That Weaken The Bacterial Cell Wall II: Other Drugs....................................................................... 354
Chapter 73: Bacteriostatic Inhibitors Of Protein Synthesis ............................................................................................... 360
Chapter 74: Aminoglycosides: Bactericidal Inhibitors Of Protein Synthesis ................................................................... 368
Chapter 75: Sulfonamides And Trimethoprim .................................................................................................................. 376
Chapter 76: Drug Therapy Of Urinary Tract Infections..................................................................................................... 382
Chapter 77: Antimycobacterial Agents ............................................................................................................................. 389
Chapter 78: Miscellaneous Antibacterial Drugs................................................................................................................ 396
Chapter 79: Antifungal Agents.......................................................................................................................................... 400
Chapter 80: Antiviral Agents I: Drugs For Non-HIV Viral Infections ............................................................................. 410
Chapter 81: Antiviral Agents II: Drugs For HIV Infection And Related Opportunistic Infections ................................... 416
Chapter 82: Drug Therapy Of Sexually Transmitted Diseases .......................................................................................... 421
Chapter 83: Anthelmintics, Antiprotozoal Drugs, And Ectoparasiticides......................................................................... 425
UNIT XIX: CANCER THERAPY ................................................................................................................................. 430
Chapter 84 Introduction To Immunomodulators ............................................................................................................... 430
Chapter 85: Supportive Care Of Patients Receiving Anticancer Drugs ............................................................................ 441
Chapter 86: Drugs For Cancer Pain .................................................................................................................................. 449
UNIT XX: Drugs for Eyes, Ears, and Skin ................................................................................................................ 456
Chapter 87: Drugs For The Eye ........................................................................................................................................ 456
Chapter 88: Drugs For The Skin ....................................................................................................................................... 461
Chapter 89: Drugs For The Ear ......................................................................................................................................... 473
Chapter 90: Agents Affecting The Volume And Ion Content Of Body Fluids ................................................................. 479
Chapter 91: Management Of ST-Elevation Myocardial Infarction ................................................................................... 488
Chapter 92: Additional Acute Care Drugs ........................................................................................................................ 495
by Laura D. Rosenthal DNP RN ACNP-BC FAANP, Jacqueline Rosenjack Burchum DNSc FNP-BC CNE (2025)
||LATEST EDITION||ALL CHAPTERS WITH 15 UNITS || FULL TEST BANK
,Table of Contents
UNIT I: INTRODUCTION ............................................................................................................................................. 5
Chapter 1: Prescriptive Authority .......................................................................................................................................... 5
Chapter 2: Rational Drug Selection And Prescription Writing ............................................................................................. 7
Chapter 3: Promoting Positive Outcomes Of Drug Therapy................................................................................................. 9
UNIT II: BASIC PRINCIPLES OF PHARMACOLOGY .................................................................................................... 12
Chapter 4: Pharmacokinetics, Pharmacodynamics, And Drug Interactions ........................................................................ 12
Chapter 5: Adverse Drug Reactions And Medication Errors .............................................................................................. 19
Chapter 6: Individual Variation In Drug Responses ........................................................................................................... 24
Chapter 7: Genetic And Genomic Considerations In Pharmacotherapeutics ...................................................................... 29
UNIT III: DRUG THERAPY ACROSS THE LIFE SPAN ................................................................................................... 35
Chapter 8: Drug Therapy During Pregnancy And Breast-Feeding ...................................................................................... 35
Chapter 9: Drug Therapy In Pediatric Patients.................................................................................................................... 39
Chapter 10: Drug Therapy In Geriatric Patients.................................................................................................................. 44
UNIT IV: PERIPHERAL NERVOUS SYSTEM DRUGS ................................................................................................... 49
Chapter 11: Basic Principles Of Neuropharmacology ........................................................................................................ 49
Chapter 12: Physiology Of The Peripheral Nervous System .............................................................................................. 52
Chapter 13: Muscarinic Agonists ........................................................................................................................................ 55
Chapter 14 Muscarinic Antagonists ..................................................................................................................................... 58
Chapter 15: Adrenergic Agonists......................................................................................................................................... 63
Chapter 16: Adrenergic Antagonists ................................................................................................................................... 67
Chapter 17: Indirect-Acting Antiadrenergic Agents ........................................................................................................... 72
UNIT V: CENTRAL NERVOUS SYSTEM DRUGS ......................................................................................................... 76
Chapter 18: Introduction To Central Nervous System Pharmacology................................................................................. 76
Chapter 19: Drugs For Parkinson's Disease ........................................................................................................................ 79
Chapter 20: Drugs For Alzheimer's Disease ....................................................................................................................... 83
Chapter 21: Drugs For Seizure Disorders ........................................................................................................................... 87
Chapter 22: Drugs For Muscle Spasm And Spasticity......................................................................................................... 92
UNIT VI: DRUGS FOR PAIN ...................................................................................................................................... 96
Chapter 23: Local Anesthetics ............................................................................................................................................. 96
Chapter 24: Opioid Analgesics, Opioid Antagonists, And Nonopioid Centrally Acting Analgesics ................................ 100
Chapter 25: Drugs For Headache ...................................................................................................................................... 105
UNIT VII: PSYCHOTHERAPEUTIC DRUGS ............................................................................................................... 110
Chapter 26: Antipsychotic Agents And Their Use In Schizophrenia ................................................................................ 110
Chapter 27: Antidepressants .............................................................................................................................................. 117
Chapter 28: Drugs For Bipolar Disorder ........................................................................................................................... 122
Chapter 29: Sedative-Hypnotic Drugs............................................................................................................................... 127
Chapter 30: Management Of Anxiety Disorders ............................................................................................................... 131
Chapter 31: Central Nervous System Stimulants And Attention-Deficit/Hyperactivity Disorder .................................... 135
,UNIT VIII: SUBSTANCE USE DISORDERS ................................................................................................................ 139
Chapter 32: Drug Abuse I: Basic Considerations .............................................................................................................. 139
Chapter 33: Drug Abuse II: Alcohol ................................................................................................................................. 143
Chapter 34: Drug Abuse III: Nicotine And Smoking ........................................................................................................ 149
Chapter 35: Drug Abuse IV: Major Drugs Of Abuse Other Than Alcohol And Nicotine ................................................. 152
Chapter 36: Review Of Hemodynamics ............................................................................................................................ 161
UNIT IX: DRUGS THAT AFFECT THE HEART, BLOOD VESSELS, BLOOD, AND BLOOD VOLUME36. Review of
Hemodynamics ..................................................................................................................................................... 164
Chapter 37: Diuretics ......................................................................................................................................................... 164
Chapter 38: Drugs Acting On The Renin-Angiotensin-Aldosterone System.................................................................... 168
Chapter 39: Calcium Channel Blockers ............................................................................................................................ 173
Chapter 40: Vasodilators ................................................................................................................................................... 176
Chapter 41: Drugs For Hypertension ................................................................................................................................. 181
Chapter 42: Drugs For Heart Failure ................................................................................................................................. 188
Chapter 43: Antidysrhythmic Drugs .................................................................................................................................. 197
Chapter 44: Prophylaxis Of Atherosclerotic Cardiovascular Disease: Drugs That Help Normalize Cholesterol And
Triglyceride Levels............................................................................................................................................................ 205
Chapter 45: Drugs For Angina Pectoris ............................................................................................................................ 212
Chapter 46: Anticoagulant, Antiplatelet, And Thrombolytic Drugs ................................................................................. 218
Chapter 47: Drugs For Deficiency Anemias ...................................................................................................................... 226
UNIT X: DRUGS FOR ENDOCRINE DISORDERS ...................................................................................................... 232
Chapter 48: Drugs For Diabetes Mellitus .......................................................................................................................... 232
Chapter 49: Drugs For Thyroid Disorders ......................................................................................................................... 237
UNIT XI: WOMEN'S HEALTH .................................................................................................................................. 243
Chapter 50: Estrogens And Progestins: Basic Pharmacology And Noncontraceptive Applications.................................. 243
Chapter 51: Birth Control .................................................................................................................................................. 246
UNIT XII: MEN'S HEALTH ....................................................................................................................................... 253
Chapter 52: Androgens ...................................................................................................................................................... 253
Chapter 53: Drugs For Erectile Dysfunction And Benign Prostatic Hyperplasia ............................................................. 256
UNIT XIII: ANTI-INFLAMMATORY, ANTIALLERGIC, AND IMMUNOLOGIC DRUGS ................................................ 259
Chapter 54: Review Of The Immune System.................................................................................................................... 259
Chapter 55: Childhood Immunization ............................................................................................................................... 262
Chapter 56: Antihistamines ............................................................................................................................................... 268
Chapter 57: Cyclooxygenase Inhibitors: Nonsteroidal Anti-Inflammatory Drugs And Acetaminophen........................... 273
Chapter 58: Glucocorticoids In Nonendocrine Disorders ................................................................................................. 279
UNIT XIV: DRUGS FOR BONE AND JOINT DISORDERS ........................................................................................... 285
Chapter 59: Drug Therapy Of Rheumatoid Arthritis ........................................................................................................ 285
Chapter 60: Drug Therapy Of Gout .................................................................................................................................. 289
Chapter 61: Drugs Affecting Calcium Levels And Bone Mineralization ......................................................................... 292
UNIT XV: RESPIRATORY TRACT DRUGS ................................................................................................................. 299
, Chapter 62: Drugs For Asthma And Chronic Obstructive Pulmonary Disease ................................................................. 299
Chapter 63: Drugs For Allergic Rhinitis, Cough, And Colds ........................................................................................... 306
UNIT XVI: GASTROINTESTINAL DRUGS ................................................................................................................. 311
Chapter 64: Drugs For Peptic Ulcer Disease ..................................................................................................................... 311
Chapter 65: Laxatives........................................................................................................................................................ 317
Chapter 66: Other Gastrointestinal Drugs ......................................................................................................................... 323
UNIT XVII: NUTRITION AND COMPLIMENTARY THERAPIES ................................................................................. 331
Chapter 67: Vitamins ......................................................................................................................................................... 331
Chapter 68: Drugs For Weight Loss.................................................................................................................................. 336
Chapter 69: Complementary And Alternative Therapies .................................................................................................. 341
UNIT XIII: THERAPY OF INFECTIOUS AND PARASITIC DISEASES............................................................................ 344
Chapter 70: Basic Principles Of Antimicrobial Therapy ................................................................................................... 344
Chapter 71: Drugs That Weaken The Bacterial Cell Wall I: Penicillins ............................................................................ 349
Chapter 72: Drugs That Weaken The Bacterial Cell Wall II: Other Drugs....................................................................... 354
Chapter 73: Bacteriostatic Inhibitors Of Protein Synthesis ............................................................................................... 360
Chapter 74: Aminoglycosides: Bactericidal Inhibitors Of Protein Synthesis ................................................................... 368
Chapter 75: Sulfonamides And Trimethoprim .................................................................................................................. 376
Chapter 76: Drug Therapy Of Urinary Tract Infections..................................................................................................... 382
Chapter 77: Antimycobacterial Agents ............................................................................................................................. 389
Chapter 78: Miscellaneous Antibacterial Drugs................................................................................................................ 396
Chapter 79: Antifungal Agents.......................................................................................................................................... 400
Chapter 80: Antiviral Agents I: Drugs For Non-HIV Viral Infections ............................................................................. 410
Chapter 81: Antiviral Agents II: Drugs For HIV Infection And Related Opportunistic Infections ................................... 416
Chapter 82: Drug Therapy Of Sexually Transmitted Diseases .......................................................................................... 421
Chapter 83: Anthelmintics, Antiprotozoal Drugs, And Ectoparasiticides......................................................................... 425
UNIT XIX: CANCER THERAPY ................................................................................................................................. 430
Chapter 84 Introduction To Immunomodulators ............................................................................................................... 430
Chapter 85: Supportive Care Of Patients Receiving Anticancer Drugs ............................................................................ 441
Chapter 86: Drugs For Cancer Pain .................................................................................................................................. 449
UNIT XX: Drugs for Eyes, Ears, and Skin ................................................................................................................ 456
Chapter 87: Drugs For The Eye ........................................................................................................................................ 456
Chapter 88: Drugs For The Skin ....................................................................................................................................... 461
Chapter 89: Drugs For The Ear ......................................................................................................................................... 473
Chapter 90: Agents Affecting The Volume And Ion Content Of Body Fluids ................................................................. 479
Chapter 91: Management Of ST-Elevation Myocardial Infarction ................................................................................... 488
Chapter 92: Additional Acute Care Drugs ........................................................................................................................ 495
