1
BSN 315
BSN 315 - ELIMINATION/GI EXAM QUESTIONS
WITH CORRECT VERIFIED SOLUTIONS 100%
GUARANTEED PASS (LATEST UPDATE)
1. In which time frame would a nurse expect omeprazole to reach
its peak concentration?
0.5 hour
1 hour
2 hours
4 hours: 2 hours
Omeprazole reaches its peak concentration in 2 hours.
2. Which statement regarding the pharmacokinetic profile of
esomeprazole is inaccurate?
"Esomeprazole is well absorbed after oral administration."
"The drug is less than 50% protein bound."
"Esomeprazole is extensively metabolized in the liver."
BSN 315
, 2
BSN 315
"The drug undergoes excretion in the urine.": "The drug is less
than 50% protein bound."
This statement is inaccurate. Esomeprazole is highly protein bound
(97%, not 50%).
Rationale for Incorrect:
esomeprazole is well absorbed when it is orally administered.
esomeprazole undergoes extensive hepatic metabolism.
esomeprazole is excreted in the urine.
3. Which statements are true about the pharmacokinetics of
omeprazole and esomeprazole?
Select all that apply.
Omeprazole is more protein bound than esomeprazole.
Esomeprazole is metabolized more slowly than omeprazole.
Esomeprazole is excreted in the urine, while omeprazole is
excreted in the feces.
Esomeprazole is metabolized in the liver, while omeprazole
undergoes biliary metabolism.
BSN 315
, 3
BSN 315
Esomeprazole achieves a higher blood level and has longer-
lasting effects compared with omeprazole.: Esomeprazole is
metabolized more slowly than omeprazole.
This statement is accurate because esomeprazole undergoes slower
metabolism than omeprazole.
Esomeprazole achieves a higher blood level and has longer-lasting
effects compared with omeprazole.
Because esomeprazole undergoes slower metabolism, it achieves a
higher blood level and has longer-lasting effects compared with
omeprazole.
Rationale for Incorrect:
The protein binding for these two drugs is almost the same; however,
esomeprazole has a slightly higher percentage that is bound to
proteins (97%) compared to omeprazole (95%).
Both esomeprazole and omeprazole are excreted in the urine.
Both esomeprazole and omeprazole are metabolized in the liver.
BSN 315
, 4
BSN 315
4. Which dosage and administration protocol would a nurse
follow with the administration of intravenous esomeprazole to
Ms. Contreras?
Case Study
Ms. Contreras, a 68 yo F, admitted to the hospital with a Dx
gastric ulcer following complaints of severe abdominal pain,
nausea, and anorexia. She developed heart failure a year ago and
has a history of osteoporosis for the past 10 years. Her current
medications are ibuprofen 400 mg three times daily, digoxin 0.125
mg daily, and esomeprazole 20 mg daily. Ms. Contreras's
condition is stable. Current assessment findings are as follows:
abdominal discomfort, palpitations, mild tremors and muscle
spasms, and headache.
If given as an injection, it will be given over 1 minute.
It may be given with other intravenous medications.
If given as an infusion, it will be administered over 10 to 30
minutes.
BSN 315
BSN 315
BSN 315 - ELIMINATION/GI EXAM QUESTIONS
WITH CORRECT VERIFIED SOLUTIONS 100%
GUARANTEED PASS (LATEST UPDATE)
1. In which time frame would a nurse expect omeprazole to reach
its peak concentration?
0.5 hour
1 hour
2 hours
4 hours: 2 hours
Omeprazole reaches its peak concentration in 2 hours.
2. Which statement regarding the pharmacokinetic profile of
esomeprazole is inaccurate?
"Esomeprazole is well absorbed after oral administration."
"The drug is less than 50% protein bound."
"Esomeprazole is extensively metabolized in the liver."
BSN 315
, 2
BSN 315
"The drug undergoes excretion in the urine.": "The drug is less
than 50% protein bound."
This statement is inaccurate. Esomeprazole is highly protein bound
(97%, not 50%).
Rationale for Incorrect:
esomeprazole is well absorbed when it is orally administered.
esomeprazole undergoes extensive hepatic metabolism.
esomeprazole is excreted in the urine.
3. Which statements are true about the pharmacokinetics of
omeprazole and esomeprazole?
Select all that apply.
Omeprazole is more protein bound than esomeprazole.
Esomeprazole is metabolized more slowly than omeprazole.
Esomeprazole is excreted in the urine, while omeprazole is
excreted in the feces.
Esomeprazole is metabolized in the liver, while omeprazole
undergoes biliary metabolism.
BSN 315
, 3
BSN 315
Esomeprazole achieves a higher blood level and has longer-
lasting effects compared with omeprazole.: Esomeprazole is
metabolized more slowly than omeprazole.
This statement is accurate because esomeprazole undergoes slower
metabolism than omeprazole.
Esomeprazole achieves a higher blood level and has longer-lasting
effects compared with omeprazole.
Because esomeprazole undergoes slower metabolism, it achieves a
higher blood level and has longer-lasting effects compared with
omeprazole.
Rationale for Incorrect:
The protein binding for these two drugs is almost the same; however,
esomeprazole has a slightly higher percentage that is bound to
proteins (97%) compared to omeprazole (95%).
Both esomeprazole and omeprazole are excreted in the urine.
Both esomeprazole and omeprazole are metabolized in the liver.
BSN 315
, 4
BSN 315
4. Which dosage and administration protocol would a nurse
follow with the administration of intravenous esomeprazole to
Ms. Contreras?
Case Study
Ms. Contreras, a 68 yo F, admitted to the hospital with a Dx
gastric ulcer following complaints of severe abdominal pain,
nausea, and anorexia. She developed heart failure a year ago and
has a history of osteoporosis for the past 10 years. Her current
medications are ibuprofen 400 mg three times daily, digoxin 0.125
mg daily, and esomeprazole 20 mg daily. Ms. Contreras's
condition is stable. Current assessment findings are as follows:
abdominal discomfort, palpitations, mild tremors and muscle
spasms, and headache.
If given as an injection, it will be given over 1 minute.
It may be given with other intravenous medications.
If given as an infusion, it will be administered over 10 to 30
minutes.
BSN 315
