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Final Exam: NR 568/ NR568 (New 2024/ 2025 Update) Advanced Pharmacology for the AGPCNP Complete Guide (Weeks 5-8 Covered) Questions and Verified Answers - 100% Correct- A Grade - Chamberlain

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Final Exam: NR 568/ NR568 (New 2024/ 2025 Update) Advanced Pharmacology for the AGPCNP Complete Guide (Weeks 5-8 Covered) Questions and Verified Answers - 100% Correct- A Grade - Chamberlain Things to know about each of the major antibiotic drug classes: 2. Classification of Antimicrobial Drugs • There are two main classification schemes: 1. Classification by Susceptible Organism Antibacterial Drugs • Narrow Spectrum-Gram+ cocci/bacilli, Gram- aerobes, M. tuberculosis • Broad Spectrum-Gram+ cocci and gram- bacilli Antiviral Drugs • Drugs for HIV infection • Drugs for influenza • Other antiviral drugs-acycolvir Antifungal Drugs-amphotericin B; Azoles 2. Classification by Mechanism of Action • Inhibitors of cell wall synthesis • Drugs that disrupt the cell membrane • Bactericidal inhibitors of protein synthesis • Bacteriostatic inhibitors of protein synthesis • Drugs that interfere with synthesis or integrity of bacterial DNA and RNA• Antimetabolites • Drugs that suppress viral replication 3. List the 10 classes of Antibiotics name examples HINT (acronym): Abx Can Terminate Protein Synthesis For Microbial Cells Like Germs: Ï Aminoglycosides-gentamicin, streptomycin Ï Cephalosporins-Cephalexin (Keflex) Ï Tetracyclines-tetra/doxyclycline Ï Penicillins-PCN G/V, amoxicillin Ï Sulfonamides-trimethoprim/sulfamethoxazole Ï Fluoroquinolones-ciprofloxacin Ï Macrolides-erythromycin, Azithromycin Ï Carbapenems-imipenem, meropenem Ï Lincosamides-Clindamycin Ï Glycopeptides-Vancomycin 4. Other ways to organize classes of Drugs What is Beta Lactams?: • they have a ²-lactam ring in their structure, the penicillins are known as ²-lactam antibiotic 3 NR • The ²-lactam family also includes the cephalosporins, carbapenems, and aztreonam • All of the ²-lactam antibiotics share the same mechanism of action: disruption of the bacterial cell wall • they are bactericidal; bacteria must be actively growing for them to work 5. Other ways to organize classes of Drugs - Bacteriostatic Inhibitors of Protein Synthesis include: 1. Tetracycline 2. Macrolide 3. Clindamycin 6. Other ways to organize classes of Drugs - Bactericidal antibiotics directly kill bacteria and include: aminoglycosides, beta-lactams, fluoroquinolones, metronidazole, most antimycobact erial agents, streptogramin s, vancomycin. 7. Other ways to organize classes of Drugs What are Antimetabolites?: Sulfonamides, Trimethoprim & Nitrofurantoin 8. Broad spectrum vs narrow spectrum: Broad-spectrum - Broad-spectrum penicillins: ampicillin and others - Extended-spectrum penicillins: piperacillin and others - Cephalospo

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