NRNP 6566 WK1-5 Midterm Study Guide Questions
with Definitive Solutions.
Terms in this set (36)
Describe cytochrome p450 Cytochrome p450 system is a series of enzymes used to
system metabolize medications
Inhibitors block metabolic activity from one or more CYP450 enzymes
Inducers increase CYP450 enzyme activity by increasing enzyme
synthesis
Describe effect on low and Albumin is the plasma protein with the greatest capacity for
high albumin levels on active binding drugs. Binding plasma proteins affect drug
drug levels especially for distribution into tissues, because only drug that is not
drugs that are highly protein bound is available to penetrate tissues, bind to receptors,
bound and exert activity. As free drug leaves the blood stream,
more bound drug is released from binding sites.
Low albumin levels malnutrition, chronic illness
toxicity in patients with low albumin levels, example
Highly protein bound drugs
malnutrition or chronic illness. This is because there are
can lead to
fewer than the normal sites for the drug to bind
, Describe the ways the Alternative routes include:
hepatic first pass effectwhich suppository intravenous
is metabolism during first
intramuscular
pass through the liver
inhalational aerosol
transdermal sublingual
These allow drugs to bypass the first-pass effect and be
absorbed directly into systemic circulation
Be able to calculate Male = 140-age times weight in kilograms divided by
creatinine clearance using serum creatinine times 72. Women = CRCL (male) times
Cockgraft Gault equation: 0.85
Describe what determines half life
the frequency of drug plasma concentration
administration
Be familiar with the beers Potentially Inappropriate Medication Use in Older Adults
criteria and how to use it to call attention to medications that are most commonly
problematic and thus should be avoided in older adults
Describe factors that affect low blood state (shock or arrest), contact time with GI tract
absorption too fast (diarrhea = cant absorb), delayed stomach emptying
(large meal = delayed absorption)Drug- to drug or drug to
food interactions
Describe the factors that low albumin levels, body composition, cardiac decompensation
affect distribution (heart failure), age
Describe the factors that genetics, age, organ function
affect metabolism
Describe factors that affect affected by abnormal kidney or liver function, age, drug
excretion interactions
with Definitive Solutions.
Terms in this set (36)
Describe cytochrome p450 Cytochrome p450 system is a series of enzymes used to
system metabolize medications
Inhibitors block metabolic activity from one or more CYP450 enzymes
Inducers increase CYP450 enzyme activity by increasing enzyme
synthesis
Describe effect on low and Albumin is the plasma protein with the greatest capacity for
high albumin levels on active binding drugs. Binding plasma proteins affect drug
drug levels especially for distribution into tissues, because only drug that is not
drugs that are highly protein bound is available to penetrate tissues, bind to receptors,
bound and exert activity. As free drug leaves the blood stream,
more bound drug is released from binding sites.
Low albumin levels malnutrition, chronic illness
toxicity in patients with low albumin levels, example
Highly protein bound drugs
malnutrition or chronic illness. This is because there are
can lead to
fewer than the normal sites for the drug to bind
, Describe the ways the Alternative routes include:
hepatic first pass effectwhich suppository intravenous
is metabolism during first
intramuscular
pass through the liver
inhalational aerosol
transdermal sublingual
These allow drugs to bypass the first-pass effect and be
absorbed directly into systemic circulation
Be able to calculate Male = 140-age times weight in kilograms divided by
creatinine clearance using serum creatinine times 72. Women = CRCL (male) times
Cockgraft Gault equation: 0.85
Describe what determines half life
the frequency of drug plasma concentration
administration
Be familiar with the beers Potentially Inappropriate Medication Use in Older Adults
criteria and how to use it to call attention to medications that are most commonly
problematic and thus should be avoided in older adults
Describe factors that affect low blood state (shock or arrest), contact time with GI tract
absorption too fast (diarrhea = cant absorb), delayed stomach emptying
(large meal = delayed absorption)Drug- to drug or drug to
food interactions
Describe the factors that low albumin levels, body composition, cardiac decompensation
affect distribution (heart failure), age
Describe the factors that genetics, age, organ function
affect metabolism
Describe factors that affect affected by abnormal kidney or liver function, age, drug
excretion interactions
