NBME PATHOLOGY FINAL EXAM 2025/2026
ACTUAL PREP QUESTIONS AND ANSWERS
GRADED A+
A 32-year-oId Rh-negative woman was delivered of her third child. She had not
sought medical care during pregnancy. Upon admission,/ her saline agglutinin titer
for Rh+ cells was 1:4, and indirect antiglobulin (Coombs) test titer was 1:32. The
infant had a hemoglobin of 10 g/dL and became severely jaundiced, as her second
child had been.
The greatest hazard for the infant is
kernicterus associated with an increased concentration of [conjugated or
unconjugated] bilirubin
unconjugated (indirect) bilinibin
A standardized template bleeding time provides rapid assessment of functional
adequacy of
[platelets or thrombin]
platelets
Involvement of endothelial cells is most characteristic of infection with
,(A) chlamydia
(B) herpesvirus (C) pasteurellae (D) rickettsiae (E) toxoplasmas
rickettsiae
Severe cell injury due to ischemia is characterized by [increased or decreased]
intracellular pH
decreased intracellular pH
Coagulation necrosis is most often h result of local [hyperemia or hypoxia] caused
by loss of blood supply
local hypoxia caused by loss of blood supply
Which of the following pigments will accumulate as the result of peroxidation of
cell membranes?
[Bilirubin or Lipochrome]
Lipochrome
,Cellular regeneration and restoration of normal morphology is possible in each of
the following conditions EXCEPT
(A) diphtheritic myocarditis
(B) damage to preoximal convoluted renal
tubules by mercuric salts
(C) acute erosion of gastric mucosa
(D) viral hepatitis A
(E) squamous metaplasia of the bronchial epi
thelium
diphtheritic myocarditis
Severe cell injury caused by ischemia is characterized by [increased or decreased]
intracellular pH
decreased intracellular pH
Histologic grading systems to classify prostatic carcinoma were evaluated by
investigators on two separate occasions. Results were compared between the
investigators as well as across occasions for each investigator; The purpose of the
multiple measurements was to establish the [accuracy or reliability or validity] of
the grading systems
establish the reliability of the grading systems
, The pathogenesis of granulomatous reactions includes each of the following
EXCEPT
(A) activated macrophages
(B) antibodies
(C) bacterial lipids
(D) insoluble materials
(E) T lymphocytes
antibodies
Development of tensile strength in a heal parallels the appearance of [collagen or
fibroblasts]
collagen
The gross and microscopic characteristics used to differentiate benign from
malignant neoplasms have been proved by testing them for correlation with
[analyses of chromosome number and con figuration or behavior of neoplasms in
human subjects]
behavior of neoplasms in human subjects
ACTUAL PREP QUESTIONS AND ANSWERS
GRADED A+
A 32-year-oId Rh-negative woman was delivered of her third child. She had not
sought medical care during pregnancy. Upon admission,/ her saline agglutinin titer
for Rh+ cells was 1:4, and indirect antiglobulin (Coombs) test titer was 1:32. The
infant had a hemoglobin of 10 g/dL and became severely jaundiced, as her second
child had been.
The greatest hazard for the infant is
kernicterus associated with an increased concentration of [conjugated or
unconjugated] bilirubin
unconjugated (indirect) bilinibin
A standardized template bleeding time provides rapid assessment of functional
adequacy of
[platelets or thrombin]
platelets
Involvement of endothelial cells is most characteristic of infection with
,(A) chlamydia
(B) herpesvirus (C) pasteurellae (D) rickettsiae (E) toxoplasmas
rickettsiae
Severe cell injury due to ischemia is characterized by [increased or decreased]
intracellular pH
decreased intracellular pH
Coagulation necrosis is most often h result of local [hyperemia or hypoxia] caused
by loss of blood supply
local hypoxia caused by loss of blood supply
Which of the following pigments will accumulate as the result of peroxidation of
cell membranes?
[Bilirubin or Lipochrome]
Lipochrome
,Cellular regeneration and restoration of normal morphology is possible in each of
the following conditions EXCEPT
(A) diphtheritic myocarditis
(B) damage to preoximal convoluted renal
tubules by mercuric salts
(C) acute erosion of gastric mucosa
(D) viral hepatitis A
(E) squamous metaplasia of the bronchial epi
thelium
diphtheritic myocarditis
Severe cell injury caused by ischemia is characterized by [increased or decreased]
intracellular pH
decreased intracellular pH
Histologic grading systems to classify prostatic carcinoma were evaluated by
investigators on two separate occasions. Results were compared between the
investigators as well as across occasions for each investigator; The purpose of the
multiple measurements was to establish the [accuracy or reliability or validity] of
the grading systems
establish the reliability of the grading systems
, The pathogenesis of granulomatous reactions includes each of the following
EXCEPT
(A) activated macrophages
(B) antibodies
(C) bacterial lipids
(D) insoluble materials
(E) T lymphocytes
antibodies
Development of tensile strength in a heal parallels the appearance of [collagen or
fibroblasts]
collagen
The gross and microscopic characteristics used to differentiate benign from
malignant neoplasms have been proved by testing them for correlation with
[analyses of chromosome number and con figuration or behavior of neoplasms in
human subjects]
behavior of neoplasms in human subjects
