,Table of Content
T T
ChapterT01:TCellularTBiology ....................................................................................................................................... 4
ChapterT02:TGenesTandTGeneticTDiseases .................................................................................................................. 13
ChapterT03:TEpigeneticsTandTDisease ......................................................................................................................... 23
UTSNTT O .................................................................................................................................................................... 23
ChapterT04:TAlteredTCellularTandTTissueTBiology...................................................................................................... 27
HuetherT&TMcCance:TUnderstandingTPathophysiology,T6thTEdition ......................................................................... 39
ChapterT06:TInnateTImmunity:TInflammationTandTWoundTHealingTHuetherT&TMcCance:TUnderstandingTPathophysi
ology,T6thTEdition ...................................................................................................................................................... 48
ChapterT07:TAdaptiveTImmunity ................................................................................................................................ 60
ChapterT08:TInfectionTandTDefectsTinTMechanismsTofTDefenseTHuetherT&TMcCance:TUnderstandingTPathophysiolo
gy,T6thTEdition ........................................................................................................................................................... 66
SINGTB.COM ............................................................................................................................................................... 74
ChapterT09:TStressTandTDisease.................................................................................................................................. 76
ChapterT10:TBiology,TClinicalTManifestations,TandTTreatmentTofTCancerTHuetherT&TMcCance:TUnderstandingTPath
ophysiology,T6thTEdition ............................................................................................................................................ 81
ChapterT11:TCancerTEpidemiology ............................................................................................................................. 87
ChapterT12:TCancerTinTChildren ................................................................................................................................. 91
ChapterT13:TStructureTandTFunctionTofTtheNeurologicTSystemTHuetherT&TMcCance:TUnderstandingTPathophysiolog
y,T6thTEdition ............................................................................................................................................................. 94
ChapterT14:TPain,TTemperature,TSleep,TandTSensoryTFunctionTHuetherT&TMcCance:TUnderstandingTPathophysiolog
y,T6thTEdition ........................................................................................................................................................... 105
ChapterT15:TAlterationsTinTCognitiveTSystems,TCerebralTHemodynamics,TandTMotorTFunction ............................. 116
ChapterT16:TDisordersTofTtheCentralTandTPeripheralTNervousTSystemsTandTtheNeuromuscularTJunction ............... 126
ChapterT17:TAlterationsTofTNeurologicTFunctionTinTChildrenTHuetherT&TMcCance:TUnderstandingTPathophysiology
,T6thTEdition ............................................................................................................................................................. 138
ChapterT18:TMechanismsTofTHormonalTRegulation ................................................................................................. 147
ChapterT19:TAlterationsTofTHormonalTRegulation .................................................................................................... 156
ChapterT20:TStructureTandTFunctionTofTtheTHematologicTSystemTHuetherT&TMcCance:TUnderstandingTPathophysiol
ogy,T6thTEdition ....................................................................................................................................................... 169
ChapterT21:TAlterationsTofTHematologicTFunction................................................................................................... 176
INGTB.COM ............................................................................................................................................................... 177
ChapterT22:TAlterationsTofTHematologicTFunctionTinTChildrenTHuetherT&TMcCance:TUnderstandingTPathophysiolo
gy,T6thTEdition ......................................................................................................................................................... 192
ChapterT23:TStructureTandTFunctionTofTtheTCardiovascularTandTLymphaticTSystemsTHuetherT&TMcCance:TUndersta
ndingTPathophysiology,T6thTEdition......................................................................................................................... 200
ChapterT24:TAlterationsTofTCardiovascularTFunction ............................................................................................... 210
UTSNTT O .................................................................................................................................................................. 210
SINGTB.COM ............................................................................................................................................................. 223
UTSNTT O .................................................................................................................................................................. 226
UTSNTT O .................................................................................................................................................................. 228
ChapterT25:TAlterationsTofTCardiovascularTFunctionTinTChildrenTHuetherT&TMcCance:TUnderstandingTPathophysiol
ogy,T6thTEdition ....................................................................................................................................................... 229
STNTTT T O ...................................................................................................................................................................... 232
ChapterT26:TStructureTandTFunctionTofTtheTPulmonaryTSystemTHuetherT&TMcCance:TUnderstandingTPathophysiolo
gy,T6thTEdition ......................................................................................................................................................... 236
ChapterT27:TAlterationsTofTPulmonaryTFunction ...................................................................................................... 245
, ChapterT28:TAlterationsTofTPulmonaryTFunctionTinTChildrenTHuetherT&TMcCance:TUnderstandingTPathophysiology
,T6thTEdition ............................................................................................................................................................. 257
ChapterT29:TStructureTandTFunctionTofTtheTRenalTandTUrologicTSystemsTHuetherT&TMcCance:TUnderstandingTPath
ophysiology,T6thTEdition ......................................................................................................................................... 265
ChapterT30:TAlterationsTofTRenalTandTUrinaryTTractTFunctionTHuetherT&TMcCance:TUnderstandingTPathophysiolog
y,T6thTEdition ........................................................................................................................................................... 273
ChapterT31:TAlterationsTofTRenalTandTUrinaryTTractTFunctionTinTChildrenTHuetherT&TMcCance:TUnderstandingTPat
hophysiology,T6thTEdition ....................................................................................................................................... 280
ChapterT32:TStructureTandTFunctionTofTtheTReproductiveTSystemsTHuetherT&TMcCance:TUnderstandingTPathophysi
ology,T6thTEdition .................................................................................................................................................... 286
ChapterT33:TAlterationsTofTtheTFemaleTReproductiveTSystemTHuetherT&TMcCance:TUnderstandingTPathophysiology
,T6thTEdition ............................................................................................................................................................. 295
ChapterT34:TAlterationsTofTtheTMaleTReproductiveTSystem ..................................................................................... 300
ChapterT35:TStructureTandTFunctionTofTtheTDigestiveTSystemTHuetherT&TMcCance:TUnderstandingTPathophysiology
,T6thTEdition ............................................................................................................................................................. 305
ChapterT36:TAlterationsTofTDigestiveTFunction ........................................................................................................ 312
ChapterT37:TAlterationsTofTDigestiveTFunctionTinTChildren ..................................................................................... 325
ChapterT38:TStructureTandTFunctionTofTtheTMusculoskeletalTSystemTHuetherT&TMcCance:TUnderstandingTPathophy
siology,T6thTEdition .................................................................................................................................................. 334
UTSNTT O .................................................................................................................................................................. 337
ChapterT39:TAlterationsTofTMusculoskeletalTFunction ............................................................................................. 342
ChapterT40:TAlterationsTofTMusculoskeletalTFunctionTinTChildrenTHuetherT&TMcCance:TUnderstandingTPathophysi
ology,T6thTEdition .................................................................................................................................................... 352
UTSNTT O .................................................................................................................................................................. 354
ChapterT41:TStructure,TFunction,TandTDisordersTofTtheTIntegumentTHuetherT&TMcCance:TUnderstandingTPathophysi
ology,T6thTEdition .................................................................................................................................................... 357
ChapterT42:TAlterationsTofTtheTIntegumentTinTChildren ........................................................................................... 366
, Chapter 01: Cellular Biology
T T T
Huether & McCance: Understanding Pathophysiology, 6th Edition
T T T T T T
MULTIPLETCHOICE
1. ATstudentTisTobservingTaTcellTunderTtheTmicroscope.TItTisTobservedTtoThaveTsupercoiledTDNA
TwithThistones.TWhichTofTtheTfollowingTwouldTalsoTbeTobservedTbyTtheTstudent?
a. ATsingleTcircularTchromosome
b. ATnucleus
c. Free-floatingTnuclearTmaterial
d. NoTorganelles
ANS:T B
TheTcellTdescribedTisTaTeukaryoticTcell,TsoTitThasThistonesTandTaTsupercoiledTDNATwithinTitsTnu
cleus;Tthus,TtheTnucleusTshouldTbeTobserved.TATsingleTcircularTchromosomeTcalledTaTprokaryot
eTcontainsTfree-floatingTnuclearTmaterialTbutThasTnoTorganelles.
REF:Tp.T2
2. ATnurseTisTinstructingTtheTstaffTaboutTcellularTfunctions.TWhichTcellularTfunctionTisTtheTnurseT
describingTwhenTanTisolatedTcellTabsorbsToxygenTandTusesTitTtoTtransformTnutrientsTtoTenergy?
a. MetabolicTabsorption
b. Communication
c. Secretion
d. Respiration
ANS:TD
TheTcell’sTabilityTtoTabsorbToxygenTisTreferredTtoTasTrespirationTwhileTitsTcommunicationTabilityTinvo
lvesTmaintenanceTofTaTsteadyTdynamicTstate,TmetabolicTabsorptionTprovidesTnutrition,TandTsecretionT
allowsTforTtheTsynthesizingTofTnewTsubstances.
REF:Tp.T2
3. ATeukaryoticTcellTisTundergoingTDNATreplication.TInTwhichTregionTofTtheTcellTwouldTmostTof
T theTgeneticTinformationTbeTcontained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. NucleusTCytoplasm
ANS:TC
TheTregionTofTtheTcellTthatTcontainsTgeneticTmaterial,TincludingTaTlargeTamountTofTribonucleicTa
cid,TmostTofTtheTDNA,TandTDNA-
bindingTproteins,TisTtheTnucleolus,TwhichTisTlocatedTwithinTtheTcell’sTnucleus.TMitochondriaTisT
associatedTwithTcellularTrespiration,TwhileTribosomesTareTinvolvedTwithTproteinTmanufacturing
.TCytoplasmTisTaTfluidTfillingTthatTisTaTcomponentTofTtheTcell.
REF:Tp.T2
T T
ChapterT01:TCellularTBiology ....................................................................................................................................... 4
ChapterT02:TGenesTandTGeneticTDiseases .................................................................................................................. 13
ChapterT03:TEpigeneticsTandTDisease ......................................................................................................................... 23
UTSNTT O .................................................................................................................................................................... 23
ChapterT04:TAlteredTCellularTandTTissueTBiology...................................................................................................... 27
HuetherT&TMcCance:TUnderstandingTPathophysiology,T6thTEdition ......................................................................... 39
ChapterT06:TInnateTImmunity:TInflammationTandTWoundTHealingTHuetherT&TMcCance:TUnderstandingTPathophysi
ology,T6thTEdition ...................................................................................................................................................... 48
ChapterT07:TAdaptiveTImmunity ................................................................................................................................ 60
ChapterT08:TInfectionTandTDefectsTinTMechanismsTofTDefenseTHuetherT&TMcCance:TUnderstandingTPathophysiolo
gy,T6thTEdition ........................................................................................................................................................... 66
SINGTB.COM ............................................................................................................................................................... 74
ChapterT09:TStressTandTDisease.................................................................................................................................. 76
ChapterT10:TBiology,TClinicalTManifestations,TandTTreatmentTofTCancerTHuetherT&TMcCance:TUnderstandingTPath
ophysiology,T6thTEdition ............................................................................................................................................ 81
ChapterT11:TCancerTEpidemiology ............................................................................................................................. 87
ChapterT12:TCancerTinTChildren ................................................................................................................................. 91
ChapterT13:TStructureTandTFunctionTofTtheNeurologicTSystemTHuetherT&TMcCance:TUnderstandingTPathophysiolog
y,T6thTEdition ............................................................................................................................................................. 94
ChapterT14:TPain,TTemperature,TSleep,TandTSensoryTFunctionTHuetherT&TMcCance:TUnderstandingTPathophysiolog
y,T6thTEdition ........................................................................................................................................................... 105
ChapterT15:TAlterationsTinTCognitiveTSystems,TCerebralTHemodynamics,TandTMotorTFunction ............................. 116
ChapterT16:TDisordersTofTtheCentralTandTPeripheralTNervousTSystemsTandTtheNeuromuscularTJunction ............... 126
ChapterT17:TAlterationsTofTNeurologicTFunctionTinTChildrenTHuetherT&TMcCance:TUnderstandingTPathophysiology
,T6thTEdition ............................................................................................................................................................. 138
ChapterT18:TMechanismsTofTHormonalTRegulation ................................................................................................. 147
ChapterT19:TAlterationsTofTHormonalTRegulation .................................................................................................... 156
ChapterT20:TStructureTandTFunctionTofTtheTHematologicTSystemTHuetherT&TMcCance:TUnderstandingTPathophysiol
ogy,T6thTEdition ....................................................................................................................................................... 169
ChapterT21:TAlterationsTofTHematologicTFunction................................................................................................... 176
INGTB.COM ............................................................................................................................................................... 177
ChapterT22:TAlterationsTofTHematologicTFunctionTinTChildrenTHuetherT&TMcCance:TUnderstandingTPathophysiolo
gy,T6thTEdition ......................................................................................................................................................... 192
ChapterT23:TStructureTandTFunctionTofTtheTCardiovascularTandTLymphaticTSystemsTHuetherT&TMcCance:TUndersta
ndingTPathophysiology,T6thTEdition......................................................................................................................... 200
ChapterT24:TAlterationsTofTCardiovascularTFunction ............................................................................................... 210
UTSNTT O .................................................................................................................................................................. 210
SINGTB.COM ............................................................................................................................................................. 223
UTSNTT O .................................................................................................................................................................. 226
UTSNTT O .................................................................................................................................................................. 228
ChapterT25:TAlterationsTofTCardiovascularTFunctionTinTChildrenTHuetherT&TMcCance:TUnderstandingTPathophysiol
ogy,T6thTEdition ....................................................................................................................................................... 229
STNTTT T O ...................................................................................................................................................................... 232
ChapterT26:TStructureTandTFunctionTofTtheTPulmonaryTSystemTHuetherT&TMcCance:TUnderstandingTPathophysiolo
gy,T6thTEdition ......................................................................................................................................................... 236
ChapterT27:TAlterationsTofTPulmonaryTFunction ...................................................................................................... 245
, ChapterT28:TAlterationsTofTPulmonaryTFunctionTinTChildrenTHuetherT&TMcCance:TUnderstandingTPathophysiology
,T6thTEdition ............................................................................................................................................................. 257
ChapterT29:TStructureTandTFunctionTofTtheTRenalTandTUrologicTSystemsTHuetherT&TMcCance:TUnderstandingTPath
ophysiology,T6thTEdition ......................................................................................................................................... 265
ChapterT30:TAlterationsTofTRenalTandTUrinaryTTractTFunctionTHuetherT&TMcCance:TUnderstandingTPathophysiolog
y,T6thTEdition ........................................................................................................................................................... 273
ChapterT31:TAlterationsTofTRenalTandTUrinaryTTractTFunctionTinTChildrenTHuetherT&TMcCance:TUnderstandingTPat
hophysiology,T6thTEdition ....................................................................................................................................... 280
ChapterT32:TStructureTandTFunctionTofTtheTReproductiveTSystemsTHuetherT&TMcCance:TUnderstandingTPathophysi
ology,T6thTEdition .................................................................................................................................................... 286
ChapterT33:TAlterationsTofTtheTFemaleTReproductiveTSystemTHuetherT&TMcCance:TUnderstandingTPathophysiology
,T6thTEdition ............................................................................................................................................................. 295
ChapterT34:TAlterationsTofTtheTMaleTReproductiveTSystem ..................................................................................... 300
ChapterT35:TStructureTandTFunctionTofTtheTDigestiveTSystemTHuetherT&TMcCance:TUnderstandingTPathophysiology
,T6thTEdition ............................................................................................................................................................. 305
ChapterT36:TAlterationsTofTDigestiveTFunction ........................................................................................................ 312
ChapterT37:TAlterationsTofTDigestiveTFunctionTinTChildren ..................................................................................... 325
ChapterT38:TStructureTandTFunctionTofTtheTMusculoskeletalTSystemTHuetherT&TMcCance:TUnderstandingTPathophy
siology,T6thTEdition .................................................................................................................................................. 334
UTSNTT O .................................................................................................................................................................. 337
ChapterT39:TAlterationsTofTMusculoskeletalTFunction ............................................................................................. 342
ChapterT40:TAlterationsTofTMusculoskeletalTFunctionTinTChildrenTHuetherT&TMcCance:TUnderstandingTPathophysi
ology,T6thTEdition .................................................................................................................................................... 352
UTSNTT O .................................................................................................................................................................. 354
ChapterT41:TStructure,TFunction,TandTDisordersTofTtheTIntegumentTHuetherT&TMcCance:TUnderstandingTPathophysi
ology,T6thTEdition .................................................................................................................................................... 357
ChapterT42:TAlterationsTofTtheTIntegumentTinTChildren ........................................................................................... 366
, Chapter 01: Cellular Biology
T T T
Huether & McCance: Understanding Pathophysiology, 6th Edition
T T T T T T
MULTIPLETCHOICE
1. ATstudentTisTobservingTaTcellTunderTtheTmicroscope.TItTisTobservedTtoThaveTsupercoiledTDNA
TwithThistones.TWhichTofTtheTfollowingTwouldTalsoTbeTobservedTbyTtheTstudent?
a. ATsingleTcircularTchromosome
b. ATnucleus
c. Free-floatingTnuclearTmaterial
d. NoTorganelles
ANS:T B
TheTcellTdescribedTisTaTeukaryoticTcell,TsoTitThasThistonesTandTaTsupercoiledTDNATwithinTitsTnu
cleus;Tthus,TtheTnucleusTshouldTbeTobserved.TATsingleTcircularTchromosomeTcalledTaTprokaryot
eTcontainsTfree-floatingTnuclearTmaterialTbutThasTnoTorganelles.
REF:Tp.T2
2. ATnurseTisTinstructingTtheTstaffTaboutTcellularTfunctions.TWhichTcellularTfunctionTisTtheTnurseT
describingTwhenTanTisolatedTcellTabsorbsToxygenTandTusesTitTtoTtransformTnutrientsTtoTenergy?
a. MetabolicTabsorption
b. Communication
c. Secretion
d. Respiration
ANS:TD
TheTcell’sTabilityTtoTabsorbToxygenTisTreferredTtoTasTrespirationTwhileTitsTcommunicationTabilityTinvo
lvesTmaintenanceTofTaTsteadyTdynamicTstate,TmetabolicTabsorptionTprovidesTnutrition,TandTsecretionT
allowsTforTtheTsynthesizingTofTnewTsubstances.
REF:Tp.T2
3. ATeukaryoticTcellTisTundergoingTDNATreplication.TInTwhichTregionTofTtheTcellTwouldTmostTof
T theTgeneticTinformationTbeTcontained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. NucleusTCytoplasm
ANS:TC
TheTregionTofTtheTcellTthatTcontainsTgeneticTmaterial,TincludingTaTlargeTamountTofTribonucleicTa
cid,TmostTofTtheTDNA,TandTDNA-
bindingTproteins,TisTtheTnucleolus,TwhichTisTlocatedTwithinTtheTcell’sTnucleus.TMitochondriaTisT
associatedTwithTcellularTrespiration,TwhileTribosomesTareTinvolvedTwithTproteinTmanufacturing
.TCytoplasmTisTaTfluidTfillingTthatTisTaTcomponentTofTtheTcell.
REF:Tp.T2