D027 NURS 5204 Advanced
Pathopharmacological Foundations(NI)
Objective Assessment Review (Qns & Ans)
2025
1. Which pharmacokinetic parameter is most affected in patients
with chronic liver disease?
a. Absorption
b. Metabolism ( Correct ANS )
c. Distribution
d. Excretion
Rationale: The liver is the primary site of drug metabolism,
and liver impairment significantly affects drug clearance.
2. Which neurotransmitter is most associated with the
pathophysiology of Parkinson's disease?
©2025
, a. Dopamine ( Correct ANS )
b. Acetylcholine
c. Glutamate
d. Serotonin
Rationale: A deficit in dopamine due to degeneration of
dopaminergic neurons leads to the symptoms of Parkinson’s
disease.
3. What is the mechanism of action of angiotensin-converting
enzyme (ACE) inhibitors?
a. Blocking beta-adrenergic receptors
b. Inhibiting the conversion of angiotensin I to angiotensin II (
Correct ANS )
c. Stimulating renin release
d. Promoting sodium retention
Rationale: ACE inhibitors prevent angiotensin II formation,
leading to vasodilation and reduced blood pressure.
4. Which adverse effect is most commonly associated with non-
selective beta blockers?
a. Bradycardia ( Correct ANS )
b. Tachycardia
©2025
, c. Hypoglycemia
d. Hyperkalemia
Rationale: Non-selective beta blockers reduce heart rate,
often leading to bradycardia.
---
Fill-in-the-Blank Questions
5. The primary mechanism of action of selective serotonin
reuptake inhibitors (SSRIs) is the inhibition of __________
reuptake into presynaptic neurons.
ANS: Serotonin
Rationale: SSRIs increase serotonin availability in synaptic
clefts, improving mood in depressive disorders.
6. The therapeutic goal in managing Type 2 diabetes is to
maintain __________ levels within the normal range.
ANS: Blood glucose
Rationale: Tight glycemic control prevents complications
associated with diabetes.
©2025
Pathopharmacological Foundations(NI)
Objective Assessment Review (Qns & Ans)
2025
1. Which pharmacokinetic parameter is most affected in patients
with chronic liver disease?
a. Absorption
b. Metabolism ( Correct ANS )
c. Distribution
d. Excretion
Rationale: The liver is the primary site of drug metabolism,
and liver impairment significantly affects drug clearance.
2. Which neurotransmitter is most associated with the
pathophysiology of Parkinson's disease?
©2025
, a. Dopamine ( Correct ANS )
b. Acetylcholine
c. Glutamate
d. Serotonin
Rationale: A deficit in dopamine due to degeneration of
dopaminergic neurons leads to the symptoms of Parkinson’s
disease.
3. What is the mechanism of action of angiotensin-converting
enzyme (ACE) inhibitors?
a. Blocking beta-adrenergic receptors
b. Inhibiting the conversion of angiotensin I to angiotensin II (
Correct ANS )
c. Stimulating renin release
d. Promoting sodium retention
Rationale: ACE inhibitors prevent angiotensin II formation,
leading to vasodilation and reduced blood pressure.
4. Which adverse effect is most commonly associated with non-
selective beta blockers?
a. Bradycardia ( Correct ANS )
b. Tachycardia
©2025
, c. Hypoglycemia
d. Hyperkalemia
Rationale: Non-selective beta blockers reduce heart rate,
often leading to bradycardia.
---
Fill-in-the-Blank Questions
5. The primary mechanism of action of selective serotonin
reuptake inhibitors (SSRIs) is the inhibition of __________
reuptake into presynaptic neurons.
ANS: Serotonin
Rationale: SSRIs increase serotonin availability in synaptic
clefts, improving mood in depressive disorders.
6. The therapeutic goal in managing Type 2 diabetes is to
maintain __________ levels within the normal range.
ANS: Blood glucose
Rationale: Tight glycemic control prevents complications
associated with diabetes.
©2025
