PC 707 Final Safety Exam Questions and
Answers|Latest Update
What are ADRs? Adverse drug reactions
What is the APRNs responsibility with ADRs? Report to FDA (MedWatch for meds and
VAERS for vaccines)
Why is grapefruit juice considered a CYP 450 inhibitor? Leads to increased amount of
CYP 450 drugs
If someone has a PCN allergy, what are you more likely to do? Give broad spectrum
antibiotics
What are the risk with broad spectrum antibiotics? VRE, C. Diff, MRSA
If an infant needs 3.6 ml of antibiotic, what would you do? Round up to 4
,When are fluoroquinolones contraindicated? (1) pregnancy (2) children under 18
What trimesters of pregnancy should a patient avoid sulfonamides? 1st and 3rd trimester
What are factors that increase antibiotic resistance? (1) increased immunocompromised
people (2) over prescribing of antibiotics (3) antibacterial handsoaps
Are all rashes from PCN considered allergic? No (can get one from mono)
What has been added to PCN to make the drug less resistant to bacteria? Beta-lactamase
What is the only fluoroquinolone that is safe during breastfeeding? Ciprofloxacin
Can you administer 2 live vaccines together? Yes
If 2 live vaccines are not administered together, what is the recommended wait time? 4
weeks
,What is a vaccine against toxins which require sufficient standing antibody titer boosting?
Toxoid vaccine
What is a vaccine that contains only part of the microorganism? Recombinant vaccine
What is a revaccination with same vaccine to replenish the immune response? booster
Who are live vaccines contraindicated in? (1) pregnancy (2) immunocompromised
What types of vaccines have the ability to cause illness? Live vaccines
What drug does tetracycline inhibit? PCN
What should you teach your patient to do with sulfonamide drugs? Drink 8-10 glasses of
water a day, protect yourself from sunlight
If someone is older than 20 and has chicken pox, would you treat them with acyclovir?
Yes
, When are Tamiflu and Relenza most effective? When given within 48 hours of onset
What drugs are contraindicated with antifungals? Statins
What problems can antifungals cause? Hepatotoxic and prolonged QT
What drug does rifampin (TB drug) interfere with? Oral contraceptives
What vitamin must you give with the TB drug INH? B6
What should you avoid with the TB drug INH? Alcohol
What does INH do to CYP450? inducer
What H2RA has the most interactions and should be used sparingly? Cimetidine
(Tagamet)
Answers|Latest Update
What are ADRs? Adverse drug reactions
What is the APRNs responsibility with ADRs? Report to FDA (MedWatch for meds and
VAERS for vaccines)
Why is grapefruit juice considered a CYP 450 inhibitor? Leads to increased amount of
CYP 450 drugs
If someone has a PCN allergy, what are you more likely to do? Give broad spectrum
antibiotics
What are the risk with broad spectrum antibiotics? VRE, C. Diff, MRSA
If an infant needs 3.6 ml of antibiotic, what would you do? Round up to 4
,When are fluoroquinolones contraindicated? (1) pregnancy (2) children under 18
What trimesters of pregnancy should a patient avoid sulfonamides? 1st and 3rd trimester
What are factors that increase antibiotic resistance? (1) increased immunocompromised
people (2) over prescribing of antibiotics (3) antibacterial handsoaps
Are all rashes from PCN considered allergic? No (can get one from mono)
What has been added to PCN to make the drug less resistant to bacteria? Beta-lactamase
What is the only fluoroquinolone that is safe during breastfeeding? Ciprofloxacin
Can you administer 2 live vaccines together? Yes
If 2 live vaccines are not administered together, what is the recommended wait time? 4
weeks
,What is a vaccine against toxins which require sufficient standing antibody titer boosting?
Toxoid vaccine
What is a vaccine that contains only part of the microorganism? Recombinant vaccine
What is a revaccination with same vaccine to replenish the immune response? booster
Who are live vaccines contraindicated in? (1) pregnancy (2) immunocompromised
What types of vaccines have the ability to cause illness? Live vaccines
What drug does tetracycline inhibit? PCN
What should you teach your patient to do with sulfonamide drugs? Drink 8-10 glasses of
water a day, protect yourself from sunlight
If someone is older than 20 and has chicken pox, would you treat them with acyclovir?
Yes
, When are Tamiflu and Relenza most effective? When given within 48 hours of onset
What drugs are contraindicated with antifungals? Statins
What problems can antifungals cause? Hepatotoxic and prolonged QT
What drug does rifampin (TB drug) interfere with? Oral contraceptives
What vitamin must you give with the TB drug INH? B6
What should you avoid with the TB drug INH? Alcohol
What does INH do to CYP450? inducer
What H2RA has the most interactions and should be used sparingly? Cimetidine
(Tagamet)
