PHCH 667 FINAL QUESTIONS AND
ANSWERS
which of the following is NOT true about kidney glomerulus?
A. protein biological (e.g. monoclonal antibodies) are filtered at glomerulus
B. most small molecule drugs are filtered at glomerulus, except for drugs bound to protein plasma
C. GFR reflects kidney function and disease
D. filter substrates with moelcules weight <40,000 Da ✅✅ANSW-A. protein biological (mAbs) are
filtered at glomerulus
Urea is mainly produced in the liver to remove toxic ammonia. Although urea is almost completely
filtered at glomerulus, approximately 50% of the filtered urea is re-absorbed by kidney tubules
A. True
B. False ✅✅ANSW-A. True
Which of the following is NOT true about the creatinine renal function test?
A. body fat does not affect SCr level
B. increased body muscle mass does not significantly change SCr
C. creatine, precursor of creatinine, is synthesized in the liver and stored in the muscle as creatinine
phosphate. creatinine is produced by cyclist ion of creatinine and then escapes muscle cell
membrane into the blood
D. SCr can be determined using Jaffe reaction, enzymatic assay, or HPLC method ✅✅ANSW-B.
increased body muscle mass does not significantly change SCr
A patient, 11 years old, is prescribed imipenem IV for a gram-negative bacterial infection. imipenem
Overdose can cause seizure and other CNS adverse effects, especially in patients with CNS disorders
and/or compromised renal function. imipenem dosage needs to be adjusted based on calculated
CrCl or GFR. Which formula would be most appropriate in this case to calculate CrCl or GFR?
A. Schwartz formula or Counahan-Baratt formula
B. MDRD formula
C. 24-hour urine collection method
D. CG equation ✅✅ANSW-A. schwartz formula or counahan-baratt formula
, The inulin clearance rate is equal to the GFR, because inulin is completely filtered through the
glomerulus and not metabolized, not secreted, and not re-absorbed at kidney tubules.
A. True
B. False ✅✅ANSW-A. True
Which drug can turn urine into red or orange color?
A. Doxorubicin
B. Amitriptyline
C. Atorvastatin
D. Chloroquine ✅✅ANSW-A. Doxorubicin
Creatinine Clearance is inversely related to the serum creatinine concentration.
A. True
B. False ✅✅ANSW-A. True
***urine creatinine concentration IS proportional to clearance***
Which of the following would elevate serum creatinine concentrations?
A. dehydration
B. renal dysfunction caused by aminoglycosides
C. all are correct
D. Urinary tract obstruction ✅✅ANSW-C. all are correct
drugs that inhibit tubular secretion of creatinine can cause false positive result for CKD, due to an
elevated serum creatinine concentration without any damage to renal function. these drugs
include..
A. cimetidine and probenecid
B. acetaminophen and ibuprofen
C. warfarin and sildenafil
D. fexofenadine and loratidine ✅✅ANSW-A. cimetidine and probenecid
During dipstick urinalysis, normal urine should not contain the following substances except for..
A. glucose
b. protein
ANSWERS
which of the following is NOT true about kidney glomerulus?
A. protein biological (e.g. monoclonal antibodies) are filtered at glomerulus
B. most small molecule drugs are filtered at glomerulus, except for drugs bound to protein plasma
C. GFR reflects kidney function and disease
D. filter substrates with moelcules weight <40,000 Da ✅✅ANSW-A. protein biological (mAbs) are
filtered at glomerulus
Urea is mainly produced in the liver to remove toxic ammonia. Although urea is almost completely
filtered at glomerulus, approximately 50% of the filtered urea is re-absorbed by kidney tubules
A. True
B. False ✅✅ANSW-A. True
Which of the following is NOT true about the creatinine renal function test?
A. body fat does not affect SCr level
B. increased body muscle mass does not significantly change SCr
C. creatine, precursor of creatinine, is synthesized in the liver and stored in the muscle as creatinine
phosphate. creatinine is produced by cyclist ion of creatinine and then escapes muscle cell
membrane into the blood
D. SCr can be determined using Jaffe reaction, enzymatic assay, or HPLC method ✅✅ANSW-B.
increased body muscle mass does not significantly change SCr
A patient, 11 years old, is prescribed imipenem IV for a gram-negative bacterial infection. imipenem
Overdose can cause seizure and other CNS adverse effects, especially in patients with CNS disorders
and/or compromised renal function. imipenem dosage needs to be adjusted based on calculated
CrCl or GFR. Which formula would be most appropriate in this case to calculate CrCl or GFR?
A. Schwartz formula or Counahan-Baratt formula
B. MDRD formula
C. 24-hour urine collection method
D. CG equation ✅✅ANSW-A. schwartz formula or counahan-baratt formula
, The inulin clearance rate is equal to the GFR, because inulin is completely filtered through the
glomerulus and not metabolized, not secreted, and not re-absorbed at kidney tubules.
A. True
B. False ✅✅ANSW-A. True
Which drug can turn urine into red or orange color?
A. Doxorubicin
B. Amitriptyline
C. Atorvastatin
D. Chloroquine ✅✅ANSW-A. Doxorubicin
Creatinine Clearance is inversely related to the serum creatinine concentration.
A. True
B. False ✅✅ANSW-A. True
***urine creatinine concentration IS proportional to clearance***
Which of the following would elevate serum creatinine concentrations?
A. dehydration
B. renal dysfunction caused by aminoglycosides
C. all are correct
D. Urinary tract obstruction ✅✅ANSW-C. all are correct
drugs that inhibit tubular secretion of creatinine can cause false positive result for CKD, due to an
elevated serum creatinine concentration without any damage to renal function. these drugs
include..
A. cimetidine and probenecid
B. acetaminophen and ibuprofen
C. warfarin and sildenafil
D. fexofenadine and loratidine ✅✅ANSW-A. cimetidine and probenecid
During dipstick urinalysis, normal urine should not contain the following substances except for..
A. glucose
b. protein
