BCH 410 Final Exam Questions And Answers

BCH 410 Final Exam t t t


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BCH 410 Final Exam Questions And
Answers
1. An A’T variant in the HBB gene is the causative agent of sickle cell anemia,a disor
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der that primarily affects people of African descent. Sickle cell anemia is named af
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ter the shape of the red blood cells in individuals with this disorder. The mutation
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within the HBB gene results in a dysfunctional hemoglobin protein,which is resp
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onsible for the sickle shape of the red blood cell.Patients diagnosed with this disor
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der often exhibit a variety of symptoms, such as episodes of pain, swelling of han
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ds and feet, delayed growth, and vision problems amongst others.The symptom
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s associated with the gene variant, such as vision problems, are an example of th
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e relationship between genes and traits:
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a. at the population level.
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b. at the organism level.
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c. at the cellular level.
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d. at the molecular level.
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e. at a physiological level.: b.at the organism level
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2. Decreased gene dosage may result from: a. Gene mutation that results in hig t t t t t t t t t t t t


h functioning protein
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b. Gene duplication t


c. Gain of chromosome t t


d. Gene deletion t


e. Unwanted areas of euchromatin: d.Gene deletion t t t t t t


3. What can be concluded based on the following karyotype?:
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4. A sex-specific example of decreasing gene dosing is:
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a. X chromosome inactivation
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b. mitochondrial DNA inheritance: t t


5. Mitochondrial-
linked diseases can be passed down from father to offspring because:
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a. paternal mitochondrial DNA is very often passed down to the offspring t t t t t t t t t t


b. paternal nuclear DNA encodes genes for mitochondrial function.: t t t t t t t


6. Which one of the following proteins does not function during elongation of pro
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karyotic DNA replication? t t


1t/t6

, BCH 410 Final Exam
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a. DNA Polymerase I
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b. DnaB
c. DnaA
d. DnaG
e. DNA polymerase III:
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7. During initiation of DNA replication in E. coli, DnaA-
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ATP saturates the initiator binding element.This filament formation results in t
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orsional stress on the DNA.This torsional stress is relieved when:
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2t/t6