BCH Final Exam Questions And Answers

BCH Final Exam Questions And Answers
______________rinrcomplexr1rofroxphosralllwsrforrH+rtormoveracrossrthermembraner-
rCORRECTrrANSWER-

conformationalrchangesrcausedrbyrthermovingrofrelectronsrthroughrthercomplex

______________rmetabolicrpathwayrisrmostrfrequentlyrusedrforrbuildingrbiopolymersrsuchr
asrlipids,rnucleicracids,rproteinsrandrpolysaccharidesr-rCORRECTrrANSWER-
spiralrpathway

_________________risrboundrtortherinnerrmitochondriarmembranerandrcontributesritsrelec
tronsrvierQH2rtorthercomplexr2rinrtheroxidativerphosphorylationrpathwayrdirectlyr-
rCORRECTrrANSWER-succinaterdehydrogenase




__________________risrequivalentrtorcomplexr2rinroxphosr-rCORRECTrrANSWER-
succinaterdehydrogenase

__________________rmetabolismrisroftenrdefinedrasrthoserreactionsrinvolvingrlowrmolecu
larrweightrbiomoleculesr-rCORRECTrrANSWER-intermediary

__________________rphosphorylatesrpyruvaterdehydrogenaserwhiler_______________
__rdephosphorylatesritr(thisrisrregulationrbyr______________________)r-
rCORRECTrrANSWER-PDHrkinaser

PDHrphosphataser
covalentrmodification

1rNADHr-->r____rATPr-rCORRECTrrANSWER-2.5

1rQH2r--->r____rATPr-rCORRECTrrANSWER-1.5

1,3-
Bisphosphoglyceraterhasrarhighrphosphorylrgroupr____________randrresultsrinrtherproduc
tionrofr________________ritrhasrardeltarGrofr-rCORRECTrrANSWER-transferrpotential
firstrATProfrglycolysisr
-49.4rkJ/mol

arsignificantramountrofrgenomerisrcommittedrtor______________
-r____%rofr_____rinrercoli

,-r_____%rofr_____rinryeast
-______%rofr______rinrhumansr-rCORRECTrrANSWER-metabolismr
21rofr900
21rofr1200
23rofr5000

AcetylrCoArcontainsrarhighrenergyr___________rbondr-rCORRECTrrANSWER-thioester

aconitaserconvertsrar___________ralcoholrtorar__________ralcoholr
explainrwhyr-rCORRECTrrANSWER-tertiaryrtorsecondary
tertiaryrarerchemicallyrveryrstablerandrunreactiverwhilersecondaryrarermorerreactiverwhichri
srnecessaryrforrthernextrreactionrtorberablertoroccur

actualrgibbsrfreerenergyrchange,rnotr________________________-
rdeterminesrtherdirectionrofrmetabolicrreactionsr-rCORRECTrrANSWER-

standardrfreerenergyrchange

ADPrtorAMPrdeltarGr=r-rCORRECTrrANSWER--13.8rkJ/mol

ADPrtorAMPrdeltarG=r-rCORRECTrrANSWER--45.6rkJ/mol

allrthreerofrtherregulatedrenzymesrinrglycolysisrarer__________r-rCORRECTrrANSWER-
kinases

alpharketoglutaratercanrleadrtortherformationrofr______________randr_______________-r-
rCORRECTrrANSWER-glutamater

otherraminoracids,rpurines

Alpharketoglutaraterisrar______________________-r-rCORRECTrrANSWER-
5rcarbonrdicarboxylicracid

alpharketogluteraterdehydrogenasercatalyzesr_____________________rreactionrthatruse
sranr_____________randr_______________rtorproducerarhighrenergyr__________rbondra
ndr__________randr______________r-rCORRECTrrANSWER-oxidation-
reductionrreactionr
alpharketoracidr
coenzymerA
thioester
CO2randrNADH

anrenergeticallyrunfavorablermetabolicrreactionrcanrberdrivenrbyrcouplingr_____________
_______rwithrtherreactionr-rCORRECTrrANSWER-ATPrhydrolysis

anabolicrreactionsrarertypicallyr_______________rreactionsr-rCORRECTrrANSWER-
reduction

, atrstandardrconditionsrtherthermodynamicsrofrarreactionratr_________________r-
rCORRECTrrANSWER-equilibrium




ATPrisrarproductrofr____________rreactionsrandranrenergyrsourcerforr_____________rrea
ctionsr-rCORRECTrrANSWER-catabolicr
anabolic

ATPrisrtheruniversalrcurrencyrofr____________________rinrallrbiologicalrsystemsr-
rCORRECTrrANSWER-freerenergy




ATPrsynthaserisrcomposedrofrbetweenr_____rtor_____rsubunitsrthatrcanrberdividedrintor___
__randr______rcomponentsr-rCORRECTrrANSWER-22randr26
Fnot
F1

ATPrtorADPrdeltarG=r-rCORRECTrrANSWER--32.2rkJ/mol

bothrNADHrandrQH2rcontainr___________________randrwillrberusedrtorproducerenergyras
rATPrduringr__________________r-rCORRECTrrANSWER-reducingrpowerr

oxidativerphosphorylation

catabolicrreactionsrarertypicallyr______________rreactionsr-rCORRECTrrANSWER-
oxidation

citratercanrleadrtortherformationrofr____________r-rCORRECTrrANSWER-
fattyracidsrandrsterols

Citratersynthaserisranrexamplerofrinducedrfitrenzymerregulation.rexplainr-
rCORRECTrrANSWER--

rbindingrofroxaloacetaterinducesrclosurerofrthersmallrdomainrwhichrcreatesrarbindingrsiterforr

acetylrCoA

citratersynthase,risocitraterdehydrogenase,randralpharketogluteraterdehydrogenaserarerallr
controlledrbyr_____________rregulationr-rCORRECTrrANSWER-allosteric

coenzymerQrmovesrfreelyrinrther_______________b/critrisr______________r-
rCORRECTrrANSWER-lipidrbilayerr

lipidrsoluble

coenzymesrcanrberdividedrintor________________randr__________r-
rCORRECTrrANSWER-cosubstratesr(looselyrbound)r

prostheticrgroupsr(tightleyrbound)

Cofactorsrcanrberdividedrintor________________randr_______________r-
rCORRECTrrANSWER-essentialrionsrandrcoenzymes