MLS 2210- Exam 2 (153 questions with verified answers

MLS 2210- Exam 2 (153 questions with
verified answers

Rule of Reciprocity - correct answer ✔ABO blood groups- They have
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antibodies to antigens that they lack.
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ABO biochemisty- - correct answer ✔Mendelian, co-dominant, Chromosome
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9, over 200 alleles identified. O gene is an amorph (silent alleles, O is
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recessive)


ABH antigen formation is dependent upon interaction of genes at three
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separate loci- - correct answer ✔ABO, Hh, and Se
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glycosyltransferases - correct answer ✔add sugars to a basic precursor
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substance


Where are the type 2 precursor chains located? - correct answer ✔On RBC
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membranes


Where are type 1 precursor chains located? - correct answer ✔Secretions
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What is the percent of antigen sites on RBC of Neonates? - correct answer
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✔25-50%


Describe the H antigen - correct answer ✔Ceramide (RBC membrane) ->
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Glucose -> D-Galactose -> N-acetlyglucosamine-> D-Galactose-> Fucose
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,what is the enzyme for the A gene? - correct answer ✔Alpha-3-N-
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acetylgalactosaminyltransferase


Describe the A antigen- - correct answer ✔Ceramide (RBC membrane) ->
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Glucose -> D-Galactose -> N-acetlyglucosamine-> D-Galactose-> Fucose
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+ N-acetylgalactosamine
n




What is the enzyme for the B-gene? - correct answer ✔Alpha-3-D-
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galactosyltransferase


Describe the B antigen- - correct answer ✔Ceramide (RBC membrane) ->
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Glucose -> D-Galactose -> N-acetlyglucosamine-> D-Galactose-> Fucose
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+ D- Galactose
n n




A Terminal sugar? - correct answer ✔GalNAc
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B Terminal sugar? - correct answer ✔Gal
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Individuals who are Group O will inherit what? - correct answer ✔At least
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one H gene (HH or Hh) and two O genes (OO)
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What percentage is the H gene present in? - correct answer ✔More than
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99.99%

, What is the term known as (Oh) or (hh)? - correct answer ✔Bombay
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phenotype, no H antigen has formed, no ABO expression can occur
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When was Bombay phenotype discovered? - correct answer ✔Bhende
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discoved it in 1952 in Bombay, India. 130 cases have been reported
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worldwide.


What do bombay individuals produce? - correct answer ✔Anti-A, Anti-B,
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Anti-A,B, and Anti-H n n




Bombay are type O, but why can't they receive O blood? - correct answer
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✔Transfusion hemolytic reaction with the H antigen that is high. Oh can only
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receive Oh blood.
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Anti-H lectin - correct answer ✔Ulex europeaus
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ABO Gene and Locus? - correct answer ✔ABO and 9q
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H Gene and Locus? - correct answer ✔FUT1 and 19q
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Se Gene and Locus? - correct answer ✔FUT2 and 19q
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What percent inherit H gene and Se gene? - correct answer ✔99.99% and
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80%


Type 1 chains - correct answer ✔Glycoproteins in secretions
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